US4702908A
Expired / Lapsed
US
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Composition containing platelet factor 4 and method for restoring suppressed immune responses
Assignee: New York University
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Filing: 1985-11-01
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Granted: 1987-10-27
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Expires: 2005-11-01
Abstract
Abstract Compositions and methods for modulating immune responses in a mammal comprising immunomodulating-effective amounts of platelet factor 4 are disclosed herein. Immunomodulation includes one or more aspects of restoration of suppressed immune responses, inhibition of immune suppression (due to exposure of a mammal of an agent that causes suppressor cell activation) and augmentation of normal immune response.
Inventors
- 👤 G. Jeanette Thorbecke
- 👤 Marjorie Zucker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:41
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
42 words
A parenteral dosage form for modulating immune response in a human comprising an effective amount for modulating immune response of platelet factor 4, and a pharmaceutically acceptable carrier or diluent, wherein said effective amount ranges between about 500 and about 5000 micrograms.
Claim 2
Dependent Claim
42 words
A parenteral dosage form for modulating immune response in a human comprising an effective amount for modulating immune response of platelet factor 4, and a pharmaceutically acceptable carrier or diluent, wherein said effective amount ranges between about 500 and about 5000 micrograms.
Claim 3
Dependent Claim
28 words
The dosage form of claim 1, wherein said amount is effective for restoring immune response suppressed by activation in said human of peripheral T-cells of the suppressor phenotype.
Claim 4
Dependent Claim
31 words
The dosage form of claim 1, wherein said amount is effective for preventing immune response suppression caused by exposure of said mammal to an agent or antigen which induces suppressor T-cells.
Claim 5
Dependent Claim
23 words
The dosage form of claim 1, wherein said amount is effective for augmenting the immune response of said human to an antigenic agent.
Claim 6
Dependent Claim
20 words
The dosage form of claim 1, wherein said carier is physiological buffered saline solution containing human serum albumin for stabilization.
Claim 7
Dependent Claim
15 words
The dosage form of claim 1, said factor being in the form of platelet releasate.
Claim 8
Dependent Claim
14 words
The dosage form of claim 1, said factor being contained in normal human serum.
Claim 9
Dependent Claim
78 words
A parenteral dosage form for augmenting the immune response of a mammal to an antigen by suppression of the activation of suppressor T-cells in said mammal which accompanies exposure of the immune system of a mammal to said antigen, said dosage form comprising an amount of said antigen sufficient for immunization of said mammal and an amount of platelet factor 4 effective for augmenting said response and being within the range between about 0.18 and about 5000 micrograms.
Claim 10
Dependent Claim
78 words
A parenteral dosage form for augmenting the immune response of a mammal to an antigen by suppression of the activation of suppressor T-cells in said mammal which accompanies exposure of the immune system of a mammal to said antigen, said dosage form comprising an amount of said antigen sufficient for immunization of said mammal and an amount of platelet factor 4 effective for augmenting said response and being within the range between about 0.18 and about 5000 micrograms.
Claim 11
Dependent Claim
12 words
The dosage form of claim 8, said dosage form comprising a vaccine.
Claim 12
Dependent Claim
13 words
The dosage form of claim 4, said dosage form comprising a vaccine adjuvant.
Claim 13
Dependent Claim
13 words
The dosage form of claim 1 in a form suitable for intravenous administration.
Claim 14
Dependent Claim
13 words
The dosage form of claim 8 in a form suitable for intravenous administration.
Claim 15
Dependent Claim
15 words
The dosage form of claim 8, said factor being in the form of platelet releasate.
Claim 16
Dependent Claim
18 words
The dosage form of claim 8, said carrier being physilogical buffered saline solution containing serum albumin for stabilization.
Claim 17
Independent Claim
65 words
A method for modulating immune response in a mammal in need of such treatment comprising parenterally administering to said mammal a parenteral dosage form comprising an effective amount for suppressing or inhibiting the activation of suppressor T-cells in said mammal of platelet factor four in a pharmaceutically acceptable carrier or diluent, said effective amount ranging between about 0.18 and about 5000 micrograms in one dose.
Claim 18
Independent Claim
65 words
A method for modulating immune response in a mammal in need of such treatment comprising parenterally administering to said mammal a parenteral dosage form comprising an effective amount for suppressing or inhibiting the activation of suppressor T-cells in said mammal of platelet factor four in a pharmaceutically acceptable carrier or diluent, said effective amount ranging between about 0.18 and about 5000 micrograms in one dose.
Claim 19
Dependent Claim
33 words
The method of claim 15, comprising administering to said mammal an amount of platelet factor four sufficient to improve or restore immune response in a mammal immunosuppressed through activation of said T-suppressor cells.
Claim 20
Dependent Claim
42 words
The method of claim 15, comprising administering to said mammal an amount of platelet factor four sufficient to inhibit immune suppression in said mammal caused by exposure of said mammal to an agent which is immunosuppressive because it causes suppressor T-cell activation.
Claim 21
Dependent Claim
43 words
The method of claim 15, wherein said mammal is a normal mammal, said method further comprising administering to said mammal an antigenic agent causing immune response by said mammal, wherein the amount of platelet factor four is sufficient to enhance said immune response.
Claim 22
Dependent Claim
24 words
The method of claim 15, wherein said amount ranges between about 0.18 and about 18 micrograms of platelet factor four per treatment for mice.
Claim 23
Dependent Claim
24 words
The method of claim 15, wherein said amount ranges between about 500 and about 5000 micrograms of platelet factor four per treatment for man.
Claim 24
Dependent Claim
12 words
The method of claim 15, wherein said dosage form is adminstered intravenously.
Claim 25
Dependent Claim
22 words
The method of claim 17, comprising administering said dosage form to said mammal prior to exposure of said mammal to said agent.
Claim 26
Dependent Claim
20 words
The method of claim 17 comprising administering said dosage form to said mammal substantially simultaneously with administration of said agent.
Claim 27
Dependent Claim
18 words
The method of claim 17 comprising administering said dosage form to said mammal after adminstration of said agent.
Claim 28
Dependent Claim
19 words
The method of claim 18 comprising administering said dosage form to said mammal prior to administration of said agent.
Claim 29
Dependent Claim
20 words
The method of claim 18 comprising administering said dosage form to said mammal substantially simultaneously with administration of said agent.
Claim 30
Dependent Claim
18 words
The method of claim 18 comprising adminstering said dosage form to said mammal after administration of said agent.
Claim 31
Dependent Claim
14 words
The method of claim 15 further comprising monitoring the immune response of said mammal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-10-26 | 1991-04-27 | 1991-10-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-10-26 | 1995-04-27 | 1995-10-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-10-26 | 1999-04-27 | 1999-10-27 | $7700.00 | Window Closed / Lapsed |