US4701453A
Expired / Lapsed
US
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Substituted indeno-pyridazinones
Assignee: Warner Lambert Co LLC
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Filing: 1986-04-14
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Granted: 1987-10-20
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Expires: 2006-04-14
Abstract
Abstract Substituted 2,5-dihydro- and 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents.
Inventors
- 👤 Ila Sircar
- 👤 James A. Bristol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:14
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/00; C07D233/54; C07D233/56; C07D237/00; C07D237/26; C07D249/00; C07D249/02; C07D249/08; C07D401/00; C07D401/02; C07D401/04; C07D403/00; C07D403/02; C07D403/04; C07D403/12; C07D491/00; C07D491/02; C07D491/10
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
68 words
A compound having the structural formula ##STR17## wherein A is ##STR18## where B is ##STR19## where alkyl is of from one to four carbon atoms; ##STR20## where R 18 is hydrogen, hydroxy, halogen, alkyl of from one to four carbon atoms, or alkoxy of from one to four carbon atoms; alkylamino of from one to four carbon atoms; or amino alkylamino of from one to four carbon atoms.
Claim 2
Dependent Claim
68 words
A compound having the structural formula ##STR17## wherein A is ##STR18## where B is ##STR19## where alkyl is of from one to four carbon atoms; ##STR20## where R 18 is hydrogen, hydroxy, halogen, alkyl of from one to four carbon atoms, or alkoxy of from one to four carbon atoms; alkylamino of from one to four carbon atoms; or amino alkylamino of from one to four carbon atoms.
Claim 3
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(1-piperidinyl)-3H-indeno-(1,2-c)pyridazinone, or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(3-hydroxy-1-piperidinyl)-3H-indeno(1,2-c)pyridazinone, or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(1,4-dioxa-8-azaspiro(4,5)-dec-8-yl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(4-thiomorpholinyl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(4-(2-pyridyl)-1-piperazinyl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
19 words
A compound as defined by claim 1 having the name 2,4,4a,5-tetrahydro-7-(1-morpholinyl)-3H-indeno-(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(3-aminopropyl)amino)3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(4-methyl-1-piperazinyl)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
19 words
A compound as defined in claim 1 having the name 2,4,4a,5-tetrahydro-7-(butylamino)-3H-indeno(1,2-c)pyridazin-3-one, or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
29 words
A pharmaceutical composition for increasing cardiac contractility or for lowering blood pressure comprising an effective amount of a compound as claimed in claim 1 and a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
27 words
A method for increasing cardiac contractility and lowering blood pressure in a patient which comprises administering an effective amount of a pharmaceutical composition according to claim 11.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-10-19 | 1991-04-20 | 1991-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-10-19 | 1995-04-20 | 1995-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-10-19 | 1999-04-20 | 1999-10-20 | $7700.00 | Window Closed / Lapsed |