US4644070A
Expired / Lapsed
US
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Chroman-3-ol compounds
Assignee: Beecham Group PLC
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Filing: 1984-12-18
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Granted: 1987-02-17
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Expires: 2004-12-18
Abstract
Abstract Anti-hypertensive compounds of formula (I): ##STR1## wherein: one of R 1 and R 2 is nitro, cyano or C 1-3 alkylcarbonyl, and the other is methoxy or amino optionally substituted by one or two C 1-6 alkyl or by C 2-7 alkanoyl; one of R 3 and R 4 is hydrogen or C 1-4 alkyl and the other is C 1-4 alkyl, or R 3 and R 4 together with the carbon atom to which they are attached are C 3-6 spiroalkyl; R 5 is hydrogen, C 1-3 alkyl or C 1-8 acyl; and n is 1 or 2; the lactam group being trans to the OR 5 group; or, when the other of R 1 and R 2 is amino, a pharmaceutically acceptable salt thereof.
Inventors
- 👤 John M. Evans
- 👤 Robin E. Buckingham
- 👤 Kenneth Willcocks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 18:51
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/04; A; A61; A61P; A61P9/00; A61P9/12; C07D311/00; C07D311/02; C07D311/04; C07D311/58; C07D311/68; C07D311/70
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
152 words
A compound of the formula: ##STR19## wherein: one of R 1 ' and R 2 ' is nitro, cyano, C 1-3 alkylcarbonyl, hydrogen or α-hydroxymethyl, and the other is methoxy, amino optionally substituted by one of two C 1-6 alkyl or by C 2-7 alkanoyl, or hydroxy or halo; one of R 3 and R 4 is hydrogen or C 1-4 alkyl and the other is C 1-4 alkyl, or R 3 and R 4 together with the carbon atom to which they are attached are C 3-6 spiroalkyl; R 5 is hydrogen, C 1-3 alkyl or C 1-8 alkanoyl or benzoyl; one of X and Y is CO and the other is (CH) n+2 ; n is 1 or 2; L 1 is chloro when X is CO and is hydroxy or C 1-4 alkoxy when Y is CO; and the substituted amino group is trans to the OR 5 group.
Claim 2
Dependent Claim
152 words
A compound of the formula: ##STR19## wherein: one of R 1 ' and R 2 ' is nitro, cyano, C 1-3 alkylcarbonyl, hydrogen or α-hydroxymethyl, and the other is methoxy, amino optionally substituted by one of two C 1-6 alkyl or by C 2-7 alkanoyl, or hydroxy or halo; one of R 3 and R 4 is hydrogen or C 1-4 alkyl and the other is C 1-4 alkyl, or R 3 and R 4 together with the carbon atom to which they are attached are C 3-6 spiroalkyl; R 5 is hydrogen, C 1-3 alkyl or C 1-8 alkanoyl or benzoyl; one of X and Y is CO and the other is (CH) n+2 ; n is 1 or 2; L 1 is chloro when X is CO and is hydroxy or C 1-4 alkoxy when Y is CO; and the substituted amino group is trans to the OR 5 group.
Claim 3
Dependent Claim
21 words
The compound according to claim 1, wherein X is CO, Y is (CH 2 ) n+2 and L 1 is chloro.
Claim 4
Dependent Claim
26 words
The compound according to claim 1, wherein X is (CH 2 ) n+2 , Y is CO and L 1 is hydroxy or C 1-4 alkoxy.
References Cited (Backward Citations)
US4446113A
Cited
US4446113B1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-16 | 1990-08-18 | 1991-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-16 | 1994-08-18 | 1995-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-16 | 1998-08-18 | 1999-02-17 | $7700.00 | Window Closed / Lapsed |