US4639316A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Automatic liquid component separator
Assignee: Becton Dickinson and Co
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Filing: 1984-12-14
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Granted: 1987-01-27
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Expires: 2004-12-14
Abstract
Abstract A device in the form of a sealed transparent tube comprised of glass, for example, is provided for separating the fraction containing cells and cell free fraction of a liquid, such as blood, automatically upon introduction into the device, and without the need for any separate driving force. The device separates whole non-anticoagulated blood, for example, very rapidly upon introduction into the device. The device utilizes a cross-flow filtration area together with a vacuum force applied to the device during manufacture to cause immediate and rapid separation.
Inventors
- 👤 Mourad M. Eldegheidy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 18:09
CPC Classifications
B; B01; B01L; B01L3/00; B01L3/50; B01L3/502; B01D; B01D61/00; B01D61/14; B01D61/18; G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
319 words
A device for the immediate separation of a blood sample into a cell containing and a cell free fraction of said blood sample characterized by (a) an elongated cylindrical tube having a closed end and an open end; (b) said tube defining an evacuated chamber; (c) an elastomeric stopper sealingly closing said open end, said stopper having a bottom surface; (d) a recess in the bottom surface of said stopper facing said evacuated chamber, said recess defining a sample receiving area; (e) a flat elongated separation assembly in said evacuated chamber; (f) said separation assembly positioned in said evacuated chamber to extend from said closed end of said tube to a point spaced from the open end thereof and having a length extending along the central axis of said tube; (g) said separation assembly separating said evacuated chamber into a cell free fraction receiving chamber and a cell containing fraction receiving chamber; (h) said elongated separation assembly comprising (1) a pair of spaced apart elongated walls; (2) said spaced apart walls defining a blood sample collection passage therebetween; (3) the first of said spaced walls containing a cell free fraction receiving distributor panel; (4) the second of said spaced walls containing a sample distribution chamber having first and second ends; (5) said sample distribution chamber connected to said sample receiving area at said first end and to said cell containing fraction receiving chamber at said second end; (6) a membrane separator positioned in said blood sample collection passage and extending along the length thereof; (7) said membrane separator having one side adjacent said cell free fraction receiving distributor panel and one side adjacent said sample distribution chamber; (8) said cell free fraction distributor panel having a plurality of spaced apart channels therein for receiving a cell free fraction passing through said membrane separator; and (9) means providing flow communication between said channels and said cell free fraction receiving chamber.
Claim 2
Independent Claim
319 words
A device for the immediate separation of a blood sample into a cell containing and a cell free fraction of said blood sample characterized by (a) an elongated cylindrical tube having a closed end and an open end; (b) said tube defining an evacuated chamber; (c) an elastomeric stopper sealingly closing said open end, said stopper having a bottom surface; (d) a recess in the bottom surface of said stopper facing said evacuated chamber, said recess defining a sample receiving area; (e) a flat elongated separation assembly in said evacuated chamber; (f) said separation assembly positioned in said evacuated chamber to extend from said closed end of said tube to a point spaced from the open end thereof and having a length extending along the central axis of said tube; (g) said separation assembly separating said evacuated chamber into a cell free fraction receiving chamber and a cell containing fraction receiving chamber; (h) said elongated separation assembly comprising (1) a pair of spaced apart elongated walls; (2) said spaced apart walls defining a blood sample collection passage therebetween; (3) the first of said spaced walls containing a cell free fraction receiving distributor panel; (4) the second of said spaced walls containing a sample distribution chamber having first and second ends; (5) said sample distribution chamber connected to said sample receiving area at said first end and to said cell containing fraction receiving chamber at said second end; (6) a membrane separator positioned in said blood sample collection passage and extending along the length thereof; (7) said membrane separator having one side adjacent said cell free fraction receiving distributor panel and one side adjacent said sample distribution chamber; (8) said cell free fraction distributor panel having a plurality of spaced apart channels therein for receiving a cell free fraction passing through said membrane separator; and (9) means providing flow communication between said channels and said cell free fraction receiving chamber.
Claim 3
Dependent Claim
37 words
The device of claim 1, further characterized by (a) said membrane separator defining individual pores, wherein the diameter of the individual pores of said membrane separator is within the range of between about 0.1 and 2.2 microns.
Claim 4
Dependent Claim
14 words
The device of claim 2, further characterized by (a) said diameter is 0.45 microns.
Claim 5
Dependent Claim
17 words
The device of claim 1, further characterized by (a) a cannula receiving upper well in said stopper.
Claim 6
Dependent Claim
26 words
The device of claim 1, further characterized by (a) said tube is comprised of a member selected from the group consisting of glass, polyethyelene and polypropylene.
Claim 7
Dependent Claim
27 words
The device of claim 1, further characterized by (a) said sample distribution chamber is a recessed distribution channel recessed within the range of 0.01 and 0.03 centimeters.
Claim 8
Dependent Claim
14 words
The device of claim 6, further characterized by (a) said distribution channel is rectangular.
Claim 9
Dependent Claim
20 words
The device of claim 7, further characterized by (a) said distribution channel is 1.5 centimeters wide and 10 centimeters long.
Claim 10
Dependent Claim
20 words
The device of claim 6, further characterized by (a) said distribution channel includes an inlet area with gradually diverging walls.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-26 | 1990-07-28 | 1991-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-26 | 1994-07-28 | 1995-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-26 | 1998-07-28 | 1999-01-27 | $7700.00 | Window Closed / Lapsed |