US4696923A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids
Assignee: Merck and Co Inc
•
Filing: 1984-04-23
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Granted: 1987-09-29
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Expires: 2004-04-23
Abstract
Abstract Disclosed are antibiotic 6-[1-hydroxyethyl]-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acids and their pharmaceutically acceptable salts and esters (I): <IMAGE> I wherein: R8 is <IMAGE> and <IMAGE> I wherein: R8 is <IMAGE> and wherein n and m are independently selected from 0, 1, 2, 3, 4 and 5; X is -NR; and Y is -R, or -NRR; and wherein R is independently selected from hydrogen, alkyl, alkenyl, alkynyl, (having 1-6 carbon atoms); cycloalkyl and cycloalkenyl (having 3-6 carbon atoms); and heterocyclyl, heteroaryl (having 3-6 ring atoms, one or more of which is N, O or S).
Inventors
- 👤 Burton G. Christensen
- 👤 David H. Shih
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:05
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/20; C07D295/205; A; A61; A61P; A61P31/00; A61P31/04; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/12; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/40; C07D211/44; C07D211/46; C07D211/54; C07D279/00; C07D279/10; C07D279/12; C07D477/00; C07D477/10; C07D477/12; C07D477/16; C07D477/20
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
43 words
A compound having the formula: ##STR86## and pharmaceutically acceptable salts and esters thereof, wherein R 8 is ##STR87## and wherein n is 1 or 2 and m is 1; X is --NR; and Y is --R; and wherein R is hydrogen or methyl.
Claim 2
Dependent Claim
43 words
A compound having the formula: ##STR86## and pharmaceutically acceptable salts and esters thereof, wherein R 8 is ##STR87## and wherein n is 1 or 2 and m is 1; X is --NR; and Y is --R; and wherein R is hydrogen or methyl.
Claim 3
Dependent Claim
22 words
A pharmaceutical composition for antibacterial use comprising a pharmaceutically acceptable carrier and an antibacterially effective amount of a compound of claim 1.
Claim 4
Dependent Claim
22 words
A method of treating bacterial infections in animals and humans which comprises administering a therapeutically effective amount of compound of claim 1.
Claim 5
Dependent Claim
10 words
A compound of claim 1 wherein R 8 is: ##STR88##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-09-28 | 1991-03-30 | 1991-09-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-28 | 1995-03-30 | 1995-09-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-28 | 1999-03-30 | 1999-09-29 | $7700.00 | Window Closed / Lapsed |