US4629626A
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Hydrothermally treated product of compound having hydrotalcite-like crystal structure composition thereof, and use thereof
Assignee: Kyowa Chemical Industry Co Ltd
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Filing: 1984-06-27
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Granted: 1986-12-16
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Expires: 2004-06-27
Abstract
Abstract A hydrothermally treated product useful for treating an iron deficiency of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe2+,Mg2+)x(Al3+,Fe3+)2(OH)2x+6-nz(An-)z.mH2O (I) wherein An- represents an anion having a valence of n, Mg2+ is within the range of O</=Mg2+<x, Fe3+ is within the range of O</=Fe3+<2, x is a number represented by 1</=x<20, z is a number represented by 0<z<3, and m is a number represented by 0</=m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100 DEG C. to about 200 DEG C. in an aqueous medium.
Inventors
- 👤 Shigeo Miyata
- 👤 Hitoshi Anabuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:46
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/665; C07K14/675; A; A61; A61K; A61K33/00; A61K33/24; A61K33/26; A61P; A61P7/00; C01; C01G; C01G49/00; C01G49/0009; C01G49/0018; C07C; C07C55/00; C07C55/02; C07C55/10; C07C57/00; C07C57/02; C07C57/13; C07C57/15; C07C59/00; C07C59/01; C07C59/08; C07C59/10; C07C59/105; C07C59/235; C07C59/245; C07C59/255; C01P; C01P2002/00; C01P2002/30; C01P2006/00; C01P2006/60
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
108 words
A hydrothermally treated product of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+, Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (I) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of 0≦Mg 2+ <x, Fe 3+ is within the range of 0≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by 0<z<3, and m is a number represented by 0≦m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100° C. to about 200° C. in an aqueous medium.
Claim 2
Dependent Claim
108 words
A hydrothermally treated product of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+, Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (I) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of 0≦Mg 2+ <x, Fe 3+ is within the range of 0≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by 0<z<3, and m is a number represented by 0≦m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100° C. to about 200° C. in an aqueous medium.
Claim 3
Dependent Claim
35 words
The hydrothermally treated product of claim 1 wherein the compound (I) is represented by the following formula (I)' (Fe.sup.2+).sub.x (Al.sup.3+).sub.2 (OH).sub.2x+6-2z (CO.sub.3.sup.2-).sub.z.mH.sub.2 O (I)' wherein x, z and m are as defined in claim 1.
Claim 4
Dependent Claim
17 words
The hydrothermally treated product of claim 1 or 2 wherein x is a number represented by 2.5≦x<8.
Claim 5
Dependent Claim
76 words
The hydrothermally treated product of claim 1 wherein A n- is an anion selected from the group consisting of CO 3 2- , SO 4 2- , OH -1 , (CHOHCOO) 2 2- , (CHOH) 4 CH 2 OHCOO 1- , C 2 H 2 (COO) 2 2- , (CH 2 COO) 2 2- , C 5 H 9 O 5 COO 1- , CH 2 NH 2 COO 1- and CH 3 CHOHCOO 1- .
Claim 6
Dependent Claim
149 words
A composition for increasing at least one of hemoglobin and the serum iron level, said composition comprising (1) an amount, effective for increasing at least one of hemoglobin and the serum iron level, of a hydrothermally treated product of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (I) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of 0≦Mg 2+ <x, Fe 3+ is within the range of 0≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by 0<z<3, and m is a number represented by 0≦m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100° C. to about 200° C. in an aqueous medium, and (2) a pharmaceutically acceptable diluent or carrier.
Claim 7
Dependent Claim
149 words
A composition for increasing at least one of hemoglobin and the serum iron level, said composition comprising (1) an amount, effective for increasing at least one of hemoglobin and the serum iron level, of a hydrothermally treated product of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (I) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of 0≦Mg 2+ <x, Fe 3+ is within the range of 0≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by 0<z<3, and m is a number represented by 0≦m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100° C. to about 200° C. in an aqueous medium, and (2) a pharmaceutically acceptable diluent or carrier.
Claim 8
Dependent Claim
33 words
The composition of claim 5 wherein said compound (I) is represented by the following formula (I)' (Fe.sup.2+).sub.x (Al.sup.3+).sub.2 (OH).sub.2x+6-2z (CO.sub.3.sup.2-).sub.z.mH.sub.2 O (I)' wherein x, z and m are as defined in claim 5.
Claim 9
Dependent Claim
15 words
The composition of claim 5 or 6 wherein x is a number represented by 2.5≦x<8.
Claim 10
Dependent Claim
26 words
The composition of claim 5 wherein the amount of the compound (I) is about 30 to about 95% based on the total weight of the composition.
Claim 11
Independent Claim
141 words
A method for increasing at least one of hemoglobin and the serum iron level, which comprises orally administering an amount, effective for increasing at least one of hemoglobin and the serum iron level, of a hydrothermally treated product of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (I) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of 0≦Mg 2+ <x, Fe 3+ is within the range of 0≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by 0<z<3, and m is a number represented by 0≦m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100° C. to about 200° C. in an aqueous medium.
Claim 12
Independent Claim
141 words
A method for increasing at least one of hemoglobin and the serum iron level, which comprises orally administering an amount, effective for increasing at least one of hemoglobin and the serum iron level, of a hydrothermally treated product of a compound having a hydrotalcite-like crystal structure and represented by the following formula (I) (Fe.sup.2+,Mg.sup.2+).sub.x (Al.sup.3+,Fe.sup.3+).sub.2 (OH).sub.2x+6-nz (A.sup.n-).sub.z.mH.sub.2 O (I) wherein A n- represents an anion having a valence of n, Mg 2+ is within the range of 0≦Mg 2+ <x, Fe 3+ is within the range of 0≦Fe 3+ <2, x is a number represented by 1≦x<20, z is a number represented by 0<z<3, and m is a number represented by 0≦m<20, the product being formed by the thermal treatment of the compound of formula (I) at a temperature of about 100° C. to about 200° C. in an aqueous medium.
Claim 13
Dependent Claim
33 words
The method of claim 9 wherein the compound (I) is represented by the following formula (I)' (Fe.sup.2+).sub.x (Al.sup.3+).sub.2 (OH).sub.2x+6-2z (CO.sub.3.sup.2-).sub.z.mH.sub.2 O (I)' wherein x, z and m are as defined in claim 9.
Claim 14
Dependent Claim
27 words
The method of claim 9 or 10 wherein the dosage of the hydrothermally treated product is about 50 mg to about 2,000 mg per day per adult.
Claim 15
Dependent Claim
15 words
The method of claim 9 or 10 for treating a patient suffering from anemic symptoms.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-15 | 1990-06-16 | 1990-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-15 | 1994-06-16 | 1994-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-15 | 1998-06-16 | 1998-12-16 | $7700.00 | Window Closed / Lapsed |