US4714759A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunotoxin therapy of allergy
Assignee: IMMUNET A CORP OF
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Filing: 1985-12-02
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Granted: 1987-12-22
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Expires: 2005-12-02
Abstract
Abstract A product and process for treating allergy are described. An immunotoxin specific for the IgE isotype is used to eliminate the IgE producing B-lymphocytes responsible for allergy.
Inventors
- 👤 Robert B. Whitaker, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:30
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6819; A61K47/6825; A61K47/6827; A61K47/6889; Y; Y10; Y10S; Y10S424/00; Y10S424/805; Y10S424/81; Y10S530/00; Y10S530/862; Y10S530/866; Y10S530/868
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
22 words
A method for treating allergy comprising, introducing in vivo an immunotoxin to selectively deplete the population of cells bearing the IgE isotype.
Claim 2
Independent Claim
22 words
A method for treating allergy comprising, introducing in vivo an immunotoxin to selectively deplete the population of cells bearing the IgE isotype.
Claim 3
Dependent Claim
27 words
A method for treating allergy as claimed in claim 1 wherein said immunotoxin is an antibody coupled to a toxin, said antibody having specificity for IgE isotype.
Claim 4
Dependent Claim
16 words
A method for treating allergy as claimed in claim 2 wherein said toxin is A chain.
Claim 5
Dependent Claim
24 words
A method for treating allergy as claimed in claim 3 wherein said A chain is coupled to said antibody via a MBS coupling reaction.
Claim 6
Dependent Claim
17 words
A method for treating allergy as claimed in claim 2 wherein said toxin is pokeweed antiviral protein.
Claim 7
Dependent Claim
25 words
A method for treating allergy as claimed in claim 5 wherein said pokeweed antiviral protein is coupled to said antibody via a SADP coupling reaction.
Claim 8
Dependent Claim
24 words
A method for treating allergy as claimed in claim 2 wherein said toxin is intact ricin having a B chain and an A chain.
Claim 9
Dependent Claim
27 words
A method for treating allergy as claimed in claim 7 wherein said B chain of said ricin is coupled to said antibody via a preiodate-carbohydrate coupling reaction.
Claim 10
Dependent Claim
53 words
A method for treating allergy as claimed in claim 1 wherein said immunotoxin comprises a mixture of a first immunotoxin comprising a first antibody having selective specificity for IgE isotype and coupled to A chain and, a second immunotoxin comprising a second antibody having selective specificity for IgE isotype coupled to B chain.
Claim 11
Dependent Claim
33 words
A method for treating allergy as claimed in claim 1 wherein said immunotoxin is a Fab fragment of an antibody coupled to a toxin, said Fab fragment having selective specificity for IgE isotype.
Claim 12
Dependent Claim
16 words
A method for treating allergy as claimed in claim 10 wherein said toxin is A chain.
Claim 13
Dependent Claim
25 words
A method for treating allergy as claimed in claim 11 wherein said A chain is coupled to said Fab fragment via a MBS coupling reaction.
Claim 14
Dependent Claim
34 words
A method for treating allergy as claimed in claim 1 wherein said immunotoxin is a Fab 2 fragment of antibody coupled to a toxin, said Fab 2 fragment having selective specificity for IgE isotype.
Claim 15
Dependent Claim
19 words
A preparation useful in treating allergy consisting essentially of immunotoxin having activity selective for cells bearing the IgE isotype.
Claim 16
Dependent Claim
19 words
A preparation useful in treating allergy consisting essentially of immunotoxin having activity selective for cells bearing the IgE isotype.
Claim 17
Dependent Claim
25 words
A preparation as claimed in claim 14 wherein said immunotoxin consists essentially of antibody coupled to toxin, said antibody having selective specificity for IgE isotype.
Claim 18
Dependent Claim
31 words
A preparation as claimed in claim 14 wherein said immunotoxin consists essentially of Fab 2 fragment of antibody coupled to toxin, said Fab 2 fragment having selective specificity for IgE isotype.
Claim 19
Dependent Claim
27 words
A preparation as claimed in claim 14 wherein said immunotoxin consists essentially of Fab fragment coupled to toxin, said Fab fragment having selective specificity for IgE isotype.
Claim 20
Dependent Claim
13 words
A preparation as claimed in claim 17 wherein said toxin is A chain.
Claim 21
Dependent Claim
22 words
A preparation as claimed in claim 18 wherein said A chain is coupled to said Fab fragment via a MBS coupling reaction.
Claim 22
Dependent Claim
14 words
A preparation as claimed in claim 15 wherein said antibody is a monoclonal antibody.
Claim 23
Dependent Claim
14 words
A preparation as claimed in claim 17 wherein said toxin is pokeweed antiviral protein.
Claim 24
Dependent Claim
21 words
A preparation as claimed in claim 21 wherein said toxin is bound to said Fab fragment via a SADP coupling reaction.
References Cited (Backward Citations)
US4564600A
Cited
US4661347A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-21 | 1991-06-22 | 1991-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-21 | 1995-06-22 | 1995-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-21 | 1999-06-22 | 1999-12-22 | $7700.00 | Window Closed / Lapsed |