US4708871A
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Antigenically active amino acid sequences
Assignee: Mimotopes Pty Ltd
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Filing: 1984-03-08
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Granted: 1987-11-24
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Expires: 2004-03-08
Abstract
Abstract PCT No. PCT/AU84/00038 Sec. 371 Date Nov. 8, 1984 Sec. 102(e) Date Nov. 8, 1984 PCT Filed Mar. 8, 1984 PCT Pub. No. WO84/03506 PCT Pub. Date Sep. 13, 1984.A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, characterised in that at least a portion of said peptide is selected from the group consisting of five-, six- or seven-long antigenically active amino acid sequences of said VP1 protein, and antigenically active modified sequences thereof.
Inventors
- 👤 Hendrik Geysen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:24
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; A61K39/12; A61K39/125; A61K39/135; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56983; G01N33/68; G01N33/6878; A61K2039/55; A61K2039/552; A61K2039/555; A61K2039/55505; A61K2039/55511; A61K2039/55566; A61K2039/60; A61K2039/6031; A61K2039/6081; C12; C12N; C12N2770/00; C12N2770/00011; C12N2770/32011; C12N2770/32111; C12N2770/32122; C12N2770/32134; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/22; Y10S930/222
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
125 words
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type O 1 , wherein said peptide is selected from amino acid sequences of the group consisting of: (i) G - D - L - Q - V - L - A; (ii) G - D - L - Q - V - L; (iii) D - L - Q - V - L - A; (iv) D - L - Q - V - L; and (v) antigenically acitve modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amino acid to provide said antigenically active modified sequences.
Claim 2
Dependent Claim
125 words
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type O 1 , wherein said peptide is selected from amino acid sequences of the group consisting of: (i) G - D - L - Q - V - L - A; (ii) G - D - L - Q - V - L; (iii) D - L - Q - V - L - A; (iv) D - L - Q - V - L; and (v) antigenically acitve modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amino acid to provide said antigenically active modified sequences.
Claim 3
Dependent Claim
127 words
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type A 10 (A 61 ), wherein said peptide is selected from amino acid sequences of the group consisting of: (i) G - D - L - G - S - I - A; (ii) G - D - L - G - S - I; (iii) D - L - G - S - I - A; (iv) D - L - G - S - I; and (v) antigenically active modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amono acid to provide said antigenically active modified sequences.
Claim 4
Dependent Claim
127 words
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type A 10 (A 61 ), wherein said peptide is selected from amino acid sequences of the group consisting of: (i) G - D - L - G - S - I - A; (ii) G - D - L - G - S - I; (iii) D - L - G - S - I - A; (iv) D - L - G - S - I; and (v) antigenically active modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amono acid to provide said antigenically active modified sequences.
Claim 5
Dependent Claim
125 words
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type C 1 , wherein said peptide is selected from amino acid sequence of the group consisting of: (i) D - L - A - H - L - T - A; (ii) D - L - A - H - L - T; (iii) L - A - H - L - T - A; (iv) L - A - H - L - T; and (v) antigenically active modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amino acid to provide said antigenically active modified sequences.
Claim 6
Dependent Claim
125 words
A synthetic peptide which displays the antigenicity of the VP1 protein of foot-and-mouth disease virus, Type C 1 , wherein said peptide is selected from amino acid sequence of the group consisting of: (i) D - L - A - H - L - T - A; (ii) D - L - A - H - L - T; (iii) L - A - H - L - T - A; (iv) L - A - H - L - T; and (v) antigenically active modified sequences based on any one of the sequences (i) to (iv) above in which one of the amino acids in said sequences (i) to (iv) above is replaced by another amino acid to provide said antigenically active modified sequences.
Claim 7
Dependent Claim
107 words
A synthetic peptide according to claim 1, wherein said peptide is selected from hexapeptide sequences based on the formula: ##STR4## in which: G at position (1) is replaced by A, H, I, K, M, N, P, Q, S or T; or D at position (2) is replaced by A, C, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V or Y; or Q at position (4) is replaced by D, K, A, M, E, N, S or R; or V at position (5) is replaced by A, D, E, F, I, K, L, M, N, Q, R, S, T or Y.
Claim 8
Dependent Claim
107 words
A synthetic peptide according to claim 2, wherein said peptide is selected from the group consisting of hexapeptide sequences baseed on the formula: ##STR5## in which: G at position (1) is replaed by A, C, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W or Y; or D at position (2) is replaced by L; or G at position (4) is replaced by A; or S at position (5) is replaced by T, G or A; or I at position (6) is replaced by A, C, D, E, F, K, L, M, Q, R, S, T, V, W or Y.
Claim 9
Dependent Claim
69 words
A synthetic peptide according to claim 3, wherein said peptide is selected from the group consisting of hexapeptide sequences based on the formula: ##STR6## in which: D at position (1) is replaced by H or V; or H at position (4) is replaced by A, C, D, E, F, K, L, M, N, Q, R, S, T, V or Y; or T at position (6) is replaced by S.
Claim 10
Dependent Claim
26 words
A vaccine for treating animals against infection by foot-and-mouth disease virus, comprising at least one synthetic peptide according to any one of claims 1 to 6.
Claim 11
Dependent Claim
14 words
A vaccine according to claim 7, further comprising a physiologically acceptable carrier and/or adjuvant.
Claim 12
Dependent Claim
20 words
A vaccine according to claim 8, wherein said at least one synthetic peptide is linked to said physiologically acceptable carrier.
Claim 13
Dependent Claim
23 words
A method of treating animals against infection by foot-and-mouth disease virus, which comprises administering to said animals a vaccine according to claim 7.
Claim 14
Dependent Claim
48 words
A diagnostic or other immunological testing composition for detecting the presence of foot-and-mouth disease virus or of antibodies against foot-and-mouth disease virus in an animal, comprising at least one synthetic peptide according to any one of claims 1 to 6 as an antigenically active component of said composition.
Claim 15
Dependent Claim
20 words
A vaccine according to claim 7, wherein said at least one synthetic peptide is linked to a physiologically acceptable carrier.
Claim 16
Dependent Claim
23 words
A method of treating animals against infection by foot-and-mouth disease virus, which comprises administering to said animals a vaccine according to claim 8.
Claim 17
Dependent Claim
23 words
A method of treating animals against infection by foot-and-mouth disease virus, which comprises administering to said animals a vaccine according to claim 9.
Claim 18
Dependent Claim
60 words
The synthetic peptide according to claim 1, 2, 3, 4, 5, or 6, additionally including one or more additional amino acids either at the carboxyl end, at the amino end or at both the carboxyl and the amino ends of said sequence, wherein said one or more additional amino acids do not substantially alter the antigenicity of said synthetic peptide.
Claim 19
Dependent Claim
21 words
A vaccine for treating animals against infection by foot-and-mouth disease virus, comprising at least one synthetic peptide according to claim 15.
Claim 20
Dependent Claim
23 words
A method of treating animals against infection by foot-and-mouth disease virus, which comprises administering to said animals a vaccine according to claim 16.
Claim 21
Dependent Claim
43 words
A diagnostic or other immunological testing composition for detecting the presence of foot-and-mouth disease virus or of antibodies against foot-and-mouth disease virus in an animal, comprising at least one synthetic peptide according to claim 15, as an antigenically active component of said composition.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1990-11-23 | 1991-05-25 | 1991-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-23 | 1995-05-25 | 1995-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-23 | 1999-05-25 | 1999-11-24 | $7700.00 | Window Closed / Lapsed |