US4686222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aralkylaminoethanol heterocyclic compounds
Assignee: Merck Sharp & Dohme (I.A.) Corp
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Filing: 1985-10-03
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Granted: 1987-08-11
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Expires: 2005-10-03
Abstract
Abstract Heterocyclic aminoethanols of the formula Het-CHOH-CH2-NH-aralkyl where het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
Inventors
- 👤 Joseph G. Atkinson
- 👤 John J. Baldwin
- 👤 David E. McClure
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 15:55
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/62; C07D213/63; C07D213/64; C07D213/61; C07D213/72; C07D213/73; C07D213/89; C07D263/00; C07D263/52; C07D263/54; C07D263/58; C07D265/00; C07D265/28; C07D265/34; C07D265/36; C07D405/00; C07D405/02; C07D405/04; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
96 words
A compound of the formula: ##STR53## tautomers, pharmaceutically acceptable salts and individual enantiomers thereof wherein R 1 is H or OH, [Z is O or NH] ##STR54## R is wherein R 3 is ##STR55## wherein: R 4 and R 5 are independently selected from H and C 1 -C 3 alkyl, Y is CH 2 , (CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 or --CH 2 --O-- R 6 is H, OH, OCH 3 , halogen, methylenedioxy or C 1 -C 3 alkyl and n is 1 or 2.
Claim 2
Dependent Claim
96 words
A compound of the formula: ##STR53## tautomers, pharmaceutically acceptable salts and individual enantiomers thereof wherein R 1 is H or OH, [Z is O or NH] ##STR54## R is wherein R 3 is ##STR55## wherein: R 4 and R 5 are independently selected from H and C 1 -C 3 alkyl, Y is CH 2 , (CH 2 ) 2 , (CH 2 ) 3 , (CH 2 ) 4 or --CH 2 --O-- R 6 is H, OH, OCH 3 , halogen, methylenedioxy or C 1 -C 3 alkyl and n is 1 or 2.
Claim 3
Dependent Claim
19 words
A compound of claim 1 formula (a) wherein R 1 is H or (b) where R 1 is h.
Claim 4
Dependent Claim
15 words
The compound of claim 2 wherein R 6 is H, OH or OCH 3 .
Claim 5
Dependent Claim
11 words
The compounds of claim 3 wherein Y is CH 2 O.
Claim 6
Dependent Claim
16 words
The compounds of claim 3 wherein Y is CH 2 or (CH 2 ) 2 .
Claim 7
Dependent Claim
13 words
The compounds of claim 5 wherein Y is (CH 2 ) 2 .
Claim 8
Dependent Claim
24 words
THe compounds of claim 6 wherein R 3 is ##STR56## wherein R 4 , and R 5 , are either CH 3 or H.
Claim 9
Dependent Claim
10 words
The compounds of claim 7 wherein R 4 is H.
Claim 10
Dependent Claim
10 words
The compounds of claim 7 wherein R 3 is ##STR57##
Claim 11
Dependent Claim
14 words
A compound of claim 1 formula (a) or (b) where R 1 is OH.
Claim 12
Dependent Claim
12 words
A pharmaceutical composition for effecting bronchoidilation containing a comound of claim 1.
Claim 13
Dependent Claim
20 words
A method for effecting bronchodilation by administering an effective amount of a claim 1 compound in a suitable dosage form.
Claim 14
Dependent Claim
27 words
A method for effecting α-and β-adrenergic blocking activity comprising administering an effective α-and β-adrenergic blocking amount of the compound of claim 1 in a suitable dosage form.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-10 | 1991-02-09 | 1991-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-10 | 1995-02-09 | 1995-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-10 | 1999-02-09 | 1999-08-11 | $7700.00 | Window Closed / Lapsed |