US4639437A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Kit or device and method for administering gangliosides and derivatives thereof by inhalation and pharmaceutical compositions suitable therefor
Assignee: Fidia SpA
•
Filing: 1984-04-12
•
Granted: 1987-01-27
•
Expires: 2004-04-12
Abstract
Abstract The present invention relates to a device or kit and a method for the inhalation administration of gangliosides and inner ester ganglioside derivatives useful for the treatment of various nervous disorders, such as those resulting from accidents or diseases which have damaged the nervous tissue.
Inventors
- 👤 Francesco Della Valle
- 👤 Aurelio Romeo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:57
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/30; A61K9/00; A61K9/0012; A61K9/007; A61K9/0073; A61K9/008; A61K31/00; A61K31/70; A61P; A61P25/00; C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
133 words
A method for stimulating nerve sprouting which comprises administering by inhalation an effective amount of at least one ganglioside compound or a pharmaceutically acceptable salt thereof, or at least one inner ester ganglioside derivative or a pharmaceutically acceptable salt thereof, or mixtures thereof, wherein said inner ester ganglioside derivative comprises: (a) a carbohydrate portion, at least one ceramide and at least one acid moiety; (b) said carbohydrate portion including at least one N-acetylgalactosamine or N-acetylglucosamine moiety and at least one glucose or galactose moiety; (c) said acid moiety including at least one N-acetylneuraminic acid or N-glycolylneuraminic acid; and (d) the carboxyl group of at least one of said acid moieties being ester bonded to a hydroxyl group of one of said carbohydrates or one of said acid moieties to form a lactonic ring.
Claim 2
Independent Claim
133 words
A method for stimulating nerve sprouting which comprises administering by inhalation an effective amount of at least one ganglioside compound or a pharmaceutically acceptable salt thereof, or at least one inner ester ganglioside derivative or a pharmaceutically acceptable salt thereof, or mixtures thereof, wherein said inner ester ganglioside derivative comprises: (a) a carbohydrate portion, at least one ceramide and at least one acid moiety; (b) said carbohydrate portion including at least one N-acetylgalactosamine or N-acetylglucosamine moiety and at least one glucose or galactose moiety; (c) said acid moiety including at least one N-acetylneuraminic acid or N-glycolylneuraminic acid; and (d) the carboxyl group of at least one of said acid moieties being ester bonded to a hydroxyl group of one of said carbohydrates or one of said acid moieties to form a lactonic ring.
Claim 3
Dependent Claim
18 words
The method of claim 1, wherein a single ganglioside compound or a pharmaceutically acceptable salt thereof is administered.
Claim 4
Dependent Claim
18 words
The method of claim 1, wherein a mixture of ganglioside compounds or pharmaceutically acceptable salts thereof is administered.
Claim 5
Dependent Claim
20 words
The method of claim 1, wherein a single inner ester ganglioside derivative or a pharmaceutically acceptable salt thereof is administered.
Claim 6
Dependent Claim
20 words
The method of claim 1, wherein a mixture of inner ester ganglioside derivatives, or pharmaceutically acceptable salts thereof, is administered.
Claim 7
Dependent Claim
36 words
The method of claim 1, wherein a mixture of at least one ganglioside compound or a pharmaceutically acceptable salt thereof and at least one inner ester ganglioside derivative or a pharmaceutically acceptable salt thereof is administered.
Claim 8
Dependent Claim
18 words
The method of claim 1, wherein said compounds are administered in the form of a nebulized aqueous solution.
Claim 9
Dependent Claim
21 words
The method of claim 1, wherein said compounds are administered in the form of a nebulized liquified propellent suspension or solution.
Claim 10
Dependent Claim
17 words
The method of claim 1, wherein said compounds are administered in the form of an atomized powder.
Claim 11
Dependent Claim
44 words
The method of claim 1, wherein in said inner ester ganglioside derivative each of said carboxyl groups of said acid moieties is ester bonded with a hydroxyl group of one of said carbohydrates or with one of said acid moieties to form lactonic rings.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-26 | 1990-07-28 | 1991-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-26 | 1994-07-28 | 1995-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-26 | 1998-07-28 | 1999-01-27 | $7700.00 | Window Closed / Lapsed |