US4703267A
Expired / Lapsed
US
⏱️ 0.0 years remaining
High dynamic range in NMR data acquisition
Assignee: Advanced NMR Systems Inc
•
Filing: 1985-07-17
•
Granted: 1987-10-27
•
Expires: 2005-07-17
Abstract
Abstract In order to increase the efficiency with which NMR information is received, the peak amplitude of the received NMR signal is reduced. This reduction is obtained by varying the phase of the nuclear spin systems which produce the NMR signal. The phase variation may be obtained by applying a spatially inhomogeneous rf pulse. It may alternatively be obtained by applying a tailored rf pulse having either an amplitude spectrum or a phase spectrum which varies with frequency. It may alternatively be obtained by applying gradient pulses. The phase variation may be produced at one or more of several times during the data acquisition. In addition to reducing the peak amplitude of the NMR signal, the phase variation results in reduced noise from an FFT performed during processing.
Inventors
- 👤 Andrew A. Maudsley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:43
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/4818; G01R33/482; G01R23/00; G01R23/16; G01R33/54; G01R33/56; G01R33/565; G01R33/5659; G01R33/28; G01R33/32; G01R33/36; G01R33/3621
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
86 words
A method of receiving NMR signals comprising: exciting the nuclei of at least some of the atoms of an object during a first time interval to produce an NMR during a second time interval following the first time interval; varying the phase of the nuclei of at least some of the atoms of the object to reduce the ratio of the peak amplitude of the received NMR signal to its average power; and receiving at least part of the NMR signal during the second time interval.
Claim 2
Independent Claim
86 words
A method of receiving NMR signals comprising: exciting the nuclei of at least some of the atoms of an object during a first time interval to produce an NMR during a second time interval following the first time interval; varying the phase of the nuclei of at least some of the atoms of the object to reduce the ratio of the peak amplitude of the received NMR signal to its average power; and receiving at least part of the NMR signal during the second time interval.
Claim 3
Dependent Claim
23 words
The method of claim 1 in which varying the phase of the nuclei comprises applying a spatially inhomogeneous rf pulse to the object.
Claim 4
Dependent Claim
40 words
The method of claim 2, further comprising applying a pulsed gradient field during the inhomogeneous rf pulse for selecting a slice of the object in which the phase of the nuclei of at least some of the atoms is varied.
Claim 5
Dependent Claim
21 words
The method of claim 2 in which exciting the nuclei comprises applying a homogeneous rf pulse after the inhomogeneous rf pulse.
Claim 6
Dependent Claim
66 words
The method of claim 1 in which varying the phase of the nuclei comprises applying a phase scrambling rf pulse to the object, the phase scrambling rf pulse including a plurality of frequencies and having a respective phase and a respective amplitude for each of the frequencies, one of the respective phase and the respective amplitude varying with frequency for varying the phase of the nuclei.
Claim 7
Dependent Claim
86 words
The method of claim 5 in which the respective phases of the frequencies together define a phase spectrum and the respective amplitudes of the frequencies together define an amplitude spectrum, the method further comprising defining the phase spectrum and the frequency spectrum and transforming the phase spectrum and the amplitude spectrum to obtain a time-varying rf pulse waveform having real and imaginary components, the applying of the phase scrambling rf pulse comprising applying the real and imaginary components of the rf pulse waveform to the object.
Claim 8
Dependent Claim
38 words
The method of claim 5 in which the frequencies of the phase scrambling rf pulse cover a range of frequencies each having the same respective phase, the respective amplitudes of the frequencies within the range varying with frequency.
Claim 9
Dependent Claim
32 words
The method of claim 7, further comprising applying a pulsed gradient field during the phase scrambling rf pulse for varying the phase of the nuclei of at least some of the atoms.
Claim 10
Dependent Claim
22 words
The method of claim 8 in which exciting the nuclei comprises applying a homogeneous rf pulse after the phase scrambling rf pulse.
Claim 11
Dependent Claim
61 words
The method of claim 7, further comprising applying a pulsed gradient field along a first dimension during the phase scrambling rf pulse for varying the phase of the nuclei along the first dimension and applying a slice selecting rf pulse together with a pulsed gradient field along a second dimension orthogonal to the first dimension after the phase scrambling rf pulse.
Claim 12
Dependent Claim
38 words
The method of claim 5 in which the frequencies of the phase scrambling rf pulse cover a range of frequencies each having the same respective amplitude, the respective phases of the frequencies in the range varying with frequency.
Claim 13
Dependent Claim
18 words
The method of claim 11 in which the pulse scrambling rf pulse is a spatially non-selective excitation pulse.
Claim 14
Dependent Claim
16 words
The method of claim 11 in which the phase scrambling rf pulse is a refocusing pulse.
Claim 15
Dependent Claim
40 words
The method of claim 11 in which the respective phases of the frequencies in the range vary with frequency according to a slowly varying random phase function obtained by interpolating between a number of points from a purely random function.
Claim 16
Dependent Claim
44 words
The method of claim 11 in which the respective phases of the frequencies in the range vary with frequency according to a function which results in a reduction of the ratio of the peak amplitude of the received NMR signal to its average power.
Claim 17
Dependent Claim
47 words
The method of claim 1 further comprising encoding NMR information into the phase of excited nuclei by applying at least one pulsed gradient field to the object, the step of varying the phase of the nuclei comprising timing the pulsed gradient field to produce a phase variation.
Claim 18
Dependent Claim
18 words
The method of claim 16 in which applying the pulsed gradient field comprises providing high order gradient components.
Claim 19
Dependent Claim
21 words
The method of claim 1 further comprising encoding spatial information into the phase of at least some of the excited nuclei.
Claim 20
Dependent Claim
24 words
The method of claim 1, further comprising correcting the phase variation in the received NMR signal resulting from varying the phase of the nuclei.
Claim 21
Dependent Claim
20 words
The method of claim 19 in which correcting the phase variations comprises obtaining the magnitude of the received NMR signal.
Claim 22
Dependent Claim
36 words
The method of claim 19 in which correcting the phase variations comprises obtaining an image containing a plurality of points from the received NMR signal and correcting the phase variation at each point of the image.
Claim 23
Dependent Claim
66 words
The method of claim 1 in which the steps of exciting and varying the phase are performed together, the steps of exciting and varying the phase together comprising applying a first pulse for orienting spin axes of different nuclei differently and then applying a second pulse for bringing the spin axes of the nuclei into a single plane with different phases corresponding to their different orientations.
Claim 24
Dependent Claim
21 words
The method of claim 22 in which applying the first pulse comprises applying a spatially inhomogeneous rf pulse to the object.
Claim 25
Dependent Claim
55 words
The method of claim 22 in which applying the first pulse comprises applying an amplitude variant rf pulse having a plurality of frequencies, and having a respective amplitude for each of the frequencies, the respective amplitude varying with frequency, the amplitude variant rf pulse being applied in the presence of a pulsed magnetic gradient field.
Claim 26
Independent Claim
84 words
A method of NMR imaging, comprising: exciting the nuclei of at least some of the atoms of an object to produce an NMR signal; encoding spatial information into at least some of the excited nuclei; varying the phase of the nuclei of at least some of the atoms of the object to reduce the peak amplitude of the received NMR signal; receiving at least part of the NMR signal including the encoded spatial information; and generating an image based on the encoded spatial information.
Claim 27
Independent Claim
84 words
A method of NMR imaging, comprising: exciting the nuclei of at least some of the atoms of an object to produce an NMR signal; encoding spatial information into at least some of the excited nuclei; varying the phase of the nuclei of at least some of the atoms of the object to reduce the peak amplitude of the received NMR signal; receiving at least part of the NMR signal including the encoded spatial information; and generating an image based on the encoded spatial information.
Claim 28
Independent Claim
82 words
A method of scrambling the phases of a plurality of magnetically resonant spin systems, comprising: applying a phase scrambling electromagnetic pulse to the spin systems, the pulse including a range of frequencies, each having a respective amplitude and a respective phase, one of the respective amplitude and the respective phase varying with frequency as ##EQU5## where a and b are coefficients, m is a number of phase distinct segments of the range and n takes the integer values from -(m/2)+1 to m/2.
Claim 29
Independent Claim
82 words
A method of scrambling the phases of a plurality of magnetically resonant spin systems, comprising: applying a phase scrambling electromagnetic pulse to the spin systems, the pulse including a range of frequencies, each having a respective amplitude and a respective phase, one of the respective amplitude and the respective phase varying with frequency as ##EQU5## where a and b are coefficients, m is a number of phase distinct segments of the range and n takes the integer values from -(m/2)+1 to m/2.
Claim 30
Dependent Claim
52 words
The method of claim 26 in which each spin system is the nucleus of an atom, the method further comprising exciting the nuclei of at least some of the atoms to produce an NMR signal, the phase scrambling electromagnetic pulse being applied for reducing the peak amplitude of the received NMR signal.
Claim 31
Dependent Claim
27 words
The method of claim 27, further comprising encoding information in the phases of at least some of the nuclei for providing information in the received NMR signal.
References Cited (Backward Citations)
US4291272A
Cited
US4528509A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-10-26 | 1991-04-27 | 1991-10-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-10-26 | 1995-04-27 | 1995-10-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-10-26 | 1999-04-27 | 1999-10-27 | $7700.00 | Window Closed / Lapsed |