US4665071A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3,6-disubstituted-1,8-naphthalimides and methods for their production and use
Assignee: Warner Lambert Co LLC
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Filing: 1985-01-22
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Granted: 1987-05-12
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Expires: 2005-01-22
Abstract
Abstract Chemical compounds are provided that are novel 3,6-disubstituted-1,8-naphthalimides (I), as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. Compounds of the invention have pharmacological properties and are useful antimicrobial agents and antitumor agents. ##STR1##
Inventors
- 👤 Robert K. Zee-Cheng
- 👤 Chia C. Cheng
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 13:02
CPC Classifications
C; C07; C07D; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/14
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
73 words
A pharmaceutical composition for treating an implantable solid tumor in a lower mammal comprising an antitumor effective amount of a compound having in free base form the structural formula I ##STR9## or a pharmaceutically acceptable salt thereof, where n is 2 or 3, R 1 and R 2 are H, lower alkyl, lower hydroxalkyl, pyrrolidinyl, morpholino, or piperidinyl, and Y is NO 2 or NH 2 in combination with a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
73 words
A pharmaceutical composition for treating an implantable solid tumor in a lower mammal comprising an antitumor effective amount of a compound having in free base form the structural formula I ##STR9## or a pharmaceutically acceptable salt thereof, where n is 2 or 3, R 1 and R 2 are H, lower alkyl, lower hydroxalkyl, pyrrolidinyl, morpholino, or piperidinyl, and Y is NO 2 or NH 2 in combination with a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
44 words
A method for treating an implantable solid tumor in a lower mammal which comprises administering an antitumor effective amount of a compound having the structural formula I according to claim 1, in combination with a pharmaceutically acceptable carrier, to a mammal in need thereof.
Claim 4
Dependent Claim
61 words
A pharmaceutical composition for treating an implantable solid tumor in a lower mammal comprising an antitumor effective amount of a compound having a free base form the structural formula I ##STR10## or a pharmaceutically acceptable salt thereof, where n is 2, R 1 and R 2 are lower alkyl and Y is NO 2 in combination with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
61 words
A pharmaceutical composition for treating an implantable solid tumor in a lower mammal comprising an antitumor effective amount of a compound having a free base form the structural formula I ##STR10## or a pharmaceutically acceptable salt thereof, where n is 2, R 1 and R 2 are lower alkyl and Y is NO 2 in combination with a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
33 words
A method for treating an implantable solid tumor in a lower mammal which comprises administering an antitumor effective amount of a pharmaceutical composition according to claim 3 to a mammal in need thereof.
References Cited (Backward Citations)
US3940398A
Cited
US4146720A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-11 | 1990-11-10 | 1991-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-11 | 1994-11-10 | 1995-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-11 | 1998-11-10 | 1999-05-12 | $7700.00 | Window Closed / Lapsed |