US4642234A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Disinfection of contact lenses
Assignee: University of Bath
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Filing: 1984-09-12
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Granted: 1987-02-10
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Expires: 2004-09-12
Abstract
Abstract Hydrophilic soft contact lenses are disinfected by soaking in a non-eye-irritant aqueous disinfecting solution obtained by the addition to tap water of a chlorhexidine salt, a sequestering agent for calcium and magnesium ions, and a dechlorinating agent. Suitably, the solution is obtained by dissolving a tablet in tap water. The preferred sequestering agent is sodium tripolyphosphate and the preferred dechlorinating agent is sodium thiosulphate. Advantageously, the chlorhexidine salt is provided in solid solution in urea to assist complete dissolution.
Inventors
- 👤 David J. G. Davies
- 👤 Brian J. Meakin
- 👤 John E. Rees
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:22
CPC Classifications
A; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/141; C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0078; C11D3/16; C11D3/20; C11D3/2075; C11D3/2082; C11D3/2086
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
83 words
A solid composition for addition to tap water to provide a non-eye irritant aqueous disinfecting solution for hydrophilic soft contact lenses, said composition comprising: an antimicrobial effective amount of an opthalmically acceptable chlorhexidine salt; an opthalmically acceptable polyphosphate sequestering agent for calcium or magnesium cations in an amount effective to sequester said ions from tap water; and an opthalmically acceptable metabisulphite, sulphite or thiosulphate dechlorinating agent in an amount effective to remove chlorine from a solution of the chlorhexidine salt in tap water.
Claim 2
Dependent Claim
83 words
A solid composition for addition to tap water to provide a non-eye irritant aqueous disinfecting solution for hydrophilic soft contact lenses, said composition comprising: an antimicrobial effective amount of an opthalmically acceptable chlorhexidine salt; an opthalmically acceptable polyphosphate sequestering agent for calcium or magnesium cations in an amount effective to sequester said ions from tap water; and an opthalmically acceptable metabisulphite, sulphite or thiosulphate dechlorinating agent in an amount effective to remove chlorine from a solution of the chlorhexidine salt in tap water.
Claim 3
Dependent Claim
15 words
A composition as claimed in claim 1, which is in the form of a tablet.
Claim 4
Dependent Claim
37 words
A composition as claimed in claim 1, containing 0.0003 to 0.0005 g of chlorhexidine salt (calculated as chlorhexidine digluconate); 0.02 to 0.08 g of the sequestering agent; and 0.0005 g to 0.01 g of the dechlorinating agent.
Claim 5
Dependent Claim
46 words
A composition as claimed in claim 1, wherein the chlorhexidine salt is selected from chlorhexidine diacetate and chlorhexidine digluconate; the sequestering agent is selected from sodium hexametaphosphate, sodium pyrophosphate or sodium tripolyphosphate, and the dechlorinating agent is selected from sodium metabisulphite, sodium sulphite and sodium thiosulphate.
Claim 6
Dependent Claim
37 words
A composition as claimed in claim 1, containing an acid selected from fumaric, citric, maleic, adipic or malic acid in an amount effective to provide the solution with a pH in the range of 4.0 to 8.0.
Claim 7
Dependent Claim
18 words
A composition as claimed in claim 1 containing sodium chloride as a tonicity adjusting agent to provide isotonicity.
Claim 8
Dependent Claim
52 words
A composition as claimed in claim 1 containing an amount sufficient to enhance dissolution of the solid composition on addition to tap water of a system comprising urea and a non-ionic surface active agent selected from polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene sorbitan and other sorbitan and sucrose alkyl esters.
Claim 9
Dependent Claim
13 words
A composition as claimed in claim 7 containing 0.1 to 0.16 g urea.
Claim 10
Dependent Claim
65 words
A tablet for addition to 10 ml tap water to provide a non-eye irritant aqueous disinfecting solution for hydrophilic soft contact lenses, said composition comprising: 0.0003 to 0.0005 g of an opthalmically acceptable chlorhexidine salt, calculated as chlorhexidine digluconate; 0.002 to 0.8 g of a polyphosphate sequestering agent for calcium or magnesium cations; and 0.0005 to 0.01 g of metabisulphite, sulphite or thiosulphate dechlorinating agent.
Claim 11
Dependent Claim
65 words
A tablet for addition to 10 ml tap water to provide a non-eye irritant aqueous disinfecting solution for hydrophilic soft contact lenses, said composition comprising: 0.0003 to 0.0005 g of an opthalmically acceptable chlorhexidine salt, calculated as chlorhexidine digluconate; 0.002 to 0.8 g of a polyphosphate sequestering agent for calcium or magnesium cations; and 0.0005 to 0.01 g of metabisulphite, sulphite or thiosulphate dechlorinating agent.
Claim 12
Dependent Claim
25 words
A tablet for addition to 10 ml tap water to provide a non-eye irritant aqueous disinfecting solution for hydrophilic soft contact lenses, said composition comprising:
Claim 13
Dependent Claim
25 words
A tablet for addition to 10 ml tap water to provide a non-eye irritant aqueous disinfecting solution for hydrophilic soft contact lenses, said composition comprising:
Claim 14
Dependent Claim
88 words
0003 to 0.0005 g of an opthalmically acceptable chlorhexidine salt, calculated as chlorhexidine digluconate, in a solid solution in 0.1 to 0.16 g urea; 0.002 to 0.08 g of a polyphosphate sequestering agent for calcium or magnesium cations; 0.0005 to 0.01 of a metabisulphite, sulphite or thiosulphate dechlorinating agent; and an amount sufficient to enhance dissolution of the tablet on addition to tap water of a non-ionic surface active agent selected from polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene sorbitan and other sorbitan and sucrose alkyl esters.
Claim 15
Dependent Claim
88 words
0003 to 0.0005 g of an opthalmically acceptable chlorhexidine salt, calculated as chlorhexidine digluconate, in a solid solution in 0.1 to 0.16 g urea; 0.002 to 0.08 g of a polyphosphate sequestering agent for calcium or magnesium cations; 0.0005 to 0.01 of a metabisulphite, sulphite or thiosulphate dechlorinating agent; and an amount sufficient to enhance dissolution of the tablet on addition to tap water of a non-ionic surface active agent selected from polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene sorbitan and other sorbitan and sucrose alkyl esters.
Claim 16
Dependent Claim
57 words
A method for disinfecting a hydrophilic soft contact lens which comprises the steps of: (1) dissolving the tablet of claim 2 in a volume of tap water to provide a non-eye irritant aqueous disinfecting solution; and (2) soaking a hydrophilic soft lens in the solution formed in step (1) for a sufficient time to disinfect the lens.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-09 | 1990-08-11 | 1991-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-09 | 1994-08-11 | 1995-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-09 | 1998-08-11 | 1999-02-10 | $7700.00 | Window Closed / Lapsed |