US4634767A
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Method for preparing spiro(indoline)-type photochromic compounds
Assignee: PPG Industries Ohio Inc
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Filing: 1985-09-03
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Granted: 1987-01-06
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Expires: 2005-09-03
Abstract
Abstract Spiro(indoline)-type photochromic compounds are prepared by admixing a solution of the Fischer's Base reactant in non-polar solvent with a mixture of the pyran- or oxazine-forming reactant, e.g., 5-nitroso-6-hydroxy quinoline, in polar solvent and heating the resulting reaction medium at temperatures sufficient to form the corresponding spiro(indoline)-type compound while simultaneously removing co-product water.
Inventors
- 👤 Charles H. Hoelscher
- 👤 Douglas S. McBain
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 18:24
CPC Classifications
C; C07; C07D; C07D498/00; C07D498/02; C07D498/10; C07D498/12; C07D498/20; G; G03; G03C; G03C1/00; G03C1/685
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
315 words
A process for preparing spiro (indoline)-type compounds represented by the following graphic formula, ##STR6## wherein R 1 is selected from the group consisting of hydrogen, C 1 -C 8 alkyl, phenyl, phen (C 1 -C 4 )alkyl, allyl and mono- and di-substituted phenyl, said phenyl substituents being selected from C 1 -C 4 alkyl and C 1 -C 5 alkoxy; R 2 and R 3 are each selected from the group consisting of hydrogen, C 1 -C 5 alkyl, phenyl, mono- and di-substituted phenyl, benzyl or combine to form a cyclic ring selected from the group consisting of a C 6 -C 8 alicyclic ring, norbornyl and adamentyl, said phenyl substituents being selected from the group consisting of C 1 -C 4 alkyl and C 1 -C 5 alkoxy; R 4 is selected from the group consisting of C 1 -C 5 alkyl, halogen, C 1 -C 5 alkoxy, nitro, cyano, C 1 -C 4 haloalkyl, C 1 -C 4 polyhaloalkyl, and C 1 -C 8 alkoxy carbonyl; R 5 is selected from the group consisting of halogen and C 1 - C 4 alkoxy; X and Y are each selected from the group consisting of carbon and nitrogen; and n is 0, 1 or 2, which comprises mixing: (a) a solution of Fischer's Base in non-polar organic solvent, said reactant being represented by the following graphic formula, ##STR7## wherein R 1 , R 2 , R 3 , R 4 and n are as defined herein, and (b) a slurry of a second reactant in polar organic solvent, said second reactant being represented by the following graphic formula, ##STR8## wherein R 5 , Y, and n are as defined above and Z is nitroso or formyl, in a reaction vessel at tempertures sufficient to cause condensation of the aforesaid reactants, while removing co-product water, said non-polar organic solvent and polar organic solvent being miscible.
Claim 2
Dependent Claim
315 words
A process for preparing spiro (indoline)-type compounds represented by the following graphic formula, ##STR6## wherein R 1 is selected from the group consisting of hydrogen, C 1 -C 8 alkyl, phenyl, phen (C 1 -C 4 )alkyl, allyl and mono- and di-substituted phenyl, said phenyl substituents being selected from C 1 -C 4 alkyl and C 1 -C 5 alkoxy; R 2 and R 3 are each selected from the group consisting of hydrogen, C 1 -C 5 alkyl, phenyl, mono- and di-substituted phenyl, benzyl or combine to form a cyclic ring selected from the group consisting of a C 6 -C 8 alicyclic ring, norbornyl and adamentyl, said phenyl substituents being selected from the group consisting of C 1 -C 4 alkyl and C 1 -C 5 alkoxy; R 4 is selected from the group consisting of C 1 -C 5 alkyl, halogen, C 1 -C 5 alkoxy, nitro, cyano, C 1 -C 4 haloalkyl, C 1 -C 4 polyhaloalkyl, and C 1 -C 8 alkoxy carbonyl; R 5 is selected from the group consisting of halogen and C 1 - C 4 alkoxy; X and Y are each selected from the group consisting of carbon and nitrogen; and n is 0, 1 or 2, which comprises mixing: (a) a solution of Fischer's Base in non-polar organic solvent, said reactant being represented by the following graphic formula, ##STR7## wherein R 1 , R 2 , R 3 , R 4 and n are as defined herein, and (b) a slurry of a second reactant in polar organic solvent, said second reactant being represented by the following graphic formula, ##STR8## wherein R 5 , Y, and n are as defined above and Z is nitroso or formyl, in a reaction vessel at tempertures sufficient to cause condensation of the aforesaid reactants, while removing co-product water, said non-polar organic solvent and polar organic solvent being miscible.
Claim 3
Dependent Claim
19 words
The process of claim 1, wherein co-product water is removed from the reaction vessel, as a water-polar solvent azeotrope.
Claim 4
Dependent Claim
22 words
The process of claim 2, wherein the non-polar solvent has a boiling point greater than the polar solvent and water-polar solvent azeotrope.
Claim 5
Dependent Claim
17 words
The process of claim 1, wherein the non-polar solvent is a C 5 -C 9 liquid hydrocarbon.
Claim 6
Dependent Claim
39 words
The process of claim 2, wherein the polar solvent has a boiling point less than the non-polar solvent, and forms an azeotrope with co-product water, which azeotrope has a boiling point below the boiling point of the non-polar solvent.
Claim 7
Dependent Claim
16 words
The process of claim 1, wherein the polar solvent is a C 1 -C 4 alkanol.
Claim 8
Dependent Claim
12 words
The process of claim 6, wherein the polar solvent is substantially water-free.
Claim 9
Dependent Claim
17 words
The process of claim 1, wherein condensation temperatures are from about 65° C. to about 80° C.
Claim 10
Dependent Claim
26 words
The process of claim 1, wherein the reactants are heated in the reaction vessel in a manner that avoids hot spots on the reaction vessel wall.
Claim 11
Dependent Claim
21 words
The process of claim 1, wherein the volumetric ratio of polar to non-polar solvent in the reaction vessel is about 1:1.
Claim 12
Dependent Claim
36 words
The process of claim 1, wherein the slurry of second reactant is added to the solution of Fischer's Base in the reaction vessel at rate such that the reaction volume remains substantially constant during said addition.
Claim 13
Dependent Claim
21 words
The process of claim 2, wherein co-product water is removed from the reaction vessel as a water-polar solvent-non-polar solvent triple azeotrope.
Claim 14
Dependent Claim
29 words
The process of claim 1, wherein the Fischer's Base reactant is formed in the reaction vessel in situ by reaction of the corresponding indolium salt and a basic reagent.
Claim 15
Dependent Claim
69 words
The process of claim 2, wherein R 1 is hydrogen, C 1 -C 4 alkyl, phenyl or benzyl; R 2 and R 3 are each C 1 -C 5 alkyl; R 4 is C 1 -C 2 alkyl, chlorine, bromine, C 1 -C 5 alkoxy; C 1 -C 4 haloalkyl or C 1 -C 4 polyhaloalkyl; and R 5 is chlorine, bromine, hydrogen or C 1 -C 4 alkoxy.
Claim 16
Dependent Claim
56 words
The process of claim 14, wherein from 10 to 100 volume percent of polar solvent, basis the non-polar solvent, is charged to the reaction vessel containing the Fischer's Base non-polar solvent reactant solution; the resulting mixture is heated to condensation temperatures; and the slurry of second reactant in polar solvent added slowly to the reaction vessel.
Claim 17
Dependent Claim
44 words
The process of claim 14, wherein the non-polar solvent is a C 5 -C 9 liquid hydrocarbon, the polar solvent is a C 1 -C 4 alkanol, the non-polar solvent having a boiling point greater than the polar solvent and the water-polar solvent azeotrope.
Claim 18
Dependent Claim
17 words
The process of claim 16, wherein condensation temperatures are from about 65° C. to about 80° C.
Claim 19
Dependent Claim
44 words
The process of claim 15, wherein the non-polar solvent is a C 5 -C 9 liquid hydrocarbon, the polar solvent is a C 1 -C 4 alkanol, the non-polar solvent having a boiling point greater than the polar solvent and the water-polar solvent azeotrope.
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