US4682035A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solid state counting system for high energy beta and gamma decay isotopes
Assignee: BIOSCAN Inc
•
Filing: 1985-04-23
•
Granted: 1987-07-21
•
Expires: 2005-04-23
Abstract
Abstract The disclosure relates to a method and apparatus for quantitatively evaluating radiation emissions of radiolabeled laboratory samples. These radiation emissions frequently include high energy beta and gamma radiation emissions resulting from 32 P isotope decay. High energy beta and gamma radiation is detected by a solid state PIN photodiode and analyzed by a microprocessor to provide an indication of a radiation emission characteristic such as activity expressed in disintegrations per minute (DPM). An indication of sample activity is obtained from a detected sample count rate adjusted by a detector calibration constant which is determined by the microprocessor from a reference radiation emitting sample of known activity and volume. Indications of radiation emission characteristics may be displayed by an alpha-numeric liquid crystal display. Hard copy data may be produced from an expansion module in the form of a printer module adapted to receive data input from the microprocessor. Another expansion module, a high performance liquid chromatography (HPLC) flow detector, provides indications of radiation emissions of a sample flow passing through the flow detector. Radiation emission characteristics obtained from the sample flow may be printed by the printer module or displayed by the alpha-numeric liquid crystal display.
Inventors
- 👤 Seth D. Shulman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 06:46
CPC Classifications
G; G01; G01T; G01T7/00; G01T1/00; G01T1/16; G01T1/20; G01T1/204
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
142 words
A portable, bench top radiation detection apparatus for quantitative analysis of radioactive samples comprising: a sample holder having an opening defining an interior sample receiving zone for receiving a container containing a single radiation-emitting sample; a generally planar, solid state radiation detector positioned adjacent said sample holder at one end of the sample receiving zone for detecting radiation emitted by said radiation-emitting sample; signal analyzing means responsive to said radiation detector for quantitatively analyzing radiation emitted by said radiation-emitting sample, said signal analyzing means including means for storing a value related to a pre-selected radiation emissing characteristic of a known radiation-emitting sample positioned in said sample receiving zone, and means responsive to said stored value for analyzing radiation emissions from a different sample placed in said sample receiving zone; and means for displaying a radiation emission characteristic for said different radiation-emitting sample.
Claim 2
Dependent Claim
142 words
A portable, bench top radiation detection apparatus for quantitative analysis of radioactive samples comprising: a sample holder having an opening defining an interior sample receiving zone for receiving a container containing a single radiation-emitting sample; a generally planar, solid state radiation detector positioned adjacent said sample holder at one end of the sample receiving zone for detecting radiation emitted by said radiation-emitting sample; signal analyzing means responsive to said radiation detector for quantitatively analyzing radiation emitted by said radiation-emitting sample, said signal analyzing means including means for storing a value related to a pre-selected radiation emissing characteristic of a known radiation-emitting sample positioned in said sample receiving zone, and means responsive to said stored value for analyzing radiation emissions from a different sample placed in said sample receiving zone; and means for displaying a radiation emission characteristic for said different radiation-emitting sample.
Claim 3
Dependent Claim
24 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said radiation detector is a solid state diode.
Claim 4
Dependent Claim
25 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 2, wherein said radiation detector is a solid state PIN photodiode.
Claim 5
Dependent Claim
32 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said sample container cooperates with said sample holder to provide an essentially fixed sample-detector spatial relationship.
Claim 6
Dependent Claim
48 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said apparatus includes connection means providing communication with at least one expansion module comprising an additional circuit board and electrical and mechanical parts for altering the functional capability of said radiation detector.
Claim 7
Dependent Claim
33 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 5, wherein said at least one expansion module includes means for communicating with at least one other expansion module.
Claim 8
Dependent Claim
25 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said means for displaying is a digital display means.
Claim 9
Dependent Claim
26 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said means for displaying is an alpha-numeric liquid crystal display.
Claim 10
Dependent Claim
25 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said signal analyzing means includes a data input keyboard.
Claim 11
Dependent Claim
37 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said pre-selected radiation emission characteristic represents a radiation activity value expressed in disintegrations per minute (DPM) for said known radiation-emitting sample.
Claim 12
Dependent Claim
62 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said pre-selected radiation emission characteristic represents a calibration factor C relating a known radiation emission characteristic measured in disintegrations per minute (DPM) to a detected radiation emission characteristic expressed in counts per minute (CPM) for said known radiation emitting sample in accordance with the expression: DPM=C×CPM.
Claim 13
Dependent Claim
29 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said radiation detector is responsive to high energy beta and gamma radiation emissions.
Claim 14
Dependent Claim
27 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 1, wherein said radiation detector is responsive to 32 P isotope decay emissions.
Claim 15
Independent Claim
152 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus comprising the steps of: inserting a first container containing a known radiation-emitting sample into a sample receiving zone of a radiation detection apparatus; detecting radiation emitted by said known radiation-emitting sample into said sample receiving zone with generally planar detector and generating a signal responsive to said detected radiation; quantitatively analyzing said detected radiation with respect to a pre-selected radiation emission characteristic stored in a memory means; removing said first container and inserting into said sample receiving zone a second container containing a second radiation-emitting sample; detecting radiation emitted by said second radiation-emitting sample into said sample receiving zone and generating a second signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said second radiation-emitting sample with respect to said preselected radiation emission characteristic; and displaying a radiation emission characteristic for said second sample.
Claim 16
Independent Claim
152 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus comprising the steps of: inserting a first container containing a known radiation-emitting sample into a sample receiving zone of a radiation detection apparatus; detecting radiation emitted by said known radiation-emitting sample into said sample receiving zone with generally planar detector and generating a signal responsive to said detected radiation; quantitatively analyzing said detected radiation with respect to a pre-selected radiation emission characteristic stored in a memory means; removing said first container and inserting into said sample receiving zone a second container containing a second radiation-emitting sample; detecting radiation emitted by said second radiation-emitting sample into said sample receiving zone and generating a second signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said second radiation-emitting sample with respect to said preselected radiation emission characteristic; and displaying a radiation emission characteristic for said second sample.
Claim 17
Dependent Claim
45 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein each of said first and second containers is positioned relative to said planar detector of radiation so as to obtain an essentially fixed sample-detector spatial relationship.
Claim 18
Dependent Claim
28 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 15, wherein said radiation detector is a solid state diode detector.
Claim 19
Dependent Claim
28 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 15, wherein said radiation detector is a solid state PIN photodiode.
Claim 20
Dependent Claim
29 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein said detected radiation comprises high energy beta and gamma radiation.
Claim 21
Dependent Claim
27 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein said detected radiation comprises 32 P isotope emissions.
Claim 22
Dependent Claim
35 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein said pre-selected radiation emission characteristic is communicated to said memory means by a data input keyboard.
Claim 23
Dependent Claim
41 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein said pre-selected radiation emission characteristic is an indication of activity of said known radiation emitting sample expressed in disintegrations per minute (DPM).
Claim 24
Dependent Claim
68 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein one of said at least one preselected radiation emission characteristics is a calibration constant C relating a known radiation emission characteristic expressed in disintegrations per minute (DPM) to a detected radiation emission characteristic expressed in counts per minute (CPM) for said known sample in accordance with the expression DPM=C×CPM.
Claim 25
Dependent Claim
32 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 14, wherein an alpha-numeric liquid crystal display is used for displaying said radiation emission characteristic.
Claim 26
Independent Claim
186 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus comprising the steps of: inserting a first container containing a known radiation-emitting sample into a sample receiving zone of a radiation detection apparatus to position said first container relative to a planar detector of radiation so as to obtain an essentially fixed sample-detector spatial relationship; detecting radiation emitted by said known radiation-emitting sample and generating a signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said known radiation-emitting sample with respect to at least one preselected radiation emisson characteristic stored in a memory means; removing said first container and inserting into said sample receiving zone a second container containing a second radiation-emitting sample and positioning said second container so as to obtain the essentially fixed sample-detector spatial relationship; detecting radiation emitted by said second radiation-emitting sample and generating a second signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said second radiation-emitting sample with respect to said at least one pre-selected radiation emission characteristic; and displaying a radiation emission characteristic for said second radiation-emitting sample.
Claim 27
Independent Claim
186 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus comprising the steps of: inserting a first container containing a known radiation-emitting sample into a sample receiving zone of a radiation detection apparatus to position said first container relative to a planar detector of radiation so as to obtain an essentially fixed sample-detector spatial relationship; detecting radiation emitted by said known radiation-emitting sample and generating a signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said known radiation-emitting sample with respect to at least one preselected radiation emisson characteristic stored in a memory means; removing said first container and inserting into said sample receiving zone a second container containing a second radiation-emitting sample and positioning said second container so as to obtain the essentially fixed sample-detector spatial relationship; detecting radiation emitted by said second radiation-emitting sample and generating a second signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said second radiation-emitting sample with respect to said at least one pre-selected radiation emission characteristic; and displaying a radiation emission characteristic for said second radiation-emitting sample.
Claim 28
Dependent Claim
29 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 24, wherein said detected radiation comprises high energy beta and gamma radiation.
Claim 29
Dependent Claim
29 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 24, wherein said detector of radiation is a solid state diode detector.
Claim 30
Dependent Claim
35 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 24, wherein said pre-selected radiation emission characteristic is communicated to said memory means by a data input keyboard.
Claim 31
Dependent Claim
63 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 24, wherein one of said pre-selected radiation emission characteristics is a calibration constant C relating a known radiation emission characteristic expressed in disintegrations per minute (DPM) to a detected measurement expressed in counts per minute (CPM) for said known sample in accordance with he expression: DPM=C×CPM.
Claim 32
Dependent Claim
156 words
A portable, bench top radiation detection apparatus for quantitative analysis of radiation-emitting samples comprising: a sample holder having an opening defining an interior sample receiving zone for receiving a container containing a single radiation-emitting sample; a generally planar radiation detector positioned adjacent said sample holder along only a portion of said sample receiving zone for detecting radiation emitted by said radiation-emitting sample; signal analyzing means responsive to said radiation detector for quantitatively analyzing radiation emitted by said radiation-emitting sample, said signal analyzing means including means for storing a value related to a pre-selected radiation emission characteristic of a known radiation-emitting sample positioned in said sample receiving zone in an essentially fixed sample-detector spatial relationship, and means responsive to said stored value for analyzing radiation emissions from a different radiation-emitting sample placed in said sample receiving zone in said essentially fixed sample-detector spatial relationship; and means for displaying a radiation emission characteristic for said different radiation-emitting sample.
Claim 33
Dependent Claim
156 words
A portable, bench top radiation detection apparatus for quantitative analysis of radiation-emitting samples comprising: a sample holder having an opening defining an interior sample receiving zone for receiving a container containing a single radiation-emitting sample; a generally planar radiation detector positioned adjacent said sample holder along only a portion of said sample receiving zone for detecting radiation emitted by said radiation-emitting sample; signal analyzing means responsive to said radiation detector for quantitatively analyzing radiation emitted by said radiation-emitting sample, said signal analyzing means including means for storing a value related to a pre-selected radiation emission characteristic of a known radiation-emitting sample positioned in said sample receiving zone in an essentially fixed sample-detector spatial relationship, and means responsive to said stored value for analyzing radiation emissions from a different radiation-emitting sample placed in said sample receiving zone in said essentially fixed sample-detector spatial relationship; and means for displaying a radiation emission characteristic for said different radiation-emitting sample.
Claim 34
Dependent Claim
24 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 29, wherein said radiation detector is a solid state diode.
Claim 35
Dependent Claim
29 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 29, wherein said apparatus includes connection means providing communication with at least one expansion module.
Claim 36
Dependent Claim
26 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 29, wherein said means for displaying is an alpha-numeric liquid crystal display.
Claim 37
Dependent Claim
25 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 32, wherein said signal analyzing means includes a data input keyboard.
Claim 38
Dependent Claim
59 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 33, wherein said stored value is a calibration factor C relating a known radiation emission characteristic expressed in disintegrations per minute (DPM) to a detected radiation emission characteristic expressed in counts per minute (CPM) for said known radiation-emitting sample in accordance with the expression: DPM=C×CPM.
Claim 39
Dependent Claim
141 words
A portable, bench top radiation detection apparatus for quantitative analysis of radioactive samples comprising: a sample holder having an interior, generally cylindrical sample receiving zone for receiving a a single radiation-emitting sample which is not specially processed for use with said radiation detection apparatus; a generally planar radiation detector positioned adjacent said sample holder for detecting radiation emitted by said radiation-emitting sample; signal analyzing means responsive to said radiation detector for quantitatively analyzing radiation emitted by said radiation-emitting sample, said signal analyzing means including means for storing a value related to a pre-selected radiation emission characteristic of a known radiation-emitting sample positioned in said sample receiving zone, and means responsive to said stored value for analyzing radiation emissions from a different sample placed in said sample receiving zone; and means for displaying a radiation emission characteristic for said different radiation-emitting sample.
Claim 40
Dependent Claim
141 words
A portable, bench top radiation detection apparatus for quantitative analysis of radioactive samples comprising: a sample holder having an interior, generally cylindrical sample receiving zone for receiving a a single radiation-emitting sample which is not specially processed for use with said radiation detection apparatus; a generally planar radiation detector positioned adjacent said sample holder for detecting radiation emitted by said radiation-emitting sample; signal analyzing means responsive to said radiation detector for quantitatively analyzing radiation emitted by said radiation-emitting sample, said signal analyzing means including means for storing a value related to a pre-selected radiation emission characteristic of a known radiation-emitting sample positioned in said sample receiving zone, and means responsive to said stored value for analyzing radiation emissions from a different sample placed in said sample receiving zone; and means for displaying a radiation emission characteristic for said different radiation-emitting sample.
Claim 41
Dependent Claim
24 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 35, wherein said radiation detector is a solid state diode.
Claim 42
Dependent Claim
33 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 36, wherein said sample container cooperates with said sample receiving zone to provide an essentially fixed sample-detector spatial relationship.
Claim 43
Dependent Claim
25 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 37, wherein said means for displaying is a digital display means.
Claim 44
Dependent Claim
25 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 38, wherein said signal analyzing means includes a data input keyboard.
Claim 45
Dependent Claim
62 words
The portable, bench top radiation detector for quantitative analysis of radiation-emitting samples of claim 37, wherein said pre-selected radiation emission characteristic represents a calibration factor C relating a known radiation emission characteristic measured in disintegrations per minute (DPM) to a detected radiation emission characteristic expressed in counts per minute (CPM) for said known radiation emitting sample in accordance with the expression: DPM=C×CPM.
Claim 46
Independent Claim
165 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus comprising the steps of: inserting a first container containing a known radiation-emitting sample into a sample receiving zone of a radiation detection apparatus; detecting radiation emitted by said known radiation-emitting sample into said sample receiving zone with a generally planar detector and generating a signal responsive to said detected radiation; quantitatively analyzing said detected radiation with respect to a pre-selected radiation emission characteristic stored in a memory means; removing said first container and inserting into said sample receiving zone a second container containing a second radiation-emitting sample, which second sample is not specially processed for use with said method; detecting radiation emitted by said second radiation-emitting sample into said sample receiving zone and generating a second signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said second radiation-emitting sample with respect to said preselected radiation emission characteristic; and displaying a radiation emission characteristic for said second sample.
Claim 47
Independent Claim
165 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus comprising the steps of: inserting a first container containing a known radiation-emitting sample into a sample receiving zone of a radiation detection apparatus; detecting radiation emitted by said known radiation-emitting sample into said sample receiving zone with a generally planar detector and generating a signal responsive to said detected radiation; quantitatively analyzing said detected radiation with respect to a pre-selected radiation emission characteristic stored in a memory means; removing said first container and inserting into said sample receiving zone a second container containing a second radiation-emitting sample, which second sample is not specially processed for use with said method; detecting radiation emitted by said second radiation-emitting sample into said sample receiving zone and generating a second signal responsive to said detected radiation; quantitatively analyzing said radiation emitted by said second radiation-emitting sample with respect to said preselected radiation emission characteristic; and displaying a radiation emission characteristic for said second sample.
Claim 48
Dependent Claim
45 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 41, wherein each of said first and second containers is positioned relative to said planar detector of radiation so as to obtain an essentially fixed sample-detector spatial relationship.
Claim 49
Dependent Claim
29 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 41, wherein said detected radiation comprises high energy beta and gamma radiation.
Claim 50
Dependent Claim
29 words
A method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 41, wherein said radiation detector is a planar solid state diode detector.
Claim 51
Dependent Claim
35 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 44, wherein said pre-selected radiation emission characteristic is communicated to said memory means by a data input keyboard.
Claim 52
Dependent Claim
68 words
The method for quantitatively analyzing radiation-emitting samples in a portable, bench top radiation detection apparatus of claim 41, wherein one of said at least one preselected radiation emission characteristics is a calibration constant C relating a known radiation emission characteristic expressed in disintegrations per minute (DPM) to a detected radiation emission characteristic expressed in counts per minute (CPM) for said known sample in accordance with the expression DPM=C×CPM.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-20 | 1991-01-19 | 1991-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-20 | 1995-01-19 | 1995-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-20 | 1999-01-19 | 1999-07-21 | $7700.00 | Window Closed / Lapsed |