US4642293A
Expired / Lapsed
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Novel hybridoma cell line producing monoclonal antibodies against laminin and a process for the production thereof
Assignee: University of Pittsburgh
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Filing: 1983-03-24
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Granted: 1987-02-10
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Expires: 2003-03-24
Abstract
Abstract The invention relates to a novel hybridoma continuous cell line that produces a monoclonal antibody of the IgG type to the glycoprotein GP-2, a subunit of the basement membrane component laminin. The hybridoma cell line is formed from a spleen cell from a Lewis rat, which has been immunized with a basement membrane antigen, fused with a mouse myeloma cell.
Inventors
- 👤 Albert E. Chung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:30
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
65 words
The composition assigned ATCC Accession Number HB 8210 comprising a hybrid continuous cell line that produces a monoclonal antibody of the IgG type to the glycoprotein GP-2, a subunit of the basement membrane component laminin, said cell line comprising a spleen cell from a Lewis rat, immunized with a M-1536-B3 basement membrane component that contains the GP-2 antigen, fused with a mouse SP2/0-Ag14 myeloma cell.
Claim 2
Dependent Claim
65 words
The composition assigned ATCC Accession Number HB 8210 comprising a hybrid continuous cell line that produces a monoclonal antibody of the IgG type to the glycoprotein GP-2, a subunit of the basement membrane component laminin, said cell line comprising a spleen cell from a Lewis rat, immunized with a M-1536-B3 basement membrane component that contains the GP-2 antigen, fused with a mouse SP2/0-Ag14 myeloma cell.
Claim 3
Dependent Claim
18 words
The composition of claim 1 wherein the composition includes a culture medium for said hybrid continuous cell line.
Claim 4
Dependent Claim
11 words
The composition of claim 2 wherein the culture medium contains hypoxanthine-aminopterinthymidine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-09 | 1990-08-11 | 1991-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-09 | 1994-08-11 | 1995-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-09 | 1998-08-11 | 1999-02-10 | $7700.00 | Window Closed / Lapsed |