US4644059A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
Assignee: Sanofi Vaccines US Inc
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Filing: 1985-01-16
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Granted: 1987-02-17
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Expires: 2005-01-16
Abstract
Abstract A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, is prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.
Inventors
- 👤 Lance K. Gordon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 10:18
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/102; A61K2039/60; A61K2039/6031; A61K2039/6037; Y; Y10; Y10S; Y10S424/00; Y10S424/831
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
46 words
A hapten prepared from capsular Haemophilus influenzae b polysaccharide, consisting of approximately equal parts of ribose, ribitol and phosphate, by heating until less than 20% is of a molecular size is below 200,000 dalton and less than 20% is of molecular size greater than 2,000,000 dalton.
Claim 2
Dependent Claim
46 words
A hapten prepared from capsular Haemophilus influenzae b polysaccharide, consisting of approximately equal parts of ribose, ribitol and phosphate, by heating until less than 20% is of a molecular size is below 200,000 dalton and less than 20% is of molecular size greater than 2,000,000 dalton.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-16 | 1990-08-18 | 1991-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-16 | 1994-08-18 | 1995-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-16 | 1998-08-18 | 1999-02-17 | $7700.00 | Window Closed / Lapsed |