US4716225A
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Radioopaque sugar derivatives and a method of metabolic mapping using the same
Assignee: Georgetown University
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Filing: 1985-09-30
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Granted: 1987-12-29
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Expires: 2005-09-30
Abstract
Abstract A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which entails injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into the mammalian body, and scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components.
Inventors
- 👤 Robert S. Ledley
- 👤 Douglas M. Gersten
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:08
CPC Classifications
C; C07; C07H; C07H5/00; C07H5/02; A; A61; A61K; A61K49/00; A61K49/04; A61K49/0433; A61K49/0438
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
68 words
A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which comprises: (a) injecting an effective amount of a 2-,5-, or 6-iodo-substituted hexose, as a contrast medium, into said mammalian body, and (b) scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components.
Claim 2
Independent Claim
68 words
A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which comprises: (a) injecting an effective amount of a 2-,5-, or 6-iodo-substituted hexose, as a contrast medium, into said mammalian body, and (b) scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the central nervous system component or components.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein said hexose is a glucose, galactose, mannose or allose.
Claim 4
Dependent Claim
10 words
The method of claim 1, wherein said hexose is 6-iodo-galactose.
Claim 5
Dependent Claim
29 words
The method of claim 1, wherein an amount of said hexose is injected sufficient to obtain an initial blood concentration of at least about 10-2M in said mammalian body.
Claim 6
Dependent Claim
26 words
The method of claim 1, wherein said hexose is injected in the amount of about 0.175 grams to 0.50 grams per kilogram of mammalian body weight.
Claim 7
Dependent Claim
11 words
The method of claim 1, wherein said mammal is a human.
Claim 8
Dependent Claim
22 words
The method of claim 1, wherein said central nervous system components comprise the brain or the spinal cord or a combination thereof.
Claim 9
Dependent Claim
14 words
The method of claim 7, wherein said central nervous system component comprises the brain.
Claim 10
Dependent Claim
18 words
The method of claim 8, wherein said central nervous system component comprises the cortical regions of the brain.
Claim 11
Dependent Claim
26 words
The method of claim 8, wherein said central nervous system component comprises the cortical area of the posterior portion of the frontal lobe of the brain.
Claim 12
Independent Claim
55 words
A method of metabolically mapping a human brain by computerized axial tomography, which comprises: (a) injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into said mammalian body, and (b) scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the brain.
Claim 13
Independent Claim
55 words
A method of metabolically mapping a human brain by computerized axial tomography, which comprises: (a) injecting an effective amount of a 2-, 5- or 6-iodo-substituted hexose, as a contrast medium, into said mammalian body, and (b) scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said hexose in the brain.
Claim 14
Dependent Claim
15 words
The method of claim 11, wherein said hexose is a glucose, galactose, mannose or allose.
Claim 15
Dependent Claim
10 words
The method of claim 11, wherein said hexose is 6-iodo-galactose.
Claim 16
Dependent Claim
31 words
The method of claim 11, wherein an amount of said hexose is injected sufficient to obtain an initial blood concentration of at least about 10 -2 M in said mammalian body.
Claim 17
Dependent Claim
28 words
The method of claim 11, wherein an amount of said hexose is injected sufficient to obtain a brain concentration of about 10 -4 M to 10 -3 M.
Claim 18
Independent Claim
73 words
A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which comprises: (a) injecting an effective amount of a 2-, 5-, or 6-iodo-substituted glucose or galactose, as a contrast medium, into said mammalian body, and (b) scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said glucose or galactose in the central nervous system component or components.
Claim 19
Independent Claim
73 words
A method of metabolically mapping one or more central nervous system components of a mammalian body by computerized axial tomography scanning which comprises: (a) injecting an effective amount of a 2-, 5-, or 6-iodo-substituted glucose or galactose, as a contrast medium, into said mammalian body, and (b) scanning the mammalian body by computerized axial tomography, thereby visualizing the concentration flux of said glucose or galactose in the central nervous system component or components.
Claim 20
Independent Claim
59 words
A method of metabolically mapping a human brain by computerized axial tomography, which comprises: (a) injecting an effective amount of a 2-, 5-, or 6-iodo-substituted glucose or galactose, as a contrast medium, into a human body, and (b) scanning the human brain by computerized axial tomography, thereby visualizing the concentration flux of said glucose or galactose in the brain.
Claim 21
Independent Claim
59 words
A method of metabolically mapping a human brain by computerized axial tomography, which comprises: (a) injecting an effective amount of a 2-, 5-, or 6-iodo-substituted glucose or galactose, as a contrast medium, into a human body, and (b) scanning the human brain by computerized axial tomography, thereby visualizing the concentration flux of said glucose or galactose in the brain.
Claim 22
Dependent Claim
18 words
A 2- or 5-iodo-substituted hexose, wherein said hexose is selected from the group consisting of glucose, and galactose.
Claim 23
Dependent Claim
18 words
A 2- or 5-iodo-substituted hexose, wherein said hexose is selected from the group consisting of glucose, and galactose.
Claim 24
Dependent Claim
23 words
A 2-, 5- or 6-iodo-substituted hexose, wherein said hexose is selected from the group consisting of allose, altrose, mannose, gulose, idose, and talose.
Claim 25
Dependent Claim
23 words
A 2-, 5- or 6-iodo-substituted hexose, wherein said hexose is selected from the group consisting of allose, altrose, mannose, gulose, idose, and talose.
References Cited (Backward Citations)
US2365776A
Cited
US2365777A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-28 | 1991-06-29 | 1991-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-28 | 1995-06-29 | 1995-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-28 | 1999-06-29 | 1999-12-29 | $7700.00 | Window Closed / Lapsed |