US4636497A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-thrombotic pharmaceutical compositions comprising tricyclo-4H-1,4-benzothiazine derivatives and method of use therefor
Assignee: Bayer AG
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Filing: 1985-08-29
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Granted: 1987-01-13
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Expires: 2005-08-29
Abstract
Abstract The present invention refers to novel anellated 4H-1,4-benzothiazines, several processes for the synthesis thereof, their use as pharmaceutical agents, in particular their use as lipoxygenase-inhibiting agents, pharmaceutical compositions containing the novel benzothiazines and a process for their manufacture.
Inventors
- 👤 Ekkehard Niemers
- 👤 Rudi Grutzmann
- 👤 Mithat Mardin
- 👤 Wolf-Dieter Busse
- 👤 Horst Meyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 08:36
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04; A; A61; A61P; A61P1/00; A61P1/14; A61P11/00; A61P29/00; A61P35/00; A61P37/00; A61P37/08; C07D279/00; C07D279/10; C07D279/14; C07D279/16; C07D279/18; C07D279/20
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
156 words
A pharmaceutical composition comprising, as an active ingredient an anti-thrombotic-effective amount of a fused 4H-1,4-benzothiazine of the formula ##STR12## wherein R 1 represents hydrogen or C 1 -C 8 -alkyl, R 2 and R 3 represent hydrogen, C 1 -C 8 -alkyl, halogen, nitro, cyano, C 1 -C 8 -alkylsulphonyl, phenylsulfonyl, hydroxyl, C 1 -C 8 -alkoxy or carboxylic acid acyloxy and R 2 and R 3 can be identical or different, with the proviso that R 2 and R 3 do not denote bromine, or R 2 and R 3 do not both denote hydrogen, and X represents alkylene (having 2 to 4 C atoms) which is unsubstituted or substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, phenyl, fluorine or C 1 -C 8 -alkoxycarbonyl, and wherein a methylene group of the alkylene bridge is replaced by O, S, SO 2 , SO, NH or N-alkyl and an inert pharmaceutical carrier.
Claim 2
Dependent Claim
156 words
A pharmaceutical composition comprising, as an active ingredient an anti-thrombotic-effective amount of a fused 4H-1,4-benzothiazine of the formula ##STR12## wherein R 1 represents hydrogen or C 1 -C 8 -alkyl, R 2 and R 3 represent hydrogen, C 1 -C 8 -alkyl, halogen, nitro, cyano, C 1 -C 8 -alkylsulphonyl, phenylsulfonyl, hydroxyl, C 1 -C 8 -alkoxy or carboxylic acid acyloxy and R 2 and R 3 can be identical or different, with the proviso that R 2 and R 3 do not denote bromine, or R 2 and R 3 do not both denote hydrogen, and X represents alkylene (having 2 to 4 C atoms) which is unsubstituted or substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, phenyl, fluorine or C 1 -C 8 -alkoxycarbonyl, and wherein a methylene group of the alkylene bridge is replaced by O, S, SO 2 , SO, NH or N-alkyl and an inert pharmaceutical carrier.
Claim 3
Dependent Claim
42 words
A method for treating thromboses in warm-blooded animals which comprises administering to the said animals an anti-thrombotic effective amount of an active ingredient according to claim 1 either alone or in admixture with a diluent or in the form of a medicament.
References Cited (Backward Citations)
US3422101A
Cited
US4512990A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-12 | 1990-07-14 | 1991-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-12 | 1994-07-14 | 1995-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-12 | 1998-07-14 | 1999-01-13 | $7700.00 | Window Closed / Lapsed |