US4677113A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Di-t-butylphenols substituted by a thenoyl group
Assignee: Riker Laboratories Inc
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Filing: 1986-04-22
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Granted: 1987-06-30
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Expires: 2006-04-22
Abstract
Abstract Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by a thenoyl group, which thenoyl group is substituted by an acid group are useful as inhibitors of leukotriene synthesis and as antiallergic agents.
Inventors
- 👤 Randy L. Bell
- 👤 George G. I. Moore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 14:20
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38; C07D333/40; A; A61; A61P; A61P11/00; A61P11/08; A61P37/00; A61P37/08; A61P43/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
32 words
A compound of the formula ##STR16## or a derivative thereof selected from a lower alkyl ester, a (lower)alkylamino(lower)alkyl ester, a pharmaceutically acceptable (lower)alkylamino(lower)alkyl ester acid-addition salt and a pharmaceutically acceptable carboxylate salt.
Claim 2
Dependent Claim
32 words
A compound of the formula ##STR16## or a derivative thereof selected from a lower alkyl ester, a (lower)alkylamino(lower)alkyl ester, a pharmaceutically acceptable (lower)alkylamino(lower)alkyl ester acid-addition salt and a pharmaceutically acceptable carboxylate salt.
Claim 3
Dependent Claim
18 words
A compound according to claim 1, wherein the carboxyl is on the 5 position of the thiophene ring.
Claim 4
Dependent Claim
19 words
A compound according to claim 1, wherein the linking carbonyl is on the 2 position of the thiophene ring.
Claim 5
Dependent Claim
6 words
5-(3',5'-di-t-butyl-4'-hydroxybenzoyl)thiophene-2-carboxylic acid according to claim 1.
Claim 6
Dependent Claim
6 words
A compound of the formula ##STR17##
Claim 7
Dependent Claim
6 words
A compound of the formula ##STR17##
Claim 8
Dependent Claim
32 words
A method for inhibiting bronchoconstriction due to an allergic reaction in a mammal comprising administering a compound according to claim 1 to said mammal in an amount effective to inhibit said bronchoconstriction.
Claim 9
Dependent Claim
29 words
An antiallergic pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, said compound being present in an amount sufficient for providing an antiallergic response.
Claim 10
Dependent Claim
28 words
A method for inhibiting leukotriene synthesis in a mammal comprising administering a compound according to claim 1 to said mammal in an amount effective to inhibit said synthesis.
Claim 11
Dependent Claim
28 words
A method for inhibiting lipoxygenase activity in a mammal comprising administering a compound according to claim 1 to said mammal in an amount effective to inhibit said activity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-29 | 1990-12-29 | 1991-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-29 | 1994-12-29 | 1995-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-29 | 1998-12-29 | 1999-06-30 | $7700.00 | Window Closed / Lapsed |