US4692332A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunotherapeutic methods and compositions employing antigens characteristic of malignant neoplasms
Assignee: Milkhaus Laboratory Inc
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Filing: 1985-01-18
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Granted: 1987-09-08
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Expires: 2005-01-18
Abstract
Abstract A method and composition for treating malignant neoplasia and acquired immune deficiency syndrome by once daily administration of a substance (such as human chorionic gonadotropin) characteristic of the tumor or acquired immune deficiency syndrome-afflicted cell in an amount less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the existence of a negative wheal upon subcutaneous administration.
Inventors
- 👤 John McMichael
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:52
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/0005; A61K35/00; A61K35/66; A61K35/74; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/24; A61K39/0006; A61K39/0011; A61P; A61P31/00; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P37/04; A61P43/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
114 words
A method for tumor reduction in a disease victim comprising the steps of: administering to the disease victim a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin and pharmaceutically effective fragments and pharmaceutically effective derivatives thereof, in a pharmacuetically effective amount which is less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and co-administering a lysate of Staphylococcus aureus in an amount which is less than the lowest amount necessary to provoke a humoral immune response in combination with the member, as exemplified by the presence of a positive wheal upon subcutaneous administration.
Claim 2
Independent Claim
114 words
A method for tumor reduction in a disease victim comprising the steps of: administering to the disease victim a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin and pharmaceutically effective fragments and pharmaceutically effective derivatives thereof, in a pharmacuetically effective amount which is less than the lowest amount necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and co-administering a lysate of Staphylococcus aureus in an amount which is less than the lowest amount necessary to provoke a humoral immune response in combination with the member, as exemplified by the presence of a positive wheal upon subcutaneous administration.
Claim 3
Dependent Claim
111 words
A composition for tumor reduction in a disease victim comprising: a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin and pharmaceutically effective fragments and pharmaceutically effective derivatives thereof, in a pharmaceutically effectve amount which is less than the lowest amount of the substance necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and a lysate of Staphylococcus aureus in a pharmaceutically effective amount less than the lowest amount of the substance necessary to provoke a humoral immune response in combination with said member as exemplified by the presence of a positive wheal upon subcutaneous administation.
Claim 4
Dependent Claim
111 words
A composition for tumor reduction in a disease victim comprising: a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin and pharmaceutically effective fragments and pharmaceutically effective derivatives thereof, in a pharmaceutically effectve amount which is less than the lowest amount of the substance necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and a lysate of Staphylococcus aureus in a pharmaceutically effective amount less than the lowest amount of the substance necessary to provoke a humoral immune response in combination with said member as exemplified by the presence of a positive wheal upon subcutaneous administation.
Claim 5
Independent Claim
104 words
A method for tumor reduction in a disease victim comprising the steps of: administering to the disease victim a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin in a pharmaceutically effective amount which is less than lowest amount necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and co-administering a lysate of Staphylococcus aureus in an amount which is less than the lowest amount necessary to provoke a humoral immune response in combination with the member, as exemplified by the presence of a positive wheal upon subcutaneous administration.
Claim 6
Independent Claim
104 words
A method for tumor reduction in a disease victim comprising the steps of: administering to the disease victim a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin in a pharmaceutically effective amount which is less than lowest amount necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and co-administering a lysate of Staphylococcus aureus in an amount which is less than the lowest amount necessary to provoke a humoral immune response in combination with the member, as exemplified by the presence of a positive wheal upon subcutaneous administration.
Claim 7
Dependent Claim
102 words
A composition for tumor reduction in a disease victim comprising: a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin in a pharmaceutically effective amount which is less than the lowest amount of the substance necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and a lysate of Staphylococcus aureus in a pharmaceutically effective amount less than the lowest amount of the substance necessary to provoke a humoral immune response in combination with said member as exemplified by the presence of a positive wheal upon subcutaneous administration.
Claim 8
Dependent Claim
102 words
A composition for tumor reduction in a disease victim comprising: a member selected from the group consisting of human chorionic gonadotropin and equine chorionic gonadotropin in a pharmaceutically effective amount which is less than the lowest amount of the substance necessary to provoke a humoral immune response, as exemplified by the presence of a positive wheal upon subcutaneous administration; and a lysate of Staphylococcus aureus in a pharmaceutically effective amount less than the lowest amount of the substance necessary to provoke a humoral immune response in combination with said member as exemplified by the presence of a positive wheal upon subcutaneous administration.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-09-07 | 1991-03-09 | 1991-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-07 | 1995-03-09 | 1995-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-07 | 1999-03-09 | 1999-09-08 | $7700.00 | Window Closed / Lapsed |