US4657931A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-(acyldipeptidyl)-aminoglycols
Assignee: GD Searle LLC
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Filing: 1985-05-15
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Granted: 1987-04-14
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Expires: 2005-05-15
Abstract
Abstract A compound of the formula: ##STR1## wherein R 1 is alkoxy containing one to six carbon atoms or lower alkyl containing one to six carbon atoms; R 2 is benzyl or napthylmethyl, R 3 is lower alkyl containing one to six carbon atoms or imidazolemethyl; R 4 is benzyl, R 5 is hydrogen or lower alkyl and n is 0 or 1. These compounds are useful as renin inhibitors.
Inventors
- 👤 John S. Baran
- 👤 Gunnar J. Hanson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:53
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06078; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07K5/02; C07K5/0227; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/86
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
61 words
A compound of the formula: ##STR15## wherein R 1 is alkoxy containing one to six carbon atoms or alkyl containing one to six carbon atoms; R 2 is benzyl or napthylmethyl, R 3 is lower alkyl containing one to six carbon atoms or imidazolemethyl; R 4 is benzyl, R 5 is hydrogen or lower alkyl and n is 0 or 1.
Claim 2
Dependent Claim
61 words
A compound of the formula: ##STR15## wherein R 1 is alkoxy containing one to six carbon atoms or alkyl containing one to six carbon atoms; R 2 is benzyl or napthylmethyl, R 3 is lower alkyl containing one to six carbon atoms or imidazolemethyl; R 4 is benzyl, R 5 is hydrogen or lower alkyl and n is 0 or 1.
Claim 3
Dependent Claim
16 words
A compound of chain 1 wherein R 3 is lower alkyl containing one to six carbons.
Claim 4
Dependent Claim
16 words
A compound of chain 1 wherein R 3 is lower alkyl containing one to six carbons.
Claim 5
Dependent Claim
10 words
A compound of claim 1 wherein R 3 is imidazolemethyl.
Claim 6
Dependent Claim
8 words
A compound according to claim 2 comprising N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[2S,4-dihydroxy-1S-(phenylmethyl)butyl]-L-leucinamide.
Claim 7
Dependent Claim
8 words
A compound according to claim 2 comprising N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[(2R,3-dihydroxy-1S-(phenylmethyl)propyl]-L-leucinamide.
Claim 8
Dependent Claim
8 words
A compound according to claim 2 comprising N-[(1,1-dimethylethoxy)carbonyl]-3-(1-naphthalenyl)-L-alanyl-N-[2R,3-dihydroxy-1S-(phenylmethyl)propyl]-L-leucinamide.
Claim 9
Dependent Claim
8 words
A compound according to claim 3 comprising N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-N-[2R,3-dihydroxy-1S-(phenylmethyl)propyl]-L-histidinamide.
Claim 10
Dependent Claim
8 words
A compound according to claim 2 comprising N-(3,3-dimethyl-1-oxobutyl)-L-phenylalanyl-N-[2R,3-dihydroxy-1S-(phenylmethyl)propyl]-L-leucinamide.
Claim 11
Dependent Claim
20 words
A renin-inhibiting composition of matter comprising a therapeutically effective amount of the compound of claim 1 suitable for pharmaceutical administration.
Claim 12
Dependent Claim
9 words
The composition of claim 9 suitable for oral administration.
Claim 13
Dependent Claim
9 words
The composition of claim 9 suitable for parenteral administration.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-13 | 1990-10-13 | 1991-04-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-13 | 1994-10-13 | 1995-04-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-13 | 1998-10-13 | 1999-04-14 | $7700.00 | Window Closed / Lapsed |