US4679561A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable apparatus for localized heating of tissue
Assignee: United States Department of Energy
•
Filing: 1985-05-20
•
Granted: 1987-07-14
•
Expires: 2005-05-20
Abstract
Abstract With the object of repetitively treating deep-seated, inoperable tumors by hyperthermia as well as locally heating other internal tissue masses repetitively, a receiving antenna, transmission line, and electrode arrangment are implanted completely within the patient's body, with the receiving antenna just under the surface of the skin and with the electrode arrangement being located so as to most effectively heat the tissue to be treated. An external, transmitting antenna, driven by an external radio-frequency energy source, is closely coupled to the implanted receiving antenna so that the energy coupled across the air-skin interface provides electromagnetic energy suitable for heating the tissue in the vicinity of the implanted electrodes. The resulting increase in tissue temperature may be estimated by an indirect measurement of the decrease in tissue resistivity in the heated region. This change in resistivity appears as a change in the loading of the receiving antenna which can be measured by either determining the change in the phase relationship between the voltage and the current appearing on the transmitting antenna or by measuring the change in the magnitude of the impedance thereof. Optionally, multiple electrode arrays may be activated or inactivated by the application of magnetic fields to operate implanted magnetic reed switches.
Inventors
- 👤 James D. Doss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:23
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/40; A61N1/403
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
320 words
An apparatus for locally increasing the temperature of living tissue located inside of a body, said apparatus comprising in combination: a. means disposed externally to the body for generating radio-frequency electromagnetic energy having a chosen intensity; b. first antenna means for receiving and for radiating the radio-frequency electromagnetic energy from said means for generating radio-frequency electromagnetic energy, said first antenna means being adapted for placement at substantially the closest location external to the body to the tissue to be heated; c. second antenna means closely coupled to said first antenna means for receiving the radiated electromagnetic energy and for generating an alternating voltage therefrom having a first electrical connection and a second electrical connection, said second antenna means being adapted for location within the body near an accessible outer surface thereof in order to facilitate receiving the radiated electromagnetic energy, whereby the alternating voltage appears between said first electrical connection and said second electrical connection; d. at least one first electrode means being in electrical contact with said first electrical connection and at least one second electrode means being in electrical contact with said second electrical connection for receiving the alternating voltage appearing between said first electrical connection and said second electrical connection of said second antenna means, said at least one first electrode means and said at least one second electrode means being adapted for location within the tissue to be heated in the vicinity of at least one of said first electrode means and said second electrode means causing thereby an increase in temperature therein; and e. means for externally measuring the voltage current characteristics of said first antenna means for determining the increase in temperature within the tissue to be heated, said means for externally measuring the voltage current characteristics of said first antenna means having parametric dependence on the change in electrical resistance within the tissue to be heated resulting from the increase in temperature therein.
Claim 2
Independent Claim
320 words
An apparatus for locally increasing the temperature of living tissue located inside of a body, said apparatus comprising in combination: a. means disposed externally to the body for generating radio-frequency electromagnetic energy having a chosen intensity; b. first antenna means for receiving and for radiating the radio-frequency electromagnetic energy from said means for generating radio-frequency electromagnetic energy, said first antenna means being adapted for placement at substantially the closest location external to the body to the tissue to be heated; c. second antenna means closely coupled to said first antenna means for receiving the radiated electromagnetic energy and for generating an alternating voltage therefrom having a first electrical connection and a second electrical connection, said second antenna means being adapted for location within the body near an accessible outer surface thereof in order to facilitate receiving the radiated electromagnetic energy, whereby the alternating voltage appears between said first electrical connection and said second electrical connection; d. at least one first electrode means being in electrical contact with said first electrical connection and at least one second electrode means being in electrical contact with said second electrical connection for receiving the alternating voltage appearing between said first electrical connection and said second electrical connection of said second antenna means, said at least one first electrode means and said at least one second electrode means being adapted for location within the tissue to be heated in the vicinity of at least one of said first electrode means and said second electrode means causing thereby an increase in temperature therein; and e. means for externally measuring the voltage current characteristics of said first antenna means for determining the increase in temperature within the tissue to be heated, said means for externally measuring the voltage current characteristics of said first antenna means having parametric dependence on the change in electrical resistance within the tissue to be heated resulting from the increase in temperature therein.
Claim 3
Dependent Claim
62 words
The apparatus as described in claim 1, wherein said external temperature determining means includes a directional coupler located in between said radio-frequency electromagnetic energy generation means and said first antenna means, said directional coupler having a first output for sampling the output from said radio-frequency electromagnetic energy generation means and a second output for sampling reflected power from said first antenna means.
Claim 4
Dependent Claim
66 words
The apparatus as described in claim 1, wherein said external temperature determining means includes means for measuring the voltage appearing across said first antenna means, means for measuring the current passing through said first antenna means, and means for receiving the voltage and the current so measured and for relating the voltage and current measured thereby to the temperature increase in the tissue to be heated.
Claim 5
Dependent Claim
43 words
The apparatus as described in claim 3, wherein said means for receiving and for relating the voltage and current relates changes in the phase shift between the voltage and the current measured thereby to the temperature increase in the tissue to be heated.
Claim 6
Dependent Claim
40 words
The apparatus as described in claim 3, wherein said means for receiving and for relating the voltage and current relates the ratio of the voltage and the current measured thereby to the temperature increase in the tissue to be heated.
Claim 7
Independent Claim
58 words
The apparatus as described in claims 4 or 5, wherein means are provided for controlling the temperature of the tissue to be heated by adjusting the intensity of said means for generating radio-frequency electromagnetic energy, said temperature controlling means having as its input the output of the means for receiving and for relating the voltage and the current.
References Cited (Backward Citations)
US3796221A
Cited
US4016886A
Cited
US4095602A
Cited
US4154246A
Cited
US4186729A
Cited
US4346715A
Cited
US4448198A
Cited
US4378806A
Cited
US4397314A
Cited
WO1984002839A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-13 | 1991-01-12 | 1991-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-13 | 1995-01-12 | 1995-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-13 | 1999-01-12 | 1999-07-14 | $7700.00 | Window Closed / Lapsed |