US4666697A
Expired / Lapsed
US
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Radioactive diagnostic agent
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1983-12-05
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Granted: 1987-05-19
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Expires: 2003-12-05
Abstract
Abstract A radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound a methyleneimine linkage (-CH=N-) or a methyleneamine linkage (-2NH-) formed by the condensation between the formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage formed by the condensation between the formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond.
Inventors
- 👤 Keietsu Takahashi
- 👤 Nobuo Ueda
- 👤 Masaaki Hazue
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:27
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/10; A61K51/1093; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/61; A61K51/088; A61K2123/00
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
155 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneimine linkage (--CH═N--) or a methyleneamine linkage (--CH 2 NH--) between a formyl group in the polyformyl compound and an amino group in the chelating compound; (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 2
Dependent Claim
155 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneimine linkage (--CH═N--) or a methyleneamine linkage (--CH 2 NH--) between a formyl group in the polyformyl compound and an amino group in the chelating compound; (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 3
Dependent Claim
13 words
The chemical product according to claim 1, wherein the polyformyl compound is polyacrolein.
Claim 4
Dependent Claim
14 words
The chemical product according to claim 1, wherein the polyformyl compound is a poly(dialdehydosaccharide).
Claim 5
Dependent Claim
12 words
The chemical product according to claim 3, wherein the poly(dialdehydosaccharide) is dialdehydostarch.
Claim 6
Dependent Claim
12 words
The chemical product according to claim 3, wherein the poly(dialdehydosaccharide) is dialdehydodextran.
Claim 7
Dependent Claim
12 words
The chemical product according to claim 1, wherein the poly(dialdehydosaccharide) is dialdehydoamylose.
Claim 8
Dependent Claim
13 words
The chemical product according to claim 1, wherein the polyformyl compound is polymethacrolein.
Claim 9
Dependent Claim
24 words
The chemical product according to claim 1, wherein the amino group containing chelating compound is bonded to the polyformyl compound by the methyleneimine linkage.
Claim 10
Dependent Claim
24 words
The chemical product according to claim 1, wherein the amino group containing chelating compound is bonded to the polyformyl compound by the methyleneamine linkage.
Claim 11
Dependent Claim
25 words
The chemical product according to claim 1, wherein the amino group containing physiologically active substance is bonded to the polyformyl compound by a methyleneimine linkage.
Claim 12
Dependent Claim
25 words
The chemical product according to claim 1, wherein the amino group containing physiologically active substance is bonded to the polyformyl compound by a methyleneamine linkage.
Claim 13
Dependent Claim
29 words
The chemical product according to claim 1, wherein said radioactive elements are selected from the group consisting of 67 Ga, 68 Ga, 201 Tl, 111 In and 99m Tc.
Claim 14
Dependent Claim
29 words
The chemical product according to claim 2, wherein the product contains 2 to 4,000 units of said chelating compound and 1 to 4,000 units of said physiologically active substance.
Claim 15
Dependent Claim
29 words
The chemical product according to claim 3, wherein the product contains 2 to 4,000 units of said chelating compound and 1 to 4,000 units of said physiologically active substance.
Claim 16
Dependent Claim
29 words
The chemical product according to claim 4, wherein the product contains 2 to 4,000 units of said chelating compound and 1 to 4,000 units of said physiologically active substance.
Claim 17
Dependent Claim
29 words
The chemical product according to claim 5, wherein the product contains 2 to 4,000 units of said chelating compound and 1 to 4,000 units of said physiologically active substance.
Claim 18
Dependent Claim
29 words
The chemical product according to claim 6, wherein the product contains 2 to 4,000 units of said chelating compound and 1 to 4,000 units of said physiologically active substance.
Claim 19
Dependent Claim
15 words
The chemical product according to claim 1, wherein polyacrolein has 10 to 500 repeating units.
Claim 20
Dependent Claim
15 words
The chemical product according to claim 1, wherein polymethacrolein has 10 to 500 repeating units.
Claim 21
Dependent Claim
15 words
The chemical product according to claim 1, wherein poly(dialdehydosaccharide) has 10 to 500 repeating units.
Claim 22
Dependent Claim
20 words
The chemical product according to claim 1, wherein the physiologically active substances have a molecular weight up to about 100,000.
Claim 23
Dependent Claim
147 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of a polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneimine linkage (--CH═N--) between a formyl group in the polyformyl compound and an amino group in the chelating compound; (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneamine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance and reduced; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 24
Dependent Claim
147 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of a polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneimine linkage (--CH═N--) between a formyl group in the polyformyl compound and an amino group in the chelating compound; (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneamine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance and reduced; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 25
Dependent Claim
148 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneamine linkage (--CH 2 NH--) between a formyl group in the polyformyl compound and an amino group in the chelating compound, and reduced; (3) at least one unit of an amino-group containing physiologically active substances bonded to the polyformyl compound by a methyleneimine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 26
Dependent Claim
148 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneamine linkage (--CH 2 NH--) between a formyl group in the polyformyl compound and an amino group in the chelating compound, and reduced; (3) at least one unit of an amino-group containing physiologically active substances bonded to the polyformyl compound by a methyleneimine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 27
Dependent Claim
151 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of a polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneamine linkage (--CH 2 NH--) between a formyl group in the polyformyl compound and an amino group in the chelating compound, and reduced; (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneamine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance and reduced; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
Claim 28
Dependent Claim
151 words
A chemical product usable as a radioactive diagnostic agent which comprises: (1) a unit of a polyformyl compound selected from the group consisting of polyacrolein having from 3 to 4,000 repeating units, polymethacrolein having from 3 to 4,000 repeating units and poly(dialdehydosaccharide) having from 2 to 1,000 repeating units; (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneamine linkage (--CH 2 NH--) between a formyl group in the polyformyl compound and an amino group in the chelating compound, and reduced; (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneamine linkage between the formyl group in the polyformyl compound and an amino group in the physiologically active substance and reduced; and (4) at least two radioactive metallic elements each of which is bonded to a chelating compound through a chelating bond.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-18 | 1990-11-17 | 1991-05-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-18 | 1994-11-17 | 1995-05-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-18 | 1998-11-17 | 1999-05-19 | $7700.00 | Window Closed / Lapsed |