US4663146A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods and compositions for the diagnosis of bloodclots using plasminogen activator
Assignee: Bayer Pharma AG
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Filing: 1983-07-29
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Granted: 1987-05-05
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Expires: 2003-07-29
Abstract
Abstract Methods for detecting fibrin or fibrin clots in a host suspected of producing fibrin by: introducing labeled tissue plasminogen activator or a binding site fragment derived therefrom into the host's bloodstream and assaying for the presence of concentrations of labeled tissue plasminogen activator in said host. Also provided are kits for practicing the invention.
Inventors
- 👤 Michael J. Morser
- 👤 Marc A. Shuman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 21:11
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/86; A61K2123/00; G01N2333/00; G01N2333/435; G01N2333/745; G01N2333/75; G01N2333/90; G01N2333/914; G01N2333/948; G01N2333/972; G01N2333/9726
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
55 words
A method for detecting fibrin or fibrin clots in a host suspected of producing fibrin comprising: introducing a given amount of fibrin binding site fragment of tissue plasminogen activator which is labeled with a detectable indicator into the bloodstream of a host; and assaying for the presence of labeled binding site fragment in said host.
Claim 2
Independent Claim
55 words
A method for detecting fibrin or fibrin clots in a host suspected of producing fibrin comprising: introducing a given amount of fibrin binding site fragment of tissue plasminogen activator which is labeled with a detectable indicator into the bloodstream of a host; and assaying for the presence of labeled binding site fragment in said host.
Claim 3
Dependent Claim
44 words
A method as recited in claim 1 further comprising waiting for the unbound labeled fibrin binding site fragment of tissue plasminogen activator to be cleared from the bloodstream of the host prior to assaying for concentrations of labeled binding site fragment in said host.
Claim 4
Dependent Claim
22 words
A method as recited in claim 1 wherein said fibrin binding site fragment of tissue plasminogen activator is labeled with a radioisotope.
Claim 5
Dependent Claim
22 words
A method as recited in claim 3 wherein that fibrin binding site fragment of tissue plasminogen activator is labeled with 125 I.
Claim 6
Dependent Claim
64 words
A diagnostic kit for the detection and determination of fibrin or fibrin clots in a host suspected of producing fibrin, comprising: a given amount of fibrin binding site fragment of tissue plasminogen activator which is labeled with a detectable indicator; a pharmaceutically acceptable carrier suitable for injection into the blood stream of the host, which labeled fragment and carrier are packaged as a unit.
Claim 7
Dependent Claim
64 words
A diagnostic kit for the detection and determination of fibrin or fibrin clots in a host suspected of producing fibrin, comprising: a given amount of fibrin binding site fragment of tissue plasminogen activator which is labeled with a detectable indicator; a pharmaceutically acceptable carrier suitable for injection into the blood stream of the host, which labeled fragment and carrier are packaged as a unit.
Claim 8
Dependent Claim
24 words
A diagnostic kit as recited in claim 5 wherein said labeled fibrin binding site fragment of tissue plasminogen activator is labeled with a radioisotope.
Claim 9
Dependent Claim
14 words
A diagnostic kit as recited in claim 6 wherein said radioisotope is 125 I.
References Cited (Backward Citations)
US4381346A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-04 | 1990-11-03 | 1991-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-04 | 1994-11-03 | 1995-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-04 | 1998-11-03 | 1999-05-05 | $7700.00 | Window Closed / Lapsed |