US4649929A
Expired / Lapsed
US
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Method and apparatus for diagnosis of coronary artery disease
Assignee: SRI International Inc
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Filing: 1981-06-11
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Granted: 1987-03-17
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Expires: 2001-06-11
Abstract
Abstract Method and apparatus for recurrently obtaining a measure of the systolic slope of the blood pressure wave in a subject's artery during a range of physical activity, or exercise, are disclosed. A plot, or record, of the slope measurements versus heart beat rate, point in an exercise protocol, or the like, is provided from which subjects having coronary artery disease (CAD) may be distinguished from subjects without CAD.
Inventors
- 👤 Charles S. Weaver
- 👤 Constance T. Chittenden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:00
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/02; A61B5/021; A61B5/022; A61B5/02208; A61B5/026; A61B5/0285; A61B5/22; A61B5/221; A61B5/222
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
90 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, and using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, the measurements being recurrently obtained while the subject exercises aerobically on a treadmill, stationary bicycle, or the like, a systolic slope which increases then decreases during exercise being indicative of coronary artery disease in the subject.
Claim 2
Independent Claim
90 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, and using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, the measurements being recurrently obtained while the subject exercises aerobically on a treadmill, stationary bicycle, or the like, a systolic slope which increases then decreases during exercise being indicative of coronary artery disease in the subject.
Claim 3
Independent Claim
99 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, and using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, the measurements being recurrently obtained prior to and for a period of time immediately after a period of aerobic exercise by the subject, a systolic slope after exercise which is less than the pre-exercise systolic slope being indicative of coronary artery disease in the subject.
Claim 4
Independent Claim
99 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, and using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, the measurements being recurrently obtained prior to and for a period of time immediately after a period of aerobic exercise by the subject, a systolic slope after exercise which is less than the pre-exercise systolic slope being indicative of coronary artery disease in the subject.
Claim 5
Independent Claim
116 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, and using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, said measurements being recurrently obtained prior to, during, and while resting after aerobic exercise, a systolic slope prior to exercise which is less than that of individuals without coronary artery disease, a systolic slope which increases then decreases during exercise, and a systolic slope while resting after exercise less than that at pre-exercise, being indicative of coronary artery disease in the subject.
Claim 6
Independent Claim
116 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, and using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, said measurements being recurrently obtained prior to, during, and while resting after aerobic exercise, a systolic slope prior to exercise which is less than that of individuals without coronary artery disease, a systolic slope which increases then decreases during exercise, and a systolic slope while resting after exercise less than that at pre-exercise, being indicative of coronary artery disease in the subject.
Claim 7
Independent Claim
87 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject before, during and after aerobic exercise, using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, obtaining a measure of heart rate while measurements of systolic slope are obtained, and plotting measurements of the systolic slope versus heart rate to provide a record thereof.
Claim 8
Independent Claim
87 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject before, during and after aerobic exercise, using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, obtaining a measure of heart rate while measurements of systolic slope are obtained, and plotting measurements of the systolic slope versus heart rate to provide a record thereof.
Claim 9
Independent Claim
72 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, and plotting measurements of the systolic slope versus time obtained during an aerobic exercise protocol performed by the subject.
Claim 10
Independent Claim
72 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining measurements of the systolic slope of an arterial blood pressure wave of the subject, using differences in said slope measurements from slope measurements obtained from individuals without coronary artery disease as an indication of coronary artery disease in the subject, and plotting measurements of the systolic slope versus time obtained during an aerobic exercise protocol performed by the subject.
Claim 11
Independent Claim
85 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining recurrent measurements of the systolic slope of an arterial blood pressure wave of the subject during an exercise cycle which includes pre-exercise rest, aerobic exercise on a treadmill, stationary bicycle, or the like, and post-exercise rest portions, determining whether said slope measurements are characteristic of slope measurements obtained from individuals without coronary artery disease during a similar aerobic exercise cycle, coronary artery disease being indicated by characteristic differences in said slope measurements.
Claim 12
Independent Claim
85 words
A method of detecting coronary artery disease in a subject comprising non-invasively obtaining recurrent measurements of the systolic slope of an arterial blood pressure wave of the subject during an exercise cycle which includes pre-exercise rest, aerobic exercise on a treadmill, stationary bicycle, or the like, and post-exercise rest portions, determining whether said slope measurements are characteristic of slope measurements obtained from individuals without coronary artery disease during a similar aerobic exercise cycle, coronary artery disease being indicated by characteristic differences in said slope measurements.
Claim 13
Dependent Claim
101 words
A method as defined in claim 6 wherein recurrent measurements of systolic slope are obtained non-invasively using an inflatable cuff with a transducer responsive to cuff pressure, R-wave detecting means and Korotkov sound detecting means from which transducer and detecting means blood pressure, R-wave and Korotkov sound signals are obtained, respectively, recurrently processing said signals to obtain signals related to the slope of a straight line fitted to R-wave-Korotkov sound intervals versus cuff pressure during cuff deflations between systolic and diastolic blood pressures, which slope related signals are related to the systolic slope of blood pressure waves during said cuff deflations.
Claim 14
Dependent Claim
25 words
A method as defined in claim 7 including recording said slope related signals versus heart rate of the subject obtained from processing said R-wave signals.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |