US4687840A
Expired / Lapsed
US
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Hypotensive active peptides
Assignee: Texas Tech University Health Sciences Center
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Filing: 1986-02-11
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Granted: 1987-08-18
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Expires: 2006-02-11
Abstract
Abstract The present invention provides a hypotensive composition comprising a peptide having the structure X-Y, Y-X, or a salt thereof, wherein X is proline or proline-proline and Y is arginine, lysine, arginine-arginine, lysine-lysine, arginine-lysine, or lysine-arginine, together with a pharmaceutically suitable diluent.
Inventors
- 👤 Peter K. T. Pang
- 👤 Thomas E. Tenner, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:36
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0821; C07K5/0823; C07K5/0815; C07K5/10; C07K5/1019; C07K5/1024
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
A hypotensive active peptide having the L-form amino acid sequence: ______________________________________
Pro--Lys; Lys--Arg--Pro;
Pro--Arg--Arg; Arg--Lys--Pro;
Pro--Lys--Lys; Pro--Pro--Arg--Arg;
Pro--Arg--Lys; Pro--Pro--Arg--Lys;
Pro--Lys--Arg; Pro--Pro--Lys--Lys;
Pro--Pro--Arg; Pro--Pro--Lys--Arg;
Pro--Pro--Lys; Arg--Arg--Pro--Pro;
Lys--Pro--Pro; Lys--Lys--Pro--Pro;
Lys--Lys--Pro; Arg--Lys--Pro--Pro; or
Lys--Arg--Pro--Pro,
______________________________________ and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
37 words
A hypotensive active peptide having the L-form amino acid sequence: ______________________________________
Pro--Lys; Lys--Arg--Pro;
Pro--Arg--Arg; Arg--Lys--Pro;
Pro--Lys--Lys; Pro--Pro--Arg--Arg;
Pro--Arg--Lys; Pro--Pro--Arg--Lys;
Pro--Lys--Arg; Pro--Pro--Lys--Lys;
Pro--Pro--Arg; Pro--Pro--Lys--Arg;
Pro--Pro--Lys; Arg--Arg--Pro--Pro;
Lys--Pro--Pro; Lys--Lys--Pro--Pro;
Lys--Lys--Pro; Arg--Lys--Pro--Pro; or
Lys--Arg--Pro--Pro,
______________________________________ and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
20 words
A hypotensive active peptide having the L-form amino acid sequence: Pro-Lys; Pro-Arg-Lys; Lys-Arg-Pro; or Lys-Arg-Pro-Pro, and pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
20 words
A hypotensive active peptide having the L-form amino acid sequence: Pro-Lys; Pro-Arg-Lys; Lys-Arg-Pro; or Lys-Arg-Pro-Pro, and pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
33 words
A hypotensive active peptide having an L-form amino acid sequence: ______________________________________
Pro--Arg--Arg; Pro--Pro--Arg--Arg;
Pro--Lys--Lys; Pro--Pro--Arg--Lys;
Pro--Arg--Lys; Pro--Pro--Lys--Lys;
Pro--Lys--Arg; Pro--Pro--Lys--Arg;
Pro--Pro--Arg; Arg--Arg--Pro--Pro;
Pro--Pro--Lys; Lys--Lys--Pro--Pro;
Arg--Lys--Pro; Arg--Lys--Pro--Pro; or
Lys--Arg--Pro--Pro;
______________________________________ and pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
33 words
A hypotensive active peptide having an L-form amino acid sequence: ______________________________________
Pro--Arg--Arg; Pro--Pro--Arg--Arg;
Pro--Lys--Lys; Pro--Pro--Arg--Lys;
Pro--Arg--Lys; Pro--Pro--Lys--Lys;
Pro--Lys--Arg; Pro--Pro--Lys--Arg;
Pro--Pro--Arg; Arg--Arg--Pro--Pro;
Pro--Pro--Lys; Lys--Lys--Pro--Pro;
Arg--Lys--Pro; Arg--Lys--Pro--Pro; or
Lys--Arg--Pro--Pro;
______________________________________ and pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
22 words
The hypotensive active peptide of claim 3 which has the L-form amino acid sequence: Pro-Arg-Lys or Lys-Arg-Pro-Pro and pharmaceutically acceptable salts thereof.
References Cited (Backward Citations)
No citation records indexed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-17 | 1991-02-16 | 1991-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-17 | 1995-02-16 | 1995-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-17 | 1999-02-16 | 1999-08-18 | $7700.00 | Window Closed / Lapsed |