US4687760A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reduced peptides which inhibit gastric secretion, process for their preparation and pharmaceutical compositions in which they are present
Assignee: Sanofi SA
•
Filing: 1985-12-16
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Granted: 1987-08-18
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Expires: 2005-12-16
Abstract
Abstract The invention relates to the peptides of the formula: <IMAGE> (I) <IMAGE> in which: R1 represents hydrogen or a protecting group for the amine group, such as t-butoxycarbonyl, benzyloxycarbonyl or lower alkanoyl groups; X represents beta-alanine glycine or a direct bond between R1 and the amine group; and R2 represents a group chosen from: <IMAGE> corresponding to the side chains of the natural amino acid leucine, methionine and norleucine. These peptides inhibit gastric secretion.
Inventors
- 👤 Jean Martinez
- 👤 Jean-Pierre Bali
- 👤 Richard Magous
- 👤 Bertrand Castro
- 👤 Henri Demarne
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:50
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06104; C07K5/06113; A; A61; A61P; A61P1/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
70 words
A peptide corresponding to the general formula: ##STR26## in which: R 1 represents hydrogen or a protecting group for the amine group; benzyloxycarbonyl X represents beta-alanine, glycine or a direct bond between R 1 and the amine group; and R 2 represents a group chosen from: ##STR27## corresponding to the side chains of the natural amino acids leucine, methionine and norleucine, and also its salts with inorganic or organic bases.
Claim 2
Dependent Claim
70 words
A peptide corresponding to the general formula: ##STR26## in which: R 1 represents hydrogen or a protecting group for the amine group; benzyloxycarbonyl X represents beta-alanine, glycine or a direct bond between R 1 and the amine group; and R 2 represents a group chosen from: ##STR27## corresponding to the side chains of the natural amino acids leucine, methionine and norleucine, and also its salts with inorganic or organic bases.
Claim 3
Dependent Claim
25 words
A peptide as claimed in claim 1, which corresponds to the formula: ##STR28## in which R 2 has the same meaning mentioned in claim 1.
Claim 4
Dependent Claim
16 words
A peptide as claimed in claim 1, wherein X is glycine and R 2 is leucine.
Claim 5
Dependent Claim
10 words
A peptide as claimed in claim 1 which is: ##STR29##
Claim 6
Dependent Claim
10 words
A peptide as claimed in claim 1 which is: ##STR30##
Claim 7
Dependent Claim
10 words
A peptide as claimed in claim 1 which is: ##STR31##
Claim 8
Dependent Claim
10 words
A peptide as claimed in claim 1 which is: ##STR32##
Claim 9
Dependent Claim
21 words
A peptide as claimed in claim 1 wherein R 1 is a protecting group which is t-butoxycarbonyl, benzyloxycarbonyl or lower alkanoyl.
Claim 10
Dependent Claim
34 words
A pharmaceutical composition for inhibiting gastric secretion which contains, as active ingredient, an effective amount for inhibiting gastric secretion of a peptide as claimed in claim 1 in association with a pharmaceutically acceptable vehicle.
Claim 11
Dependent Claim
34 words
A pharmaceutical composition for inhibiting gastric secretion which contains, as active ingredient, an effective amount for inhibiting gastric secretion of a peptide as claimed in claim 2 in association with a pharmaceutically acceptable vehicle.
Claim 12
Dependent Claim
34 words
A pharmaceutical composition for inhibiting gastric secretion which contains, as active ingredient, an effective amount for inhibiting gastric secretion of a peptide as claimed in claim 3 in association with a pharmaceutically acceptable vehicle.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-17 | 1991-02-16 | 1991-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-17 | 1995-02-16 | 1995-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-17 | 1999-02-16 | 1999-08-18 | $7700.00 | Window Closed / Lapsed |