US4662359A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of magnetic susceptibility probes in the treatment of cancer
Assignee: GORDON DAVID SKOKIE ILLINOIS
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Filing: 1983-09-23
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Granted: 1987-05-05
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Expires: 2003-09-23
Abstract
Abstract Described is a process for the treatment of cancer in at least one region of host organism containing cancer cells and normal cells without substantially damaging living normal cells comprising: providing to a host organism minute particles capable of being inductively heated and of size capable of being absorbed into cancer cells, determining, after a period of metabolic time, the magnetic susceptibility of the particles with said region, subjecting the organism to an alternating electromagnetic field to inductively heat said particles at that point in metabolic time when the maximum difference in magnetic susceptibility between the cancer cell and normal cells within said region occurs, and continuing the inductive heating of said particles to attain an increase in intracellular temperature to selectively kill the cancer cells.
Inventors
- 👤 Robert T. Gordon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 10:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; A61K41/00; A61K41/0052
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
129 words
A process for the treatment of cancer in at least one region of a host organism containing cancer cells and normal cells without substantially damaging living normal cells comprising: providing to a host organism minute particles capable of being inductively heated and of a size capable of being absorbed into cancer cells, determining, after a period of metabolic time, the magnetic susceptibility of the particles within said region, subjecting the organism to an alternating, oscillating or pulsed electromagnetic field to inductively heat said particles at that point in metabolic time when the maximum difference in magnetic susceptibility between the cancer cell and normal cell within said region occurs, and continuing the induction heating of said particles to attain an increase in intracellular temperature to selectively kill the cancer cells.
Claim 2
Dependent Claim
129 words
A process for the treatment of cancer in at least one region of a host organism containing cancer cells and normal cells without substantially damaging living normal cells comprising: providing to a host organism minute particles capable of being inductively heated and of a size capable of being absorbed into cancer cells, determining, after a period of metabolic time, the magnetic susceptibility of the particles within said region, subjecting the organism to an alternating, oscillating or pulsed electromagnetic field to inductively heat said particles at that point in metabolic time when the maximum difference in magnetic susceptibility between the cancer cell and normal cell within said region occurs, and continuing the induction heating of said particles to attain an increase in intracellular temperature to selectively kill the cancer cells.
Claim 3
Dependent Claim
53 words
The process of claim 1 including the further step of applying a localized, static field to aid in the intracellular uptake and the energy-absorption responsiveness of said particles, said field being applied after the provision of the particles to the host organism but prior to or during the application of said electromagentic field.
Claim 4
Dependent Claim
20 words
The process of claim 2 wherein the strength of static field is between about 500 gauss to about 80 kilogauss.
Claim 5
Dependent Claim
35 words
The process according to claim 1 wherein said induction heating is continued to attain an increase in intracellular temperature of said cancer cells of between 8° C. and 100° C. to kill said cancer cells.
Claim 6
Dependent Claim
35 words
The process according to claim 1 wherein said induction heating is continued to attain an increase in intracellular temperature of at least 8.0° Centigrade and not greater than 9.5° Centigrade to kill said cancer cells.
Claim 7
Dependent Claim
82 words
A process for treating a host organism including a cell population constituting an invasive abnormality comprising introducing within the host phagocytizable particles capable of being inductively heated in response to an imposed high frequency alternating electromagnetic field inductively heating said particles, wherein the time of treatment to effect said inductive heating under conditions to selectively alternate or kill the said cell population is correlated with the maximum responsiveness of particles in said cell population measured by the magnetic susceptibility of said particles.
Claim 8
Dependent Claim
82 words
A process for treating a host organism including a cell population constituting an invasive abnormality comprising introducing within the host phagocytizable particles capable of being inductively heated in response to an imposed high frequency alternating electromagnetic field inductively heating said particles, wherein the time of treatment to effect said inductive heating under conditions to selectively alternate or kill the said cell population is correlated with the maximum responsiveness of particles in said cell population measured by the magnetic susceptibility of said particles.
Claim 9
Dependent Claim
53 words
The process of claim 6 including the further step of applying a localized, static field to aid in the intracellular uptake and energy absorption responsiveness of said particles, said field being applied after the provision of the particles to the host organism but prior to or during the application of said electromagnetic field.
Claim 10
Dependent Claim
21 words
The process according to claim 6 wherein the strength of said static field is between about 500 gauss and 80 kilogauss.
Claim 11
Dependent Claim
34 words
The process according to claim 6 wherein induction heating is continued to attain an increase in intracellular temperature of said cancer cells of between 8° C. and 100° C. to kill said cancer cells.
Claim 12
Dependent Claim
35 words
The process according to claim 6 wherein said induction heating is continued to attain an increase in intracellular temperature of at least 8.0° Centigrade and not greater than 9.5° Centigrade to kill said cancer cells.
Claim 13
Dependent Claim
112 words
A process for the treatment of cancer in at least one region of a host organism containing cancer cells and normal cells without substantially damaging living normal cells comprising: providing to the host organism minute encapsulated tumoricidal material, said encapsulating material capable of being removed upon entering the cancer cell, determining after a period of metabolic time, the magnetic susceptibility of the particles with said region, subjecting the organism to an alternating, oscillating or pulsed electromagnetic field at that point in metabolic time when the maximum difference in magnetic susceptibility between the cancer cells and normal cells occurs thereby removing said encapsulating material and releasing said tumoricidal material within the cancer cells.
Claim 14
Dependent Claim
112 words
A process for the treatment of cancer in at least one region of a host organism containing cancer cells and normal cells without substantially damaging living normal cells comprising: providing to the host organism minute encapsulated tumoricidal material, said encapsulating material capable of being removed upon entering the cancer cell, determining after a period of metabolic time, the magnetic susceptibility of the particles with said region, subjecting the organism to an alternating, oscillating or pulsed electromagnetic field at that point in metabolic time when the maximum difference in magnetic susceptibility between the cancer cells and normal cells occurs thereby removing said encapsulating material and releasing said tumoricidal material within the cancer cells.
Claim 15
Dependent Claim
24 words
The method according to claim 11 wherein in response to said electromagnetic field said particle is inductively heated and said encapsulating material is melted.
Claim 16
Dependent Claim
24 words
The method according to claim 11 wherein in response to said electromagnetic field said particle vibrates thereby destroying the integrity of the encapsulating material.
Claim 17
Dependent Claim
23 words
The method according to claim 11 wherein said tumoricidal material is selected from the group consisting of antibodies, radioactive isotopes, and chemotherapeutic agents.
Claim 18
Dependent Claim
26 words
The method according to claim 14 wherein said chemotherapeutic agent is selected from the group consisting of 5-flurouracil, nitrogen mustard, actinomycin D, methotrexate, cytoxan and vincristine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-04 | 1990-11-03 | 1991-05-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-04 | 1994-11-03 | 1995-05-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-04 | 1998-11-03 | 1999-05-05 | $7700.00 | Window Closed / Lapsed |