US4666703A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Storage-stable, quick-disintegrating pressed shapes containing pharmaceutical active substances
Assignee: Novartis Corp
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Filing: 1985-03-13
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Granted: 1987-05-19
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Expires: 2005-03-13
Abstract
Abstract Storage stable, quick-disintegrating pressed shapes containing pharmaceutical active substances, which shapes consist substantially of a compressed mixture of (a) an effective amount of a pharmaceutical active substance in granular form, which is coated with a coating material comprising essentially a homogeneous mixture of a poly(H+meth)-acrylic acid-(methyl+ethyl) ester insoluble but dispersible in water and an ethyl cellulose insoluble but dispersible in water, the weight ratio of the acrylic acid ester to ethyl cellulose being 2.5:1 to 5:1; (b) talcum; and (c) colloidal silicon dioxide, and crosslinked polyvinylpolypyrrolidone as the disintegrating agent having a high disintegrating capacity and good binding properties.
Inventors
- 👤 Helmut Kopf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 10:43
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026; A61K9/5036; A61K9/5042; A61K9/5047
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
98 words
Storage-stable, quick-disintegrating pressed shapes containing pharmaceutical active substances, which shapes consist substantially of a compressed mixture of (a) an effective amount of a pharmaceutical active substance in granular form, which is coated with a coating material comprising essentially a homogeneous mixture of a poly(H+meth)-acrylic acid-(methyl+ethyl) ester insoluble but dispersible in water and an ethyl cellulose insoluble but dispersible in water, the weight ratio of the acrylic acid ester to ethyl cellulose being 2.5:1 to 5:1; (b) talcum; and (c) colloidal silicon dioxide, and crosslinked polyvinylpolypyrrolidone as the disintegrating agent having a high disintegrating capacity and good binding properties.
Claim 2
Dependent Claim
98 words
Storage-stable, quick-disintegrating pressed shapes containing pharmaceutical active substances, which shapes consist substantially of a compressed mixture of (a) an effective amount of a pharmaceutical active substance in granular form, which is coated with a coating material comprising essentially a homogeneous mixture of a poly(H+meth)-acrylic acid-(methyl+ethyl) ester insoluble but dispersible in water and an ethyl cellulose insoluble but dispersible in water, the weight ratio of the acrylic acid ester to ethyl cellulose being 2.5:1 to 5:1; (b) talcum; and (c) colloidal silicon dioxide, and crosslinked polyvinylpolypyrrolidone as the disintegrating agent having a high disintegrating capacity and good binding properties.
Claim 3
Dependent Claim
18 words
Pharmaceutical active-substance pressed shapes according to claim 1, wherein the mixture ratio of the coating materials is 3:1.
Claim 4
Dependent Claim
21 words
Pharmaceutical active-substance pressed shapes according to claim 1, wherein the disintegrating agent consists of a mixture of polyvinylpolypyrrolidone and microcrystalline cellulose.
Claim 5
Dependent Claim
24 words
Pharmaceutical active-substance pressed shapes according to claim 1, wherein the pharmaceutical active substance is potassium chloride having a particle size of 0.3-1.2 mm diameter.
Claim 6
Dependent Claim
24 words
Pharmaceutical active-substance pressed shapes according to claim 1, wherein the pharmaceutical active substance is potassium chloride having a particle size of 0.5-1.2 mm diameter.
References Cited (Backward Citations)
GB1380171A
Cited
GB1393374A
Cited
GB1540754A
Cited
EP0008780A2
Cited
GB2086725A
Cited
GB2087235A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-18 | 1990-11-17 | 1991-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-18 | 1994-11-17 | 1995-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-18 | 1998-11-17 | 1999-05-19 | $7700.00 | Window Closed / Lapsed |