US4655898A
Expired / Lapsed
US
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Electrophoretic fractionation apparatus
Assignee: Rhone Poulenc Recherches SA
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Filing: 1986-06-26
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Granted: 1987-04-07
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Expires: 2006-06-26
Abstract
Abstract Electrophoretic fractionation apparatus well adopted for separating solutions containing diverse substances dissolved therein, e.g., such proteinaceous solutions as human plasma, is comprised of (i) a pair of opposed end plates, (ii) a pair of opposed electrodes, (iii) a pair of opposed frame members, (iv) at least two spaced membranes, said frame members, electrodes and membranes defining open electrode compartments between said end plates, and said frame members comprising inlet and outlet means for introducing and withdrawing an ionic solution into and from the central region of said electrode compartments, and (v) at least one fractionation plate disposed between said at least two membranes, and each said fractionation plate (v) comprising (1) at least one elongate slit extending through the thickness thereof and said slit defining, together with two of said spaced membranes, at least one solution fractionation chamber, (2) means for introducing solution to be fractionated into said at least one fractionation chamber, (3) means for withdrawing one fraction of fractionated solution from one end region of said fractionation chamber, and (4) means for withdrawing another fraction of fractionated solution from another end region of said fractionation chamber.
Inventors
- 👤 Marie-Andree Poulhes
- 👤 Jean-Pierre Lafaille
- 👤 Jacques Pourrat
- 👤 Victor Sanchez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:08
CPC Classifications
B; B01; B01D; B01D61/00; B01D61/42; B01D61/425; A; A61; A61M; A61M1/00; A61M1/36; B01D57/00; B01D57/02; B01D63/00; B01D63/08; B01D63/082; B01D63/0822; G; G01; G01N; G01N27/00; G01N27/26; G01N27/416; G01N27/447; G01N27/44756; G01N27/44769
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
193 words
Electrophoretic fractionation apparatus adopted for separating solutions containing diverse substances dissolved therein, comprising (i) a pair of opposed end plates, (ii) a pair of opposed electrodes, (iii) a pair of opposed frame members, (iv) at least two spaced membranes, said frame members, electrodes and membranes defining open electrode compartments between said end plates, and said frame members comprising inlet and outlet means for introducing and withdrawing an ionic solution into and from the central region of said electrode compartments, and (iv) at least one fractionation plate disposed between said at least two membranes, the plate having a greater length than width, and each said fractionation plate (v) comprising (1) at least one elongate slit extending along the length of the plate and through the thickness thereof and said slit defining, together with two of said spaced membranes, at least one solution fractionation chamber, (2) means for introducing solution to be fractionated into said at least one fractionation chamber, (3) means for withdrawing one fraction of fractionated solution from one end region of said fractionation chamber, and (4) means for withdrawing another fraction of fractionated solution from another end region of said fractionation chamber.
Claim 2
Dependent Claim
193 words
Electrophoretic fractionation apparatus adopted for separating solutions containing diverse substances dissolved therein, comprising (i) a pair of opposed end plates, (ii) a pair of opposed electrodes, (iii) a pair of opposed frame members, (iv) at least two spaced membranes, said frame members, electrodes and membranes defining open electrode compartments between said end plates, and said frame members comprising inlet and outlet means for introducing and withdrawing an ionic solution into and from the central region of said electrode compartments, and (iv) at least one fractionation plate disposed between said at least two membranes, the plate having a greater length than width, and each said fractionation plate (v) comprising (1) at least one elongate slit extending along the length of the plate and through the thickness thereof and said slit defining, together with two of said spaced membranes, at least one solution fractionation chamber, (2) means for introducing solution to be fractionated into said at least one fractionation chamber, (3) means for withdrawing one fraction of fractionated solution from one end region of said fractionation chamber, and (4) means for withdrawing another fraction of fractionated solution from another end region of said fractionation chamber.
Claim 3
Dependent Claim
17 words
The apparatus as defined by claim 1, said at least one elongate slit (1) being generally vertical.
Claim 4
Dependent Claim
29 words
The apparatus as defined by claim 1, said at least one elongate slit (1) being angled with respect to the longitudinal axis of said at least one fractionation plate.
Claim 5
Dependent Claim
32 words
The apparatus as defined by claim 1, said means (2) opening into said slit (1) at a distance no more than half the length of said slit, measured from the base thereof.
Claim 6
Dependent Claim
23 words
The apparatus as defined by claim 4, said means (2) opening into said slit (1) at least 1 cm from the base thereof.
Claim 7
Dependent Claim
23 words
The apparatus as defined by claim 5, said means (2) opening into said slit (1) at least 2 cm from the base thereof.
Claim 8
Dependent Claim
32 words
The apparatus as defined by claim 6, said means (2) opening into said slit (1) at a distance no more than one-quarter the length of said slit, measured from the base thereof.
Claim 9
Dependent Claim
15 words
The apparatus as defined by claim 1, further comprising means for the leakproof clamping thereof.
Claim 10
Dependent Claim
24 words
The apparatus as defined by claim 1, comprising a plurality of fractionation plates (v), each such fractionation plate being sandwiched between two membranes (iv).
Claim 11
Dependent Claim
32 words
The apparatus as defined by claim 1, said means (2) comprising an aperture extending through the thickness of the fractionation plate, and said aperture communicating with a conduit into said slit (1).
Claim 12
Dependent Claim
18 words
The apparatus as defined by claim 10, each respective membrane comprising a hole in registration with said aperture.
Claim 13
Dependent Claim
54 words
The apparatus as defined by claim 1, said means (4) being at the base of said slit (1) and more proximate the anode facing surface of the fractionation plate, and said means (3) being at the upper end region of said slit (1) and more proximate the cathode facing surface of the fractionation plate.
Claim 14
Dependent Claim
35 words
The apparatus as defined by claim 12, said means (4) comprising a channel or duct communicating with the base of said slit (1) and with a hole extending through the thickness of the fractionation plate.
Claim 15
Dependent Claim
37 words
The apparatus as defined by claim 13, said means (3) comprising a channel or duct communicating with the upper end region of said slit (1) and with a hole extending through the thickness of the fractionation plate.
Claim 16
Dependent Claim
29 words
The apparatus as defined by claim 14, each membrane contiguous each fractionation plate comprising holes extending through the thickness thereof in registration with the holes through the fractionation plate.
Claim 17
Dependent Claim
19 words
The apparatus as defined by claim 1, the thickness of each fractionation plate ranging from 1.3 to 1.7 mm.
Claim 18
Dependent Claim
21 words
The apparatus as defined by claim 16, each said slit (1) having a width to length ratio of less than 1:5.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-06 | 1990-10-06 | 1991-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-06 | 1994-10-06 | 1995-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-06 | 1998-10-06 | 1999-04-07 | $7700.00 | Window Closed / Lapsed |