US4687764A
Expired / Lapsed
US
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Hypotriglyceridemically active polysaccharides
Assignee: Advance Kaihatsu Kenkyujo KK
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Filing: 1984-07-20
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Granted: 1987-08-18
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Expires: 2004-07-20
Abstract
Abstract A hypotriglyceridemically active polysaccharide having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v % solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography) glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristic: neutral polysaccharides (e) Physiological characteristics: capable of reducing the blood triglyceride in mammals. This hypotriglyceridemically active polysaccharide can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypotriglyceridemically active polysaccharide from the cultured cells of the microorganism and/or the supernatant of the culture broth. The present hypotriglyceridemically active polysaccharide can be used as an active ingredient of a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition, which is suitable for oral administration to mammals.
Inventors
- 👤 Yasuo Kawai
- 👤 Kazunaga Yazawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:26
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61P; A61P1/00; A61P1/16; A61P3/00; A61P3/06; A61P3/08; A61P9/00; A61P9/10; A61P9/12; C; C08; C08B; C08B37/00; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/04; C12R; C12R2001/00; C12R2001/01; C12R2001/46
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
55 words
A polysaccharide having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography: glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristics: neutral polysaccharides (e) Physiological characteristics: capable of reducing the blood triglyceride in mammals.
Claim 2
Dependent Claim
55 words
A polysaccharide having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography: glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristics: neutral polysaccharides (e) Physiological characteristics: capable of reducing the blood triglyceride in mammals.
Claim 3
Dependent Claim
22 words
A polysaccharide as claimed in claim 1, wherein the hypotriglyceridemically active polysaccharide is derived from a microorganism belonging to the genus Streptococcus.
Claim 4
Dependent Claim
38 words
A polysaccharide as claimed in claim 2, wherein said microorganism is at least one member selected from the group consisting of S. faecium, S. faecalis, S. avium, S. bovis, S. salivarius, S. durans, S. mitis, and S. equinus.
Claim 5
Dependent Claim
50 words
A polysaccharide as claimed in claim 2, wherein said microorganism is at least one member selected from the group consisting of S. faecium FERM BP-296, S. faecalis FERM BP-297, S. avium FERM BP-298, S. salivarius FERM BP-299, S. durans FERM BP-300, S. mitis FERM BP-301, and S. equinus FERM BP-302.
Claim 6
Dependent Claim
73 words
A pharmaceutical composition comprising (A) a preventively or therapeutically effective amount of a hypotriglyceridemically active polysaccharide capable of reducing the blood triglyceride in mammals having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography) glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristics: neutral polysaccharides, and (B) a pharmaceutically acceptable carrier therefor.
Claim 7
Dependent Claim
73 words
A pharmaceutical composition comprising (A) a preventively or therapeutically effective amount of a hypotriglyceridemically active polysaccharide capable of reducing the blood triglyceride in mammals having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography) glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristics: neutral polysaccharides, and (B) a pharmaceutically acceptable carrier therefor.
Claim 8
Dependent Claim
23 words
A pharmaceutical composition as claimed in claim 5, wherein said hypotriglyceridemically active polysaccharide is derived from a microoganism belonging to the genus Streptococcus.
Claim 9
Dependent Claim
39 words
A pharmaceutical composition as claimed in claim 6, wherein said microorganism is at least one member selected from the group consisting of S. faecium, S. faecalis, S. avium, S. bovis, S. salivarius, S. durans, S. mitis, and S. equinus.
Claim 10
Dependent Claim
51 words
A pharmaceutical composition as claimed in claim 6, wherein said microorganism is at least one strain selected from the group consisting of S. faecium FERM BP-296, S. faecalis FERM BP-297, S. avium FERM BP-298, S. salivarius FERM BP-299, S. durans FERM BP-300, S. mitis FERM BP-301, and S. equinus FERM BP-302.
Claim 11
Independent Claim
73 words
A method for reducing the blood triglyceride in mammals comprising orally administering to the mammals an effective amount of a hypotriglyceridemically active polysaccharide capable of reducing the blood triglyceride in mammals having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography) glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristics: neutral polysaccharides.
Claim 12
Independent Claim
73 words
A method for reducing the blood triglyceride in mammals comprising orally administering to the mammals an effective amount of a hypotriglyceridemically active polysaccharide capable of reducing the blood triglyceride in mammals having the following characteristics: (a) Specific rotatory power: [α] D 29 =+190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000±3,000 (c) Sugar composition (weight percent by gas chromatography) glucose: 70.3 rhamnose: 13.7 uronic acid: 16.0 (d) Acid-base characteristics: neutral polysaccharides.
Claim 13
Dependent Claim
22 words
A method as claimed in claim 9, wherein said hypotriglyceridemically active polysaccharide is derived from a microorganism belonging to the genus Streptococcus.
Claim 14
Dependent Claim
38 words
A method as claimed in claim 10, wherein said microorganism is at least one member selected from the group consisting of S. faecium, S. faecalis, S. avium, S. bovis, S. salivarius, S. durans, S. mitis, and S. equinus.
Claim 15
Dependent Claim
50 words
A method as claimed in claim 10, wherein said microorganism is at least one strain selected from the group consisting of S. faecium FERM BP-296, S. faecalis FERM BP-297, S. avium FERM BP-298, S. salivarius FERM BP-299, S. durans FERM BP-300, S. mitis FERM BP-301, and S. equinus FERM BP-302.
References Cited (Backward Citations)
US4357323A
Cited
US4536496A
Cited
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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