Amino acid ester renin inhibitors

Claim 1

A compound of the formula ##STR89## including a pharmaceutically acceptable salt thereof wherein: A is ##STR90## R 4 is --O--lower alkyl, --O--(CH 2 ) m --aryl, or --O--(CH 2 ) m --heterocyclo; m is zero, one, two, three or four; R 8 is hydrogen, ##STR91## R 10 is hydrogen, ##STR92## R 2 , R 3 , R 7 and R 9 are independently selected from the group consisting of hydrogen, lower alkyl, halo substituted lower alkyl, --(CH 2 ) n --aryl, --(CH 2 ) n --heterocyclo, --(CH 2 ) n --OH, --(CH 2 ) n --NH 2 , --(CH 2 ) n --SH, --(CH 2 ) n --S--lower alkyl, --(CH 2 ) 2 --S--(CH 2 ) 2 --NH 2 , ##STR93## and --(CH 2 ) n --cycloalkyl; n is an integer from 1 to 4; R 11 is ##STR94## R 1 is hydrogen, lower alkyl, --(CH 2 ) n --aryl, --(CH 2 ) n --cycloalkyl, ##STR95## the term lower alkyl refers to straight or branched chain radicals having up to seven carbon atoms; the term cycloalkyl refers to saturated rings of 4 to 7 carbon atoms; the term halogen refers to Cl, Br, and F; the term halo substituted lower alkyl refers to such lower alkyl groups in which one or more hydrogens have been replaced by Cl, Br, or F groups; the term aryl refers to phenyl, 1-naphthyl, 2-naphthyl, mono substituted phenyl, 1-naphthyl, or 2-naphthyl wherein said substituent is lower alkyl of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, halogen, hydroxy, amino, --NH--alkyl wherein alkyl is of 1 to 4 carbons, or --N(alkyl) 2 wherein alkyl is of 1 to 4 carbons, di or tri substituted phenyl, 1-naphthyl or 2-naphthyl wherein said substituents are methyl, methoxy, methylthio, halogen, or hydroxy; and the term heterocyclo refers to 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, imidazolyl, and indolyl.