US4650772A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Monoclonal antibody stabilization
Assignee: Abbott Laboratories
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Filing: 1984-08-09
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Granted: 1987-03-17
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Expires: 2004-08-09
Abstract
Abstract A solution containing from about 0.25% to about 5% hydrolyzed ovalbumin by weight provides surprising thermal stabilization of monoclonal antibodies.
Inventors
- 👤 Robert H. Dodge
- 👤 Randall J. Avers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:42
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/395; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/577; G01N33/5306; Y; Y10; Y10S; Y10S436/00; Y10S436/825; Y10S436/826
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
37 words
A method for stabilizing a thermally unstable monoclonal antibody against thermal degradation, comprising incorporating the antibody in an aqueous solution containing from about 0.25% to about 5% hydrolyzed ovalbumin by weight, whereby said antibody is thermally stabilized.
Claim 2
Independent Claim
37 words
A method for stabilizing a thermally unstable monoclonal antibody against thermal degradation, comprising incorporating the antibody in an aqueous solution containing from about 0.25% to about 5% hydrolyzed ovalbumin by weight, whereby said antibody is thermally stabilized.
Claim 3
Dependent Claim
18 words
A method according to claim 1 in which the aqueous solution contains about 1% hydrolyzed ovalbumin by weight.
Claim 4
Dependent Claim
34 words
A thermally stable monoclonal antibody composition comprising an aqueous solution containing from 0.5 nmol to 0.5 umol thermally unstable monoclonal antibody per ml., and from about 0.25% to about 5% hydrolyzed ovalbumin by weight.
Claim 5
Dependent Claim
34 words
A thermally stable monoclonal antibody composition comprising an aqueous solution containing from 0.5 nmol to 0.5 umol thermally unstable monoclonal antibody per ml., and from about 0.25% to about 5% hydrolyzed ovalbumin by weight.
Claim 6
Dependent Claim
14 words
A composition according to claim 3 which contains about 1% hydrolyzed ovalbumin by weight.
Claim 7
Dependent Claim
15 words
A composition according to claim 4 which further contains about 0.9% sodium chloride by weight.
Claim 8
Dependent Claim
13 words
A composition according to claim 5 which has a pH of about 5.5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |