US4698328A
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Method of increasing bone mass
Assignee: General Hospital Corp
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Filing: 1986-12-05
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Granted: 1987-10-06
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Expires: 2006-12-05
Abstract
Abstract A method for increasing bone mass in a human afflicted with osteoporosis or a similar disease which comprises administering to the human so afflicted an effective amount of a composition comprising a parathyroid hormone or physiologically active fragment thereof, or equivalents thereof, in combination with either (a) a hydroxylated Vitamin D compound, or a structural or functional analogue thereof, or (b) a dietary calcium supplement. Pharmaceutical compositions containing the necessary components are also disclosed.
Inventors
- 👤 Robert M. Neer
- 👤 John T. Potts, Jr.
- 👤 David M. Slovik
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 23:19
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/29; A61P; A61P19/00; A61P19/08; A61P19/10; A61P3/00; A61P3/02; A61P3/12; A61P3/14; A61P43/00; A61P5/00; A61P5/10; A61P5/12
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
48 words
A method of increasing bone mass in a human, which comprises: administering to said human a physiologically active parathyroid hormone or physiologically active fragment thereof, in combination with an agent selected from the group consisting of: (a) a hydroxylated Vitamin D compound, and (b) a dietary calcium supplement.
Claim 2
Independent Claim
48 words
A method of increasing bone mass in a human, which comprises: administering to said human a physiologically active parathyroid hormone or physiologically active fragment thereof, in combination with an agent selected from the group consisting of: (a) a hydroxylated Vitamin D compound, and (b) a dietary calcium supplement.
Claim 3
Dependent Claim
26 words
The method of claim 1, wherein said fragment consists of the first 34 amino acid residues of a parathyroid hormone obtainable from a human or animal.
Claim 4
Dependent Claim
13 words
The method of claim 1, wherein said fragment is obtainable from a human.
Claim 5
Dependent Claim
14 words
The method of claim 1, wherein said fragment has the amino acid sequence: ##STR3##
Claim 6
Dependent Claim
16 words
The method of claim 1, wherein said administration of said hormone or said fragment is parenteral.
Claim 7
Dependent Claim
29 words
The method of claim 5, wherein said administration of said hormone or said fragment is by subcutaneous, intramuscular, or intravenous injection, nasopharyngeal or mucosal absorption, or trans dermal absorption.
Claim 8
Dependent Claim
16 words
The method of claim 1, wherein said administration of said hormone or said fragment is nonparenteral.
Claim 9
Dependent Claim
13 words
The method of claim 7, wherein said administration is by ingestion of liposomes.
Claim 10
Dependent Claim
23 words
The method of claim 1, wherein said parathyroid hormone fragment is administered at a rate of from 100 to 700 units per day.
Claim 11
Dependent Claim
22 words
The method of claim 1, wherein said agent is selected from the group comprising of: 1-hydroxy Vitamin D and 1,25-dihydroxy Vitamin D.
Claim 12
Dependent Claim
12 words
The method of claim 10, wherein said agent is 1,25-dihydroxy Vitamin D.
Claim 13
Dependent Claim
28 words
The method of claim 1, wherein said agent is a hydroxylated Vitamin D compound which is administered at a rate of from 0.05 to 150 mcg per day.
Claim 14
Dependent Claim
23 words
The method of claim 12, wherein said hydroxylated Vitamin D compound is administered at the rate of 0.05 to 3.0 mcg per day.
Claim 15
Dependent Claim
24 words
The method of claim 13, wherein said hydroxylated Vitamin D compound is administered at the rate of from 0.05 to 2.0 mcg per day.
Claim 16
Dependent Claim
42 words
The method of claim 1, wherein said agent is a dietary calcium supplement comprising a non-toxic calcium compound which is administered at a rate of greater than 2,000 mg/day in order to achieve a high calcium intake of 38-50 mmoles/day in adults.
Claim 17
Dependent Claim
37 words
A pharmaceutical combination comprising: a physiologically active parathyroid hormone or physiologically active fragment thereof, in combination with an agent selected from the group consisting of: (a) a hydroxylated Vitamin D compound, and (b) a non-toxic calcium salt.
Claim 18
Dependent Claim
37 words
A pharmaceutical combination comprising: a physiologically active parathyroid hormone or physiologically active fragment thereof, in combination with an agent selected from the group consisting of: (a) a hydroxylated Vitamin D compound, and (b) a non-toxic calcium salt.
Claim 19
Dependent Claim
31 words
The combination of claim 16, wherein said parathyroid hormone fragment is a peptide consisting of the first 34 amino acid residues of a parathyroid hormone obtainable from a human or animal.
Claim 20
Dependent Claim
14 words
The combination of claim 16, wherein said hormone fragment is obtainable from a human.
Claim 21
Dependent Claim
14 words
The combination of claim 16, wherein said fragment has the amino acid sequence: ##STR4##
Claim 22
Dependent Claim
20 words
The pharmaceutical combination of claim 16, wherein said combination comprises from 100 to 700 units of said parathyroid hormone fragment.
Claim 23
Dependent Claim
20 words
The pharmaceutical combination of claim 20, wherein said combination comprises from 200 to 600 units of said parathyroid hormone fragment.
Claim 24
Dependent Claim
24 words
The pharmaceutical combination of any of claims 19 and 21, wherein said combination comprises from 400 to 500 units of said parathyroid hormone fragment.
Claim 25
Dependent Claim
22 words
The combination of claim 16, wherein said agent is selected from the group consisting of: 1-hydroxy Vitamin D or 1,25-dihydroxy Vitamin D.
Claim 26
Dependent Claim
12 words
The combination of claim 23, wherein said agent is 1,25-dihydroxy Vitamin D.
Claim 27
Dependent Claim
19 words
The combination of claim 16, wherein said agent is from 0.05 to 150 mcg of said Vitamin D compound.
Claim 28
Dependent Claim
19 words
The combination of claim 25, wherein said agent is from 0.05 to 3.0 mcg of said Vitamin D compound.
Claim 29
Dependent Claim
19 words
The combination of claim 26, wherein said agent is from 0.05 to 2.0 mcg of said Vitamin D compound.
Claim 30
Dependent Claim
17 words
The combination of claim 16, wherein said agent is comprises calcium coupled to a non-toxic counter ion.
Claim 31
Dependent Claim
20 words
The combination of claim 28, wherein said non-toxic counter ion is carbonate, citrate, phosphate, gluconate, lactate, chloride and glycerol phosphate.
Claim 32
Dependent Claim
12 words
The combination of claim 29, wherein said calcium salt is calcium carbonate.
Claim 33
Dependent Claim
18 words
The combination of claim 16, wherein said agent is from 12.5 to 50 mmoles of said calcium salt.
References Cited (Backward Citations)
US3956260A
Cited
US4241051A
Cited
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