US4654353A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihypertensive 2-hydroxyalkoxyalkyl dihydropyridines
Assignee: Pfizer Inc
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Filing: 1985-04-26
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Granted: 1987-03-31
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Expires: 2005-04-26
Abstract
Abstract Compounds of the formula: <IMAGE> (I) where R is an optionally substituted aryl or heteroaryl group; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; and Y is -(CH2)n- where n is 2, 3 or 4, -CH2CH(CH3)- or -Ch2C(CH3)2-; and their pharmaceutically acceptable salts. The compounds have utility as anti-ischaemic and antihypertensive agents and as synthetic intermediates to other dihydropyridine calcium antagonists.
Inventors
- 👤 David Alker
- 👤 Simon F. Campbell
- 👤 Peter E. Cross
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:48
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; A; A61; A61P; A61P3/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90; C07D401/12
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
68 words
A compound of the formula ##STR19## where R is selected from the group consisting of 2-chlorophenyl, 2,3-dichlorophenyl, 2-chloro-3-trifluoromethylphenyl and 2-chloropyrid-3-yl; R 1 and R 2 are each independently C 1 -C 4 alkyl or 2-methoxyethyl; Y is --(CH 2 ) n --, --CH 2 CH(CH 3 )-- or --CH 2 C(CH 3 ) 2 --; and n is 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
68 words
A compound of the formula ##STR19## where R is selected from the group consisting of 2-chlorophenyl, 2,3-dichlorophenyl, 2-chloro-3-trifluoromethylphenyl and 2-chloropyrid-3-yl; R 1 and R 2 are each independently C 1 -C 4 alkyl or 2-methoxyethyl; Y is --(CH 2 ) n --, --CH 2 CH(CH 3 )-- or --CH 2 C(CH 3 ) 2 --; and n is 2, 3 or 4; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
12 words
A compound according to claim 1 wherein R is 2-chlorophenyl or 2,3-dichlorophenyl.
Claim 4
Dependent Claim
32 words
A compound according to claim 2 wherein Y is --(CH 2 ) 2 --, --(CH 2 ) 4 , CH 2 CH(CH 3 )-- or --CH 2 C(CH 3 ) 2 --.
Claim 5
Dependent Claim
16 words
A compound according to claim 3 wherein R 1 is methyl and R 2 is ethyl.
Claim 6
Dependent Claim
24 words
A pharmaceutical composition comprising an anti-ischaemic or antihypertensive effective amount of a compound according to claim 1 and a pharmaceutically acceptable diluent or carrier.
Claim 7
Dependent Claim
24 words
A method of treating ischaemia in a mammal comprising the step of administering an anti-ischaemic effective amount of a compound according to claim 1.
Claim 8
Dependent Claim
24 words
A method of treating hypertension in a mammal comprising the step of administering an antihypertensive effective amount of a compound according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-30 | 1990-09-29 | 1991-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-30 | 1994-09-29 | 1995-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-30 | 1998-09-29 | 1999-03-31 | $7700.00 | Window Closed / Lapsed |