US4713370A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Carnitine and its use in reducing cardiac toxicity and as a synergist with cytostats
Assignee: Individual
•
Filing: 1982-04-22
•
Granted: 1987-12-15
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Expires: 2002-04-22
Abstract
Abstract Carnitine may be administered for the purpose of reducing cardiac toxicity resulting from administration of a cytostat. Carnitine may also be administered in combination with cytostats to produce synergistic cytostatic activity.
Inventors
- 👤 Stephen L. De Felice
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/205
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A method of effecting cytoxicity in humans and animals which comprises administering to a human or animal in need thereof, a therapeutically effective amount of a cytostat selected from the group consisting of daunomycin, N-acetyl-daunomycin and daunomycin oxine and a synergistically effective amount of βhydroxy-γ-trimethylaminobutyric acid, an isomer thereof, a pharmaceutically acceptible salt thereof or a pharmaceutically acceptable salt of an isomer thereof.
Claim 2
Independent Claim
63 words
A method of effecting cytoxicity in humans and animals which comprises administering to a human or animal in need thereof, a therapeutically effective amount of a cytostat selected from the group consisting of daunomycin, N-acetyl-daunomycin and daunomycin oxine and a synergistically effective amount of βhydroxy-γ-trimethylaminobutyric acid, an isomer thereof, a pharmaceutically acceptible salt thereof or a pharmaceutically acceptable salt of an isomer thereof.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein the administration is substantially simultaneous.
Claim 4
Dependent Claim
11 words
A method according to claim 1 wherein the administration is sequential.
Claim 5
Dependent Claim
16 words
A method according to claim 1 wherein the β-hydroxy-γ-trimethylaminobutyric acid is administered as the hydrochloride salt.
Claim 6
Dependent Claim
11 words
A method according to claim 1 wherein the cytostat is daunomycin.
Claim 7
Dependent Claim
11 words
A method according to claim 1 wherein the cytostat is N-acetyl-daunomycin.
Claim 8
Dependent Claim
12 words
A method according to claim 1 wherein the cytostat is daunomycin oxime.
Claim 9
Dependent Claim
43 words
A method according to claim 1 wherein the cytostat is administered followed one (1) hour later by administration of the synergistically effective amount of β-hydroxy-γ-trimethylaminobutyric acid, an isomer thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable salt of an isomer thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-12-14 | 1991-06-15 | 1991-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-12-14 | 1995-06-15 | 1995-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-12-14 | 1999-06-15 | 1999-12-15 | $7700.00 | Window Closed / Lapsed |