US4639434A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel cyclosporins
Assignee: Novartis AG
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Filing: 1985-03-19
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Granted: 1987-01-27
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Expires: 2005-03-19
Abstract
Abstract Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy- alpha -amino acid residue, typically of formula <IMAGE> wherein X=-MeBmt- or -dihydro-MeBmt-, Y=- alpha Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R1-CO-O-CH(R2)-CH(CO-)-NH-wherein R1=H, C1-4alkyl or phenyl and R2=H or CH3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.
Inventors
- 👤 Roland Wenger
- 👤 Rene P. Traber
- 👤 Hans Kobel
- 👤 Hans Hofmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 06:58
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/64; C07K7/645; A; A61; A61P; A61P29/00; A61P31/00; A61P31/04; A61P33/00; A61P37/00; A61P37/02; A61P37/06; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/19; Y10S930/27
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
95 words
A cyclosporin of formula IIIa, ##STR10## wherein Y' is -αAbu-, -Thr-, -Val- or -Nva-, Z' is -Val-, when Y' is -Thr-, or -Val- or Z' is -Val- or -Nva-, when Y' is -αAbu- or -Nva-, W' is -(D)Ser-, when Y' is -Thr-, -Val- or -Nva- and Z' is -Val-, or when Y' is -αAbu- or -Nva- and Z' is -Nva- or W' is -(D)Thr-, when Y' is -αAbu- and Z is -Val-, and X' is -MeBmt- or X' is -dihydro -MeBmt-, when Y' is -Thr-, -Val-, or -Nva-, Z' is -Val- and W' is -(D)Ser-.
Claim 2
Dependent Claim
95 words
A cyclosporin of formula IIIa, ##STR10## wherein Y' is -αAbu-, -Thr-, -Val- or -Nva-, Z' is -Val-, when Y' is -Thr-, or -Val- or Z' is -Val- or -Nva-, when Y' is -αAbu- or -Nva-, W' is -(D)Ser-, when Y' is -Thr-, -Val- or -Nva- and Z' is -Val-, or when Y' is -αAbu- or -Nva- and Z' is -Nva- or W' is -(D)Thr-, when Y' is -αAbu- and Z is -Val-, and X' is -MeBmt- or X' is -dihydro -MeBmt-, when Y' is -Thr-, -Val-, or -Nva-, Z' is -Val- and W' is -(D)Ser-.
Claim 3
Dependent Claim
11 words
A cyclosporin according to claim 1 which is [(D)Thr] 8 -Cyclosporine.
Claim 4
Dependent Claim
13 words
A cyclosporin according to claim 1 which is [Nva] 2 -[(D)Ser] 8 -Cyclosporine.
Claim 5
Dependent Claim
15 words
A cyclosporin according to claim 1 which is [Nva] 2 -[Nva] 5 [(D)Ser] 8 -Cyclosporine.
Claim 6
Dependent Claim
30 words
A pharmaceutical composition for inducing immuno suppression, treating inflammation, or treating parasitic infection comprising a cyclosporin as defined in claim 1 together with a pharmaceutically acceptable diluent or carrier therefor.
Claim 7
Dependent Claim
40 words
A method of inducing immuno suppression, of treating inflammation or of treating parasitic infection in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a cyclosporin as defined in claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-26 | 1990-07-28 | 1991-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-26 | 1994-07-28 | 1995-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-26 | 1998-07-28 | 1999-01-27 | $7700.00 | Window Closed / Lapsed |