US4692284A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and apparatus for forming droplets and microcapsules
Assignee: Abbott Biotech Inc
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Filing: 1986-04-30
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Granted: 1987-09-08
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Expires: 2006-04-30
Abstract
Abstract A method and apparatus for forming microcapsules from a fluid medium containing living culture material by the atomization of the medium and the treatment of the atomized droplets with a treatment fluid. A medium under pressure enters a chamber having a wall with a plurality of orifices formed therein. A vibrator vibrates the chamber. As the medium passes through the orifices the exit stream vibrates and forms small droplets. The droplets fall into a collection vessel on the other side of the wall, which contains treatment fluid for hardening the droplets into microcapsules. A flow of treatment fluid may be maintained through the collection vessel to prevent clumping of the droplets and to transport the hardened microcapsules for harvesting. Preferred operating pressures, orifice size and chamber configuration are shown.
Inventors
- 👤 William I. Braden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 09:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1682; A61K9/1694; B; B01; B01J; B01J13/00; B01J13/02; B01J13/04; Y; Y10; Y10S; Y10S425/00; Y10S425/804
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
139 words
Apparatus for forming microcapsules of a desired size from a fluid medium containing living culture material by the atomization of the medium, such apparatus comprising: a flow chamber for flowing the medium therethrough and including (a) a flow cap, having an inlet port and (b) a wall member having first and second opposing sides, said wall member being attached to the cap such that the cap and said first side define said chamber, said wall also having a plurality of orifices formed therethrough; pressure means, for pressurizing the flow chamber to drive the medium through the orifices; vibration means for vibrating the chamber to atomize the medium flowing through the orifices; and means for coupling the apparatus to a collection vessel on the second side of the wall so as to deliver to the collection vessel said atomizing flow.
Claim 2
Dependent Claim
139 words
Apparatus for forming microcapsules of a desired size from a fluid medium containing living culture material by the atomization of the medium, such apparatus comprising: a flow chamber for flowing the medium therethrough and including (a) a flow cap, having an inlet port and (b) a wall member having first and second opposing sides, said wall member being attached to the cap such that the cap and said first side define said chamber, said wall also having a plurality of orifices formed therethrough; pressure means, for pressurizing the flow chamber to drive the medium through the orifices; vibration means for vibrating the chamber to atomize the medium flowing through the orifices; and means for coupling the apparatus to a collection vessel on the second side of the wall so as to deliver to the collection vessel said atomizing flow.
Claim 3
Dependent Claim
18 words
Apparatus according to claim 1, wherein the orifices have a diameter in the range of approximately 100-500 microns.
Claim 4
Dependent Claim
23 words
Apparatus according to claim 2, wherein the pressure means includes means for providing pressure in the range of approximately 1 to 4 atmospheres.
Claim 5
Dependent Claim
13 words
Apparatus according to claim 3, wherein the wall member is a perforated diaphragm.
Claim 6
Dependent Claim
20 words
Apparatus according to claim 4, further including a collection vessel and means for flowing treatment fluid through the collection vessel.
Claim 7
Dependent Claim
13 words
Apparatus according to claim 1, wherein the wall member is a perforated diaphragm.
Claim 8
Dependent Claim
41 words
Apparatus according to claim 6, wherein the cap and wall define a roof and a floor, respectively, of the chamber and wherein the distance between the roof and the floor is less than approximately one-quarter of the diameter of the diaphragm.
Claim 9
Independent Claim
132 words
A method for forming microcapsules of a fluid medium containing living culture material by the atomization of the medium and the treatment of atomized droplets thereof with a treatment fluid, such method comprising the steps of: flowing the medium through an inlet port into a flow chamber having a flow cap and a wall member having first and second opposing sides, said wall member being attached to the cap such that the cap and said first side define said chamber, said wall also having a plurality of orifices formed therethrough; providing pressure in said chamber to drive the medium through the orifices, vibrating the chamber to atomize the medium driven through the orifices, and receiving said atomized flow in a vessel of the treatment fluid on the second side of the wall.
Claim 10
Independent Claim
132 words
A method for forming microcapsules of a fluid medium containing living culture material by the atomization of the medium and the treatment of atomized droplets thereof with a treatment fluid, such method comprising the steps of: flowing the medium through an inlet port into a flow chamber having a flow cap and a wall member having first and second opposing sides, said wall member being attached to the cap such that the cap and said first side define said chamber, said wall also having a plurality of orifices formed therethrough; providing pressure in said chamber to drive the medium through the orifices, vibrating the chamber to atomize the medium driven through the orifices, and receiving said atomized flow in a vessel of the treatment fluid on the second side of the wall.
Claim 11
Dependent Claim
18 words
The method of claim 8, wherein the orifices have a diameter in the range of approximately 100-500 microns.
Claim 12
Dependent Claim
13 words
The method of claim 9, wherein the wall member is a perforated diaphragm.
Claim 13
Dependent Claim
17 words
The method of claim 10, further including the step of flowing treatment fluid through the collection vessel.
Claim 14
Dependent Claim
23 words
The method of claim 11, wherein the step of providing pressure includes providing pressure in the range of approximately 1 to 4 atmospheres.
Claim 15
Dependent Claim
120 words
Apparatus for the production of sub-millimeter droplets from a fluid medium containing living culture material, such apparatus comprising: a shallow cap having a roof portion, a vibrator affixed to the cap, an orifice member affixed to the cap opposite the roof portion so as to define, together with the cap, a closed chamber, said orifice member including one or more orifices therethrough of a diameter functionally related to a desired droplet diameter, spacing means for providing a free-fall space below said orifice member, and pressure means for pressurizing the chamber so as to drive the medium therein as a fluid stream through the orifices whereby the droplets are produced by vibration of the fluid stream in the free fall space.
Claim 16
Dependent Claim
120 words
Apparatus for the production of sub-millimeter droplets from a fluid medium containing living culture material, such apparatus comprising: a shallow cap having a roof portion, a vibrator affixed to the cap, an orifice member affixed to the cap opposite the roof portion so as to define, together with the cap, a closed chamber, said orifice member including one or more orifices therethrough of a diameter functionally related to a desired droplet diameter, spacing means for providing a free-fall space below said orifice member, and pressure means for pressurizing the chamber so as to drive the medium therein as a fluid stream through the orifices whereby the droplets are produced by vibration of the fluid stream in the free fall space.
Claim 17
Dependent Claim
17 words
Apparatus according to claim 13 wherein the orifice member is removably and replaceably affixed to the cap.
Claim 18
Dependent Claim
26 words
Apparatus according to claim 14, further including a treatment vessel, coupled to the spacing means, for receiving said droplets and treating them with a treatment fluid.
Claim 19
Dependent Claim
19 words
Apparatus according to claim 15, wherein the diameter of the orifices is approximately one-half of the desired droplet diameter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-09-07 | 1991-03-09 | 1991-09-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-09-07 | 1995-03-09 | 1995-09-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-09-07 | 1999-03-09 | 1999-09-08 | $7700.00 | Window Closed / Lapsed |