US4701451A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel 6,16-dimethylcorticoids their preparation and use
Assignee: Bayer Pharma AG
•
Filing: 1985-10-29
•
Granted: 1987-10-20
•
Expires: 2005-10-29
Abstract
Abstract Compounds of Formula I ##STR1## wherein the bond is a single bond or a double bond, X is hydrogen, fluorine, chlorine, or bromine, R 1 is formyl, alkanoyl or alkoxyalkyl each of which contains 2-8 carbon atoms, or benzoyl, and Y is chlorine, hydroxy, formyl, alkanoyloxy of 2-8 carbon atoms, or benzoyloxy, have valuable anti-inflammatory properties.
Inventors
- 👤 Klaus Annen
- 👤 Henry Laurent
- 👤 Helmut Hofmeister
- 👤 Rudolf Wiechert
- 👤 Michael Toepert
- 👤 Hans Wendt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:07
CPC Classifications
C; C07; C07J; C07J5/00; C07J5/0046; C07J5/0061; C07J5/0069; C07J5/0076; A; A61; A61P; A61P17/00; A61P29/00; C07J21/00; C07J7/00; C07J7/008; C07J7/0085; C07J71/00; C07J71/0005; C07J71/001; C07J71/0015
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
40 words
A 6,16-dimethylcorticoid of the formula ##STR6## wherein represents a single bond or a double bond; X is hydrogen, fluorine, chlorine, or bromine; R 1 is (C 1-4 -alkoxy)methyl; and Y is chlorine, hydroxy, alkanoyloxy of 2-8 carbon atoms, or benzoyloxy.
Claim 2
Dependent Claim
40 words
A 6,16-dimethylcorticoid of the formula ##STR6## wherein represents a single bond or a double bond; X is hydrogen, fluorine, chlorine, or bromine; R 1 is (C 1-4 -alkoxy)methyl; and Y is chlorine, hydroxy, alkanoyloxy of 2-8 carbon atoms, or benzoyloxy.
Claim 3
Dependent Claim
11 words
A compound of claim 1, which is 21-acetoxy-9α-bromo-11β-hydroxy-17α-methoxymethoxy-6.alpha.,16β-dimethyl-1,4-pregnadiene-3,20-dione or 21-acetoxy-9α-bromo-11β-hydroxy-17α-methoxy methoxy-6α,16β-dimethyl-4-pregnene-3,20-dione.
Claim 4
Dependent Claim
14 words
A compound of claim 1, which is 21-acetoxy-11β-hydroxy-17α-methoxymethoxy-6α,16β-dimethyl-1,4-pregnadiene-3,20-dione, 21-acetoxy-11β-hydroxy-17α-methoxymethoxy-6α,16β-dimethyl-4-pregnene-3,20-dione, 11β,21-dihydroxy-17α-methoxymethoxy-6α,16β-dimethyl-4-pregnene-3,20-dione, 11β,21-dihydroxy-17α-methoxymethoxy-6α,16β-dimethyl-1,4-pregnadiene-3,20-dione, 21-acetoxy-17α-ethoxymethoxy-11β-hydroxy-6α,16β-dimethyl-1,4-pregnadiene-3,20-dione, or 17α,ethoxymethoxy-11β,21-dihydroxy-6α,16β-dimethyl-1,4-pregnadiene-3,20-dione.
Claim 5
Dependent Claim
19 words
A pharmaceutical composition comprising an anti-inflammatorily effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
10 words
A pharmaceutical composition of claim 4 adapted for topical application.
Claim 7
Dependent Claim
12 words
A pharmaceutical composition of claim 4 adapted for application as an inhalant.
Claim 8
Dependent Claim
28 words
A method of treating inflammation in a patient in need of such treatment comprising administering to the patient an anti-inflammatorily effective amount of a compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-10-19 | 1991-04-20 | 1991-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-10-19 | 1995-04-20 | 1995-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-10-19 | 1999-04-20 | 1999-10-20 | $7700.00 | Window Closed / Lapsed |