US4683209A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Viability test device
Assignee: Bayer Corp
•
Filing: 1986-07-21
•
Granted: 1987-07-28
•
Expires: 2006-07-21
Abstract
Abstract A viability test device wherein the viability of a test composition for the determination of an analyte of interest can be determined by simply wetting the device with ordinary water. The viability device can be prepared in three formats: a control or calibrator device, an internal control device and a self indicating device. Unreacted analyte, or an analog thereof, can be incorporated in a limited defined portion of a dried carrier matrix incorporated with a test composition to provide an internal control test device. When wetted with water, a positive optical response, usually color, indicates the test composition can provide a viable test for the analyte. The internal control test device is particularly advantageously used by diabetics in their own homes where a negative test response could be due to the desired control of the user's condition or due to deterioration of a test composition because of unfavorable storage conditions.
Inventors
- 👤 Ibrahim A. Ismail
- 👤 Paul Hemmes
- 👤 Mark T. Skarstedt
- 👤 Adam Zipp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 00:05
CPC Classifications
G; G01; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/78; G01N21/81; C; C12; C12Q; C12Q1/00; C12Q1/54; G01N33/00; G01N33/48; G01N33/50; G01N33/52; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104998
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
109 words
A method for preparing a viability test device, comprising the sequential steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating at least a portion of the dried carrier matrix with a solution of unreacted analyte, or analog thereof, in a dried non-aqueous solvent at a analyte concentration sufficient to provide a detectable optical response in the doubly incorporated carrier matrix upon wetting of the matrix with water; and (d) drying.
Claim 2
Independent Claim
109 words
A method for preparing a viability test device, comprising the sequential steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating at least a portion of the dried carrier matrix with a solution of unreacted analyte, or analog thereof, in a dried non-aqueous solvent at a analyte concentration sufficient to provide a detectable optical response in the doubly incorporated carrier matrix upon wetting of the matrix with water; and (d) drying.
Claim 3
Independent Claim
89 words
A method for preparing a viability test device, comprising the sequential steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating at least a portion of the dried carrier matrix with a suspension of finely divided particles of unreacted analyte, or analog thereof, in a dried non-aqueous solvent; and (d) drying.
Claim 4
Independent Claim
89 words
A method for preparing a viability test device, comprising the sequential steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating at least a portion of the dried carrier matrix with a suspension of finely divided particles of unreacted analyte, or analog thereof, in a dried non-aqueous solvent; and (d) drying.
Claim 5
Independent Claim
109 words
A method for preparing an internal control test device comprising the steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating a limited defined portion of the dried carrier matrix with a solution of unreacted analyte, or analog thereof, in a dried non-aqueous solvent at an analyte concentration sufficient to provide a detectable optical response in the doubly incorporated carrier matrix upon wetting of the matrix with water; and (d) drying.
Claim 6
Independent Claim
109 words
A method for preparing an internal control test device comprising the steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating a limited defined portion of the dried carrier matrix with a solution of unreacted analyte, or analog thereof, in a dried non-aqueous solvent at an analyte concentration sufficient to provide a detectable optical response in the doubly incorporated carrier matrix upon wetting of the matrix with water; and (d) drying.
Claim 7
Dependent Claim
52 words
The method of claim 3 in which the incorporated analyte is chosen from a mixture of α-and β-D-glucose, β-D-glucose or an analog of D-glucose, and which dried nonaqueous solvent used is capable of dissolving and maintaining D-glucose in the β form or capable of supporting mutarotation of D-glucose to the β form.
Claim 8
Dependent Claim
17 words
The method of claim 4 in which the solvent is chosen from dimethylformamide, pyridine, 2-methoxyethanol and methoxy-2-propanol.
Claim 9
Independent Claim
112 words
A method for preparing internal control test device comprising the steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition, which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating a limited defined portion of the dried carrier matrix with a suspension of finely divided particles of unreacted analyte, or analog thereof, in a dried nonaqueous solvent at an analyte concentration sufficient to provide a detectable optical response in the doubly incorporated carrier matrix upon wetting of the matrix with water; and (d) drying.
Claim 10
Independent Claim
112 words
A method for preparing internal control test device comprising the steps of: (a) incorporating a carrier matrix substantially uniformly with a test composition, which test composition is capable of providing a detectable optical response upon wetting of the test composition incorporated carrier matrix with water in the presence of the analyte to be determined; (b) drying; (c) incorporating a limited defined portion of the dried carrier matrix with a suspension of finely divided particles of unreacted analyte, or analog thereof, in a dried nonaqueous solvent at an analyte concentration sufficient to provide a detectable optical response in the doubly incorporated carrier matrix upon wetting of the matrix with water; and (d) drying.
References Cited (Backward Citations)
US4193766A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-27 | 1991-01-26 | 1991-07-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-27 | 1995-01-26 | 1995-07-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-27 | 1999-01-26 | 1999-07-28 | $7700.00 | Window Closed / Lapsed |