US4690749A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymer-coated surfaces to control surface zeta potential
Assignee: UNITED STATES REPRESENTED BY ADMINISTRATOR OF NASA
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Filing: 1985-12-16
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Granted: 1987-09-01
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Expires: 2005-12-16
Abstract
Abstract A method for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising conducting electrophoresis employing electrophoretic surfaces coated with covalently bound hydrophilic, neutral polymers is described. An electrophoretic chamber for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising electrophoretic surfaces coated with covalently bound hydrophilic, neutral polymers, is also disclosed as well as particles exhibiting controlled electrophoretic mobility. The method and electrophoretic chamber not only eliminate electroosmosis, but allow for specific control of electroosmosis. The coated electrophoretic surface is stable relative to prior art coatings and over a broad range of pH. The point of optical focus for accurate mobility measurements is increased from a narrow stationary level to the entire chamber, facilitating accurate measurements by mechanical means. The method also reduces or eliminates assymetric fluid flows due to electroosmosis in electrophoresis chambers of square or rectangular cross-section.
Inventors
- 👤 James M. Van Alstine
- 👤 J. Milton Harris
- 👤 Steve Shafer
- 👤 Robert S. Snyder
- 👤 Blair Herren
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 22:50
CPC Classifications
B; B01; B01D; B01D57/00; B01D57/02; C; C03; C03C; C03C17/00; C03C17/28; C03C17/32; C08; C08J; C08J7/00; C08J7/04; C08J7/0427; C08J7/056; G; G01; G01N; G01N27/00; G01N27/26; G01N27/416; G01N27/447; G01N27/44704; G01N27/44752; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2991; Y10T428/2993; Y10T428/2995; Y10T428/2998
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
42 words
A method for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising conducting electrophoresis employing an electrophoretic surface coated with a monolayer of covalently bound hydrophilic, neutral polymers, provided that said polymers are not polymerized onto said surface.
Claim 2
Independent Claim
42 words
A method for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising conducting electrophoresis employing an electrophoretic surface coated with a monolayer of covalently bound hydrophilic, neutral polymers, provided that said polymers are not polymerized onto said surface.
Claim 3
Dependent Claim
15 words
A method of claim 1, wherein the electrophoretic surface is the surface of a particle.
Claim 4
Dependent Claim
14 words
A method of claim 1, wherein the electrophoretic surface is an electrophoresis chamber surface.
Claim 5
Dependent Claim
13 words
A method of claim 1, wherein the hydrophilic, neutral polymers are poly(ethylene glycol).
Claim 6
Dependent Claim
22 words
A method of claim 1, wherein the hydrophilic, neutral polymers are poly(vinylalcohol), poly(propylene glycol)-poly(ethylene glycol) copolymers or poly(propylene glycol)-poly(ethylene glycol) co-block polymers.
Claim 7
Dependent Claim
34 words
A method of claim 1, wherein the electrophoretic surface is a surface capable of being activating so that the activated surface can react with an activated hydrophilic, neutral polymer thereby forming a covalent bond.
Claim 8
Dependent Claim
11 words
A method of claim 1, wherein the electrophoretic surface is glass.
Claim 9
Dependent Claim
11 words
A method of claim 1, wherein the electrophoretic surface is Plexiglas.
Claim 10
Dependent Claim
11 words
A method of claim 1, wherein the electrophoretic surface is Delrin.
Claim 11
Dependent Claim
11 words
A method of claim 1, wherein the electrophoretic surface is plastic.
Claim 12
Dependent Claim
40 words
An electrophoretic chamber for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising an electrophoretic surface coated with a monolayer of covalently bound hydrophilic, neutral polymers, provided that said polymers are not polymerized onto said surface.
Claim 13
Dependent Claim
40 words
An electrophoretic chamber for eliminating or controlling electroosmosis and other zeta potential related phenomena in electrophoresis comprising an electrophoretic surface coated with a monolayer of covalently bound hydrophilic, neutral polymers, provided that said polymers are not polymerized onto said surface.
Claim 14
Dependent Claim
14 words
An electrophoretic chamber of claim 11, wherein the hydrophilic, neutral polymers are poly(ethylene glycol).
Claim 15
Dependent Claim
24 words
An electrophoretic chamber of claim 11, wherein the hydrophilic, neutral polymers are poly(vinyl alcohol), poly(propylene glycol)-poly(ethylene glycol) copolymers or poly(propylene glycol)-poly(ethylene glycol) co-block polymers.
Claim 16
Dependent Claim
35 words
An electrophoretic chamber of claim 11, wherein the electrophoretic surface is a surface capable of being activated so that the activated surface can react with an activated hydrophilic, neutrald polymer thereby forming a covalent bond.
Claim 17
Dependent Claim
12 words
An electrophoretic chamber of claim 11, wherein the electrophoretic surface is glass.
Claim 18
Dependent Claim
12 words
An electrophoretic chamber of claim 11, wherein the electrophoretic surface is Plexiglas.
Claim 19
Dependent Claim
12 words
An electrophoretic chamber of claim 11, wherein the electrophoretic surface is Delrin.
Claim 20
Dependent Claim
12 words
An electrophoretic chamber of claim 11, wherein the electrophoretic surface is plastic.
Claim 21
Dependent Claim
29 words
A particle exhibiting controlled electrophoretic mobility comprising a surface coated with a monolayer of covalently bound hydrophilic, neutral polymers, provided that said polymers are not polymerized onto said surface.
Claim 22
Dependent Claim
29 words
A particle exhibiting controlled electrophoretic mobility comprising a surface coated with a monolayer of covalently bound hydrophilic, neutral polymers, provided that said polymers are not polymerized onto said surface.
Claim 23
Dependent Claim
13 words
A particle of claim 19, wherein the hydrophilic, neutral polymers are poly(ethylene glycol).
Claim 24
Dependent Claim
23 words
A particle of claim 19, wherein the hydrophilic, neutral polymers are poly(vinyl alcohol), poly(propylene glycol)-poly(ethylene glycol) copolymers or poly(propylene glycol)-poly(ethylene glycol) co-block polymers.
Claim 25
Dependent Claim
34 words
A particle of claim 19, wherein the electrophoretic surface is a surface capable of being activated so that the activated surface can react with an activated hydrophilic, neutral polymer thereby forming a covalent bond.
Claim 26
Dependent Claim
11 words
A particle of claim 19, wherein the electrophoretic surface is glass.
Claim 27
Dependent Claim
11 words
A particle of claim 19, wherein the electrophoretic surface is Plexiglas.
Claim 28
Dependent Claim
11 words
A particle of claim 19, wherein the electrophoretic surface is Delrin.
Claim 29
Dependent Claim
11 words
A particle of claim 19, wherein the electrophoretic surface is plastic.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-31 | 1991-03-02 | 1991-09-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-31 | 1995-03-02 | 1995-09-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-31 | 1999-03-02 | 1999-09-01 | $7700.00 | Window Closed / Lapsed |