US4689218A
Expired / Lapsed
US
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Effervescent composition with analgesic activity
Assignee: Zambon Switzerland Ltd
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Filing: 1986-11-06
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Granted: 1987-08-25
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Expires: 2006-11-06
Abstract
Abstract It is described an effervescent composition consisting of: Ibuprofen 9-17% w/w Arginine 17-33% w/w Sodium or potassium bicarbonate 20-35% w/w Sodium bitartrate 25-40% w/w Such composition is useful for pharmaceutical preparations in the form of effervescent tablets or granulates.
Inventors
- 👤 Annibale Gazzaniga
- 👤 Valter Gianesello
- 👤 Federico Stroppolo
- 👤 Luigi Vigano'
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 14:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0007; A61P; A61P25/00; A61P25/04
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
27 words
Pharmaceutical composition with analgesic activity consisting of Ibuprofen 9-17% w/w Arginine 17-33% w/w Sodium or potassium bicarbonate 20-35% w/w Sodium bitartrate 25-40% w/w the whole being 100%.
Claim 2
Dependent Claim
27 words
Pharmaceutical composition with analgesic activity consisting of Ibuprofen 9-17% w/w Arginine 17-33% w/w Sodium or potassium bicarbonate 20-35% w/w Sodium bitartrate 25-40% w/w the whole being 100%.
Claim 3
Dependent Claim
17 words
Pharmaceutical composition according to claim 1 in which the weight ratio between Ibuprofen and arginine is 1:1.9.
Claim 4
Dependent Claim
19 words
Pharmaceutical composition according to claim 1 in which an amount up to 40% of arginine, is substituted by lysine.
Claim 5
Dependent Claim
18 words
A composition according to claim 1 consisting of Ibuprofen 9.59% Arginine 18.47% NaHCO 3 33.57% Sodium bitartrate 38.37%.
Claim 6
Dependent Claim
18 words
A composition according to claim 1 consisting of Ibuprofen 11.87% Arginine 22.84% NaHCO 3 29.67% Sodium bitartrate 35.62%.
Claim 7
Dependent Claim
18 words
A composition according to claim 1 consisting of Ibuprofen 13.47% Arginine 25.92% NaHCO 3 26.94% Sodium bitartrate 33.67%.
Claim 8
Dependent Claim
18 words
A composition according to claim 1 consisting of Ibuprofen 16.88% Arginine 32.49% NaHCO 3 21.09% Sodium bitartrate 29.54%.
Claim 9
Dependent Claim
21 words
A pharmaceutical composition according to claim 3 consisting of Ibuprofen 9.59% Arginine 12.00% Lysine 6.47% NaHCO 3 33.57% Sodium bitartrate 38.37%.
Claim 10
Dependent Claim
21 words
A pharmaceutical composition according to claim 3 consisting of Ibuprofen 11.87% Arginine 19.84% Lysine 3.00% KHCO 3 29.67% Sodium bitartrate 35.62%.
Claim 11
Dependent Claim
19 words
A pharmaceutical preparation in the form of an effervescent tablet or granulate containing a composition according to claim 1.
Claim 12
Dependent Claim
22 words
A pharmaceutical preparation according to claim 10 containing also a sweetener and a flavouring agent and, optionally, a dye and a lubricant.
Claim 13
Dependent Claim
31 words
A pharmaceutical preparation in the form of an effervescent tablet containing an amount of effervescent composition according to claim 1 corresponding to 200 mg or 400 mg of Ibuprofen each tablet.
Claim 14
Dependent Claim
25 words
An effervescent granulate containing an amount of effervescent composition according to claim 1 corresponding to 200 or 400 mg of Ibuprofen each single dose form.
Claim 15
Dependent Claim
36 words
An effervescent tablet according to claim 10 consisting of Ibuprofen 200 mg Arginine 385 mg NaHCO 3 700 mg Sodium bitartrate 800 mg Saccharose 335 mg Lactose 450 mg Sodium saccharin 30 mg Flavour 100 mg.
Claim 16
Dependent Claim
29 words
An effervescent tablet according to claim 10 consisting of Ibuprofen 200 mg Arginine 385 mg NaHCO 3 400 mg Sodium bitartrate 500 mg Aspartame 40 mg Flavour 100 mg.
Claim 17
Dependent Claim
32 words
An effervescent tablet according to claim 10 consisting of Ibuprofen 400 mg Arginine 770 mg NaHCO 3 1000 mg Sodium bitartrate 1200 mg Aspartame 40 mg Flavour 100 mg Colourant 30 mg.
Claim 18
Dependent Claim
29 words
An effervescent tablet according to claim 10 consisting of Ibuprofen 400 mg Arginine 770 mg NaHCO 3 500 mg Sodium Bitartrate 700 mg Aspartame 40 mg Flavour 90 mg.
Claim 19
Dependent Claim
29 words
An effervescent granulate according to claim 10 consisting of Ibuprofen 200 mg Arginine 385 mg NaHCO 3 400 mg Sodium bitartrate 500 mg Aspartame 40 mg Flavour 100 mg.
Claim 20
Dependent Claim
31 words
An effervescent granulate to claim 10 consisting of Ibuprofen 400 mg Arginine 770 mg NaHCO 3 1000 mg Sodium bitartrate 1200 mg Aspartame 40 mg Flavour 100 mg Colourant 30 mg.
Claim 21
Dependent Claim
21 words
A method for producing analgesia consisting of administering to a subject a pharmaceutical preparation containing a composition according to claim 1.
Claim 22
Dependent Claim
18 words
A method for producing analgesia consisting of administering to a subject a pharmaceutical preparation according to claim 10.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-24 | 1991-02-23 | 1991-08-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-24 | 1995-02-23 | 1995-08-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-24 | 1999-02-23 | 1999-08-25 | $7700.00 | Window Closed / Lapsed |