US4677103A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Labdane compounds, pharmaceutical compositions and use
Assignee: Aventis Pharmaceuticals Inc
•
Filing: 1986-10-20
•
Granted: 1987-06-30
•
Expires: 2006-10-20
Abstract
Abstract Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
Inventors
- 👤 Raymond W. Kosley, Jr.
- 👤 Robert J. Cherill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 11:35
CPC Classifications
C; C07; C07D; C07D407/00; C07D407/02; C07D407/12; C07D311/00; C07D311/02; C07D311/78; C07D311/92; C07D493/00; C07D493/02; C07D493/04; C07D493/10; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07F9/00; C07F9/02; C07F9/547; C07F9/655; C07F9/65502
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
159 words
A compound of the formula ##STR16## wherein: (a) R 6 and R 7 taken together form a group of the formula CO or a group of the formula SO; (b) R 1 and R 9 taken together form a group of the formula CHNR 19 R 20 wherein R 19 and R 20 are each independently loweralkyl; and R 19 and R 20 taken together with the nitrogen atom to which they are attached form a group of the formula ##STR17## wherein X is O, S or a group of the formula CHR 15 wherein R 15 is hydrogen, loweralkyl or a group of the formula OR 16 wherein R 16 is hydrogen, loweralkyl or a group of the formula COR 17 wherein R 17 is loweralkyl, and m is 0 or 1; a group of the formula NR 18 wherein R 18 is loweralkyl; the optical and geometric isomers thereof, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
159 words
A compound of the formula ##STR16## wherein: (a) R 6 and R 7 taken together form a group of the formula CO or a group of the formula SO; (b) R 1 and R 9 taken together form a group of the formula CHNR 19 R 20 wherein R 19 and R 20 are each independently loweralkyl; and R 19 and R 20 taken together with the nitrogen atom to which they are attached form a group of the formula ##STR17## wherein X is O, S or a group of the formula CHR 15 wherein R 15 is hydrogen, loweralkyl or a group of the formula OR 16 wherein R 16 is hydrogen, loweralkyl or a group of the formula COR 17 wherein R 17 is loweralkyl, and m is 0 or 1; a group of the formula NR 18 wherein R 18 is loweralkyl; the optical and geometric isomers thereof, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
9 words
The compound of claim 1 which is 8,13-epoxy-1α,9α-dihydroxylabd-14-en-11-one-1α,9α-dimethylformamide acetal-6β,7β-sulfite.
Claim 4
Dependent Claim
12 words
The compound according to claim 1 which is 8,13-epoxy-1α,6β,7β,9α-tetrahydroxylabd-14-en-11-one 6,7-carbonate 1,9-dimethylformamide acetal.
Claim 5
Dependent Claim
38 words
A method of reducing intraocular pressure in mammals comprising administering to a mammal requiring intraocular pressure reduction, an intraocular pressure reducing effective amount of a compound or a pharmaceutically acceptable acid addition salt thereof according to claim 1.
Claim 6
Dependent Claim
38 words
An intraocular pressure reducing composition comprising an inert intraocular pressure reducing adjuvant and as the active ingredient, an intraocular pressure reducing effective amount of a compound or a pharmaceutically acceptable acid addition salt thereof according to claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-29 | 1990-12-29 | 1991-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-29 | 1994-12-29 | 1995-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-29 | 1998-12-29 | 1999-06-30 | $7700.00 | Window Closed / Lapsed |