US4686367A
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Method of operating quadrupole ion trap chemical ionization mass spectrometry
Assignee: Thermo Finnigan LLC
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Filing: 1985-09-06
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Granted: 1987-08-11
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Expires: 2005-09-06
Abstract
Abstract The method of performing chemical ionization and mass analysis with a quadrupole ion trap.
Inventors
- 👤 John N. Louris
- 👤 John E. P. Syka
- 👤 Paul E. Kelley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:20
CPC Classifications
H; H01; H01J; H01J49/00; H01J49/26; H01J49/34; H01J49/42; H01J49/4205; H01J49/424; H01J49/004; H01J49/0081; H01J49/02; H01J49/10; H01J49/14; H01J49/145; H01J49/426; H01J49/427; H01J49/429
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
102 words
The method of mass analyzing a sample (analyte) in a quadrupole ion trap in a chemical ionization (CI) mode which comprises the steps of introducing analyte and reagent molecules into the ion trap having a three dimensional quadrupole field in which low mass ions are stored, ionizing the mixture whereby low mass reagent ions and low mass analyte ions are trapped, changing the three dimensional field while allowing the reagent ions and analytic molecules to react to form product ions and trap higher mass product ions, scanning the three dimensional field to successively eject the product ions and detecting the product ions.
Claim 2
Independent Claim
102 words
The method of mass analyzing a sample (analyte) in a quadrupole ion trap in a chemical ionization (CI) mode which comprises the steps of introducing analyte and reagent molecules into the ion trap having a three dimensional quadrupole field in which low mass ions are stored, ionizing the mixture whereby low mass reagent ions and low mass analyte ions are trapped, changing the three dimensional field while allowing the reagent ions and analytic molecules to react to form product ions and trap higher mass product ions, scanning the three dimensional field to successively eject the product ions and detecting the product ions.
Claim 3
Dependent Claim
87 words
The method of analyzing a sample in a quadruple ion trap as in claim 1 which includes the additional steps of also analyzing the sample in the electron impact (EI) mode which comprises ionizing the analyte with the reagent molecules present while the three dimensional field is held at a level such that all masses up to and including the molecular weight of the reagent gas are not stored and the analyte ions are stored and scanning the three dimensional field to successively eject the analyte ions.
Claim 4
Dependent Claim
28 words
The method of mass analyzing a sample as in claim 1 wherein the three dimensional field is changed by changing the RF portion of the three dimensional field.
Claim 5
Dependent Claim
28 words
The method of mass analyzing a sample as in claim 2 wherein the three dimensional field is changed by changing the RF portion of the three dimensional field.
Claim 6
Dependent Claim
43 words
The method of mass analyzing as in claim 1 which includes the additional step of selecting the three dimensional field to cause the analyte ions to collide and dissociate and thereafter scanning the three dimensional field to successively eject the analytic dissociated ions.
References Cited (Backward Citations)
US4540884A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-10 | 1991-02-09 | 1991-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-10 | 1995-02-09 | 1995-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-10 | 1999-02-09 | 1999-08-11 | $7700.00 | Window Closed / Lapsed |