US4631294A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of cerebral ischemia with dichloroacetate
Assignee: University of Cincinnati
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Filing: 1985-07-05
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Granted: 1986-12-23
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Expires: 2005-07-05
Abstract
Abstract A method of treating a victim suffering from cerebral ischemia or treating a patient expected to suffer an ischemic insult comprises administering a therapeutically effective amount of a dichloroacetate. The post-treatment occurs within about 48 hours of the ischemic insult and lasts for up to about two days.
Inventors
- 👤 William G. Barsan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:23
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
36 words
A method of alleviating brain damage caused by cerebral ischemia in a mammal comprising parenterally administering thereto a therapeutically effective amount of a composition containing as its active substance a pharmaceutically acceptable salt of dichloroacetic acid.
Claim 2
Independent Claim
36 words
A method of alleviating brain damage caused by cerebral ischemia in a mammal comprising parenterally administering thereto a therapeutically effective amount of a composition containing as its active substance a pharmaceutically acceptable salt of dichloroacetic acid.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein the composition is administered for up to about two days.
Claim 4
Dependent Claim
37 words
The method of claim 1 wherein at least three doses per day of from about 12.5 milligrams per kilogram to about 300 milligrams per kilogram of the dichloroacetate per dose for up to two days is administered.
Claim 5
Dependent Claim
37 words
The method of claim 3 wherein at least three doses per day of from about 25 milligrams per kilogram to about 50 milligrams per kilogram of the dichloroacetate per dose for up to two days is administered.
Claim 6
Dependent Claim
12 words
The method of claim 3 wherein the active substance is sodium dichloroacetate.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein the composition is administered intravenously.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein the dichloroacetate is administered after an ischemic insult.
Claim 9
Dependent Claim
20 words
The method of claim 7 wherein the composition is administered within 48 hours of the occurrence of an ischemic insult.
Claim 10
Dependent Claim
20 words
The method of claim 8 wherein the composition is administered within 12 hours of the occurrence of an ischemic insult.
Claim 11
Dependent Claim
20 words
The method of claim 9 wherein the composition is administered within 60 minutes of the occurrence of an ischemic insult.
Claim 12
Dependent Claim
19 words
The method of claim 1 wherein the dichloroacetate is administered before an event which may lead to ischemic insult.
Claim 13
Dependent Claim
12 words
The method of claim 1 wherein the mammal is a human being.
Claim 14
Dependent Claim
14 words
The method of claim 1 wherein the cerebral ischemia is caused by a stroke.
Claim 15
Dependent Claim
19 words
The method of claim 1 wherein the cerebral ischemia is caused by increased intracranial pressure associated with head trauma.
Claim 16
Dependent Claim
18 words
The method of claim 1 wherein the cerebral ischemia is caused by direct brain damage from head trauma.
Claim 17
Dependent Claim
14 words
The method of claim 1 wherein the cerebral ischemia is caused by cardiac arrest.
Claim 18
Dependent Claim
46 words
The method of claim 1 wherein the pharmaceutically acceptable salt of the dichloroacetic acid is in the form of an alkali metal, alkaline earth metal, ammonium, substituted ammonium where the substituent is a mono- or di-lower alkyl radical of 1-4 carbon atoms or ethylene di-ammonium salt.
Claim 19
Dependent Claim
18 words
The method of claim 17 where the active substance is sodium dichloroacetate, potassium dichloroacetate or diisopropyl ammonium dichloroacetate.
References Cited (Backward Citations)
US3179562A
Cited
US4122188A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-22 | 1990-06-23 | 1990-12-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-22 | 1994-06-23 | 1994-12-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-22 | 1998-06-23 | 1998-12-23 | $7700.00 | Window Closed / Lapsed |