US4684666A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stabilized liquid analgesic compositions
Assignee: ORATECH PHARMACEUTICAL DEVELOPMENT LP
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Filing: 1986-08-19
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Granted: 1987-08-04
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Expires: 2006-08-19
Abstract
Abstract A stabilized liquid ibuprofen syrup suitable for oral administration comprising: from 50 to 400 mg of ibuprofen per 5 ml of syrup; said ibuprofen suspended in an aqueous liquid having more than 50% by weight of a pharmaceutically acceptable polyhydric alcohol bodying agent; a sweetening agent; and a pH of higher than 7.0 and below 7.7.
Inventors
- 👤 Robert T. Haas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 20:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0095; A61K31/00; A61K31/185; A61K31/19; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
107 words
A stabilized ibuprofen-containing syrup containing from 50 to 400 mg of ibuprofen per 5 ml of syrup and comprising: a therapeutically effective amount of ibuprofen or a pharmaceutically acceptable salt or ester thereof; from 50 to 75% by weight of a water compatible bodying agent; less than 1% by weight of a stabilizer adapted to form a particulate or molecular film about the ibuprofen particles; an alkalinizing agent in an amount suitable to provide a final composition of alkaline pH of from above 7.0 to 7.7; sufficient sweetening agent to render the syrup sweet; and from about 0.10 to 0.25% by weight of a pharmaceutically acceptable antioxidant.
Claim 2
Dependent Claim
107 words
A stabilized ibuprofen-containing syrup containing from 50 to 400 mg of ibuprofen per 5 ml of syrup and comprising: a therapeutically effective amount of ibuprofen or a pharmaceutically acceptable salt or ester thereof; from 50 to 75% by weight of a water compatible bodying agent; less than 1% by weight of a stabilizer adapted to form a particulate or molecular film about the ibuprofen particles; an alkalinizing agent in an amount suitable to provide a final composition of alkaline pH of from above 7.0 to 7.7; sufficient sweetening agent to render the syrup sweet; and from about 0.10 to 0.25% by weight of a pharmaceutically acceptable antioxidant.
Claim 3
Dependent Claim
21 words
The stabilized ibuprofen liquid formulation of claim 1 wherein the pH of the final composition is between 7.3 and 7.5 inclusive.
Claim 4
Dependent Claim
17 words
The stabilized ibuprofen liquid formulation of claim 2 wherein said sweetening agent is extrafine, no floc sugar.
Claim 5
Dependent Claim
15 words
The stabilized ibuprofen liquid formulation of claim 1 wherein said sweetening agent is sodium saccharin.
Claim 6
Dependent Claim
18 words
The stabilized ibuprofen liquid formulation of claim 1 wherein said bodying agent is a polyhydric alcohol bodying agent.
Claim 7
Dependent Claim
87 words
A stabilized liquid ibuprofen syrup containing from 50 to 400 mg of ibuprofen per 5 ml of syrup comprising: from 40 to 50 weight percent of sorbitol; from 0.05 to 0.25 weight percent of polyvinylpyrrolidone; from 0.15 to 0.5 weight percent colloidal clay; sodium saccharine in an amount to render the syrup sweet; from 0.1 to 0.25 weight percent sodium metabisulfite; and a therapeutically effective amount of ibuprofen or a pharmaceutically acceptable salt or ester thereof, said syrup having a pH of from 7.3 to 7.5, inclusive.
Claim 8
Dependent Claim
87 words
A stabilized liquid ibuprofen syrup containing from 50 to 400 mg of ibuprofen per 5 ml of syrup comprising: from 40 to 50 weight percent of sorbitol; from 0.05 to 0.25 weight percent of polyvinylpyrrolidone; from 0.15 to 0.5 weight percent colloidal clay; sodium saccharine in an amount to render the syrup sweet; from 0.1 to 0.25 weight percent sodium metabisulfite; and a therapeutically effective amount of ibuprofen or a pharmaceutically acceptable salt or ester thereof, said syrup having a pH of from 7.3 to 7.5, inclusive.
Claim 9
Dependent Claim
54 words
A stabilized liquid ibuprofen syrup suitable for oral administration comprising: from 50 to 400 mg of ibuprofen per 5 ml of syrup; said ibuprofen suspended in an aqueous liquid having more than 50% by weight of a pharmaceutically acceptable polyhydric alcohol bodying agent; a sweetening agent; and a pH of from 7.0 to 7.7.
Claim 10
Dependent Claim
54 words
A stabilized liquid ibuprofen syrup suitable for oral administration comprising: from 50 to 400 mg of ibuprofen per 5 ml of syrup; said ibuprofen suspended in an aqueous liquid having more than 50% by weight of a pharmaceutically acceptable polyhydric alcohol bodying agent; a sweetening agent; and a pH of from 7.0 to 7.7.
Claim 11
Dependent Claim
16 words
The stabilized liquid ibuprofen syrup of claim 7 wherein said pH is 7.3 to 7.5 inclusive.
Claim 12
Dependent Claim
17 words
The syrup of claim 1 wherein the viscosity is about 1000 to 3000 centipoise at 20° C.
Claim 13
Dependent Claim
17 words
The syrup of claim 6 wherein the viscosity is about 1000 to 3000 centipoise at 20° C.
Claim 14
Dependent Claim
17 words
The syrup of claim 7 wherein the viscosity is about 100 to 3000 centipoise at 20° C.
References Cited (Backward Citations)
US3385886A
Cited
US4447451A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-03 | 1991-02-02 | 1991-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-03 | 1995-02-02 | 1995-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-03 | 1999-02-02 | 1999-08-04 | $7700.00 | Window Closed / Lapsed |