US4708958A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents
Assignee: GD Searle LLC
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Filing: 1986-09-24
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Granted: 1987-11-24
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Expires: 2006-09-24
Abstract
Abstract This invention relates to novel 6-(imidazolylphenyl)-4-iminopyrimidinone compounds having antihypertensive and platelet aggregation inhibition activity. More particularly, the present invention relates to a novel class of pyrimidinone derivatives represented by the formula ##STR1## and the pharmaceutically acceptable salts thereof wherein X may be one to three substituents selected from the group consisting of R,--OR,--SR,--NHR,--NR 2 , Cl, Br, F, NO 2 ,--COCH 3 , --COOH,--COOR,--CONHR,--CONR 2 , and --OH; and where R represents lower alkyl having 1-6 carbon atoms.
Inventors
- 👤 Paul W. Manley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 08:29
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; A; A61; A61P; A61P9/00; A61P9/12; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
59 words
A compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof wherein X represents one to three substituents selected from the group consisting of R, OR, SR, NHR, NR 2 , Cl, Br, F, NO 2 , COCH 3 , COOH, COOR, CONHR, CONR 2 , and OH and wherein R represents lower alkyl having 1-6 carbon atoms.
Claim 2
Dependent Claim
59 words
A compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof wherein X represents one to three substituents selected from the group consisting of R, OR, SR, NHR, NR 2 , Cl, Br, F, NO 2 , COCH 3 , COOH, COOR, CONHR, CONR 2 , and OH and wherein R represents lower alkyl having 1-6 carbon atoms.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 which is 3,4-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-1,3-dimethyl-4-[(2,4,6-trimethyl phenyl)imino]-2(1H)-pyrimidinone.
Claim 4
Independent Claim
78 words
A method of treating hypertension in animals comprising administering to a hypertensive animal a therapeutically effective anti-hypertensive amount of a compound of the formula ##STR5## and the pharmaceutically acceptable salts thereof wherein X represents one to three substituents selected from the group consisting of R, OR, --SR, --NHR, --NR 2 , Cl, Br, F, NO 2 , --COCH 3 , --COOH, --COOR, --CONHR, --CONR 2 , or --OH and wherein R represents lower alkyl having 1-6 carbon atoms.
Claim 5
Independent Claim
78 words
A method of treating hypertension in animals comprising administering to a hypertensive animal a therapeutically effective anti-hypertensive amount of a compound of the formula ##STR5## and the pharmaceutically acceptable salts thereof wherein X represents one to three substituents selected from the group consisting of R, OR, --SR, --NHR, --NR 2 , Cl, Br, F, NO 2 , --COCH 3 , --COOH, --COOR, --CONHR, --CONR 2 , or --OH and wherein R represents lower alkyl having 1-6 carbon atoms.
Claim 6
Dependent Claim
28 words
A method of treating hypertension according to claim 1 comprising administering to a hypertensive animal a therapeutically effective antihypertensive amount of 3,4-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-1,3-dimethyl-4-[(2,4,6-trimethylphenyl)imino]-2(IH)-pyrimidinone or the pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
EP0123402A2
Cited
EP0166564A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-23 | 1991-05-25 | 1991-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-23 | 1995-05-25 | 1995-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-23 | 1999-05-25 | 1999-11-24 | $7700.00 | Window Closed / Lapsed |