US4670428A
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Method for treating convulsions and epilepsy with organic copper compounds
Assignee: INTERNATIONAL COPPER RESEARCH ASSOCIATION Inc A CORP OF NY
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Filing: 1984-08-14
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Granted: 1987-06-02
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Expires: 2004-08-14
Abstract
Abstract Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.
Inventors
- 👤 John R. J. Sorenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 07:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/28; A61K31/30
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
65 words
A method of treating convulsive tremors or convulsive seizures comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity selected from the group consisting of copper complexes of hydantoins, copper complexes of barbiturates, copper complexes of thiobarbiturates, copper complexes of desoxybarbiturates, copper complexes of acetylureas, copper complexes of succinimides, copper complexes of oxazolidinediones, and mixtures thereof.
Claim 2
Independent Claim
65 words
A method of treating convulsive tremors or convulsive seizures comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity selected from the group consisting of copper complexes of hydantoins, copper complexes of barbiturates, copper complexes of thiobarbiturates, copper complexes of desoxybarbiturates, copper complexes of acetylureas, copper complexes of succinimides, copper complexes of oxazolidinediones, and mixtures thereof.
Claim 3
Independent Claim
61 words
A method of treating epilepsy comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having antiepileptic activity selected from the group consisting of copper complexes of hydantoins, copper complexes of barbiturates, copper complexes of desoxybarbiturates, copper complexes of thiobarbiturates, copper complexes of acetylureas, copper complexes of succinimides, copper complexes of oxazolidinediones, and mixtures thereof.
Claim 4
Independent Claim
61 words
A method of treating epilepsy comprising administration to a mammal of a therapeutically effective amount of an organic compound of copper having antiepileptic activity selected from the group consisting of copper complexes of hydantoins, copper complexes of barbiturates, copper complexes of desoxybarbiturates, copper complexes of thiobarbiturates, copper complexes of acetylureas, copper complexes of succinimides, copper complexes of oxazolidinediones, and mixtures thereof.
Claim 5
Dependent Claim
106 words
The method according to claim 1 or 2 wherein the organic compound of copper is selected from the group consisting of: (a) Cu(II)(dilantin) 2 (H 2 O) 3 ; (b) Cu(II)(phenobarbital) 2 (H 2 O) 5 .5 ; (c) Cu(II)(phenobarbital) 2 (H 2 O) 3 ; (d) Cu(II)(phenobarbital) 2 (pyridine) 2 ; (e) Cu(II)(phenobarbital) 2 (imidazole) 2 ; (f) Na 2 Cu(II)(phenobarbital) 4 ; (g) Cu(II)(amobarbital) 2 (H 2 O) 2 .5 ; (h) Cu(II)(amobarbital) 2 (H 2 O) 2 ; (i) Cu(II)(amobarbital) 2 (pyridine) 2 ; (j) Cu(II)(amobarbital) 2 (imidazole) 2 ; (k) Cu(II)(α-methyl-α-phenylsuccinimide); (l) Cu(II)5-ethyl-5-phenylhydantoin; (m) Cu(II)(N-thiopental) 2 ; and (n) Cu(II)(S-thiopental) 2 .
Claim 6
Dependent Claim
16 words
The method according to claim 1 or 2 wherein the organic copper compound is administered intravenously.
Claim 7
Dependent Claim
16 words
The method according to claim 1 or 2 wherein the organic copper compound is administered intraperitoneally.
Claim 8
Dependent Claim
16 words
The method according to claim 1 or 2 wherein the organic copper compound is administered subcutaneously.
Claim 9
Dependent Claim
16 words
The method according to claim 1 or 2 wherein the organic copper compound is administered orally.
Claim 10
Dependent Claim
16 words
The method according to claim 1 or 2 wherein the organic copper compound is administered topically.
Claim 11
Dependent Claim
30 words
The method according to claim 1 or 2 wherein the organic copper compound is administered in an amount between about 0.1 to about 100 milligrams per kilogram of body weight.
Claim 12
Dependent Claim
24 words
The method according to claim 1 or 2 wherein the organic copper compound is administered in the form of a solution, suspension or ointment.
Claim 13
Dependent Claim
23 words
The method according to claim 10 wherein the solution, suspension or ointment includes saline, ethylene glycol or a suspending agent like polyoxyethylene glycol.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-01 | 1990-12-01 | 1991-06-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-01 | 1994-12-01 | 1995-06-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-01 | 1998-12-01 | 1999-06-02 | $7700.00 | Window Closed / Lapsed |