US4707353A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiographic imaging agents
Assignee: Mallinckrodt Inc
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Filing: 1985-05-17
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Granted: 1987-11-17
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Expires: 2005-05-17
Abstract
Abstract A composition useful for tissue imaging, comprising tin metal or an alloy containing tin and an ascorbate, gentisate or reductate stabilizer. Preferably, such compositions also comprise a tissue-specific carrier and a stannous compound.
Inventors
- 👤 Joseph E. Bugaj
- 👤 Terry W. Grogg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 05:39
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/02; A61K51/04; A61K51/08; A61K51/081; A61K51/10; A61K2123/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
65 words
A composition, useful in the preparation of technetium-99m-based imaging agents, comprising: (a) a metal selected from the groups consisting of tin and tin-containing alloys, said metal being employed in an amount effective to reduce the technetium to be added to form an imaging agent; and (b) a stabilizing amount of stabilizer selected from the group consisting of gentisate, ascorbate, and reductate compounds, and mixtures thereof.
Claim 2
Dependent Claim
65 words
A composition, useful in the preparation of technetium-99m-based imaging agents, comprising: (a) a metal selected from the groups consisting of tin and tin-containing alloys, said metal being employed in an amount effective to reduce the technetium to be added to form an imaging agent; and (b) a stabilizing amount of stabilizer selected from the group consisting of gentisate, ascorbate, and reductate compounds, and mixtures thereof.
Claim 3
Dependent Claim
11 words
A composition, as in claim 1, further comprising a tissue-specific carrier.
Claim 4
Dependent Claim
11 words
A composition, as in claim 1, further comprising a stannous compound.
Claim 5
Dependent Claim
22 words
A composition, as in claim 1, wherein said stabilizer is selected from the group consisting of gentisic acid and pharmaceutically-acceptable salts thereof.
Claim 6
Dependent Claim
27 words
A composition, as in claim 1, wherein said stabilizer is selected from the group consisting of ascorbic acid, erythorbic acid, and the pharmaceutically-acceptable salts and esters thereof.
Claim 7
Dependent Claim
13 words
A composition, as in claim 2, wherein said tissue-specific carrier is an organophosphonate.
Claim 8
Dependent Claim
46 words
A composition, as in claim 6, wherein said organophosphonate is selected from the group consisting of methane diphosphonic acid, hydroxymethane diphosphonic acid, ethane-1-hydroxy-1,1-diphosphonic acid, methane amino diphosphonic acid, methane-N-methyl amino diphosphonic acid, methane-N,N-dimethylamino diphosphonic acid, propane-1-hydroxy-3-amino-1,1-diphosphonic acid, ethane-1-hydroxy-2-amino-1,1-diphosphonic acid, and the pharmaceutically-acceptable salts and mixtures thereof.
Claim 9
Dependent Claim
17 words
A composition, as in claim 2, wherein said tissue-specific carrier is a protein, peptide, or amino acid.
Claim 10
Dependent Claim
30 words
A composition, as in claim 3, wherein said stannous compound is selected from the group consisting of stannous chloride, stannous fluoride, stannous citrate, stannous tartrate, stannous oxide, and mixtures thereof.
Claim 11
Dependent Claim
13 words
A composition, as in claim 3, wherein said stannous compound is an organophosphonate.
Claim 12
Dependent Claim
14 words
A composition, as in claim 9, wherein said metal is coated with stannous oxide.
Claim 13
Dependent Claim
13 words
A composition, as in claim 9, wherein said stannous compound is stannous chloride.
Claim 14
Dependent Claim
63 words
A composition, as in claim 9, comprising: (a) a metal selected from the group consisting of tin and tin-containing alloys; (b) a stabilizer selected from the group consisting of gentisate, ascorbate, and reductate compounds, and mixtures thereof; (c) a diphosphonate tissue-specific carrier; and (d) a stannous compound; wherein the molar ratio of a diphosphonate carrier to said stannous compound is at least 65:1.
Claim 15
Dependent Claim
49 words
A composition, useful in the preparation of technetium-99m-based imaging agents, comprising: (a) a stabilizer selected from the group consisting of gentisate, ascorbate and reductate compounds, and mixtures thereof; dissolved in (b) an oxidized pertechnetate solution; and (c) a metal selected from the group consisting of tin and tin-containing alloys.
Claim 16
Dependent Claim
49 words
A composition, useful in the preparation of technetium-99m-based imaging agents, comprising: (a) a stabilizer selected from the group consisting of gentisate, ascorbate and reductate compounds, and mixtures thereof; dissolved in (b) an oxidized pertechnetate solution; and (c) a metal selected from the group consisting of tin and tin-containing alloys.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-16 | 1991-05-18 | 1991-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-16 | 1995-05-18 | 1995-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-16 | 1999-05-18 | 1999-11-17 | $7700.00 | Window Closed / Lapsed |